MicroRNA 135 Regulates HOXA10 Expression in Endometriosis

Petracco, Rafaella; Grechukhina, Olga; Popkhadze, Shota; Massasa, Efi E.; Zhou, Yamei; Taylor, Hugh S.

doi:10.1210/jc.2011-1231

Cited by 117 publications

(97 citation statements)

References 29 publications

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“…For example, down-regulation of miR-9* has been demonstrated in the endometria (33) as well as serum samples (16) of women with endometriosis, but most of the reported endometriosisassociated dysregulated endometrial miRNAs have not been shown to be altered in plasma. Interestingly, miR-135a that was overexpressed in the endometrium of endometriosis patients (35) showed significantly lower levels in sera of patients with endometriosis compared with control subjects (18). We previously demonstrated that miR-200a, miR-200b, and miR-141 are not differentially expressed in the endometrium of women with and without endometriosis (22), so endometrium is likely not the tissue of origin for the miR-200 plasma alterations in endometriosis.…”

Section: Discussionmentioning

confidence: 94%

Circulating miR-200–family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time

Rekker

Saare

Roost

et al. 2015

Fertility and Sterility

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Section: Discussionmentioning

confidence: 94%

Circulating miR-200–family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time

Rekker

Saare

Roost

et al. 2015

Fertility and Sterility

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“…Evidence suggested that the expression of VEGFA was highly regulated in a temporal and spatial manner at the early stage of implantation [46]. HOXA10, a homeobox-containing transcription factor, expressed cyclically during the menstrual cycle in the endometrium under the influence of steroid hormone, and had the highest expression level during WOI [47,48]. OPN played an important role in endometrial receptivity due to its consistent up-regulation during the WOI [49].…”

Section: Mir-181a Might Participate In the Formation Of Endometrial Rmentioning

confidence: 99%

WITHDRAWN: Endometrial epithelial cell apoptosis is inhibited via a ciR8073-miR181a-neurotensis pathway during embryo implantation

Zhang¹,

Liu²,

Liu³

et al. 2018

Oncotarget

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Development of receptive endometrium (RE) from pre-receptive endometrium (PE) is essential for embryo implantation, but the molecular mechanisms are not fully understood. In this study, lncRNA/circRNA-miRNA-mRNA networks were constructed to explore the functions of potential competing endogenous RNAs (ceRNA) during the development of RE in dairy goats. We observed that circRNA8073 (ciR8073) decreased levels of miR-181a by acting as a miRNA sponge. This effect indirectly increased expression of neurotensin in endometrial epithelial cells (EECs). Neurotensin in turn inhibited EEC apoptosis by increasing expression of BCL-2/BAX via the MAPK pathway, and also increased expression leukemia-inhibitory factor, cyclo-oxygenase 2, vascular endothelial growth factor A and homeobox A10. We have thus identified a ciR8073-miR181a-neurotensin pathway in the endometrium of dairy goats. Via this pathway, ciR8073 functions as a ceRNA that sequesters miR-181a, thereby protecting neurotensin transcripts from miR-181a-mediated suppression in EECs.

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“…We confirmed with miR-specific quantitative PCR that miR-30b, -30d, -31, and -203 were significantly overexpressed and miR-503 and -145 were significantly under-expressed in endometrial tissue obtained in the mid-secretory phase as compared to the proliferative phase (Table2). Since miR135a and -135b have been implicated as important regulators of HOX genes during implantation [35,36], we also examined their expression but found no difference between CD 7-10 and 20-24 (Table 2).…”

Section: Differential Endometrial Mirna Expression In the Window Of Imentioning

confidence: 99%

MicroRNA-31 is Significantly Elevated in Both Human Endometrium and Serum During the Window of Implantation: A Potential Biomarker for Optimum Receptivity1

Kresowik

Devor

Voorhis

et al. 2014

Biology of Reproduction

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The window of implantation of human embryos into the endometrium spans Cycle Days 20-24 of the 28-day menstrual cycle. However, uterine receptivity may not be reliably replicated in infertile patients throughout this span. Thus, it is of importance to be able to determine optimal receptivity through a minimally invasive measure. We screened expression of a number of candidate micro-RNAs (miRNAs) in endometrial tissues and serum collected from a panel of fertile women during both the proliferative phase and the secretory phase of a normal menstrual cycle. We found that several miRNAs were significantly elevated in endometrial tissues in the secretory phase versus the proliferative phase. One of these, miR-31, was found to be not only detectable in serum samples but also significantly elevated in the secretory phase versus the proliferative phase. MiR-31 is known to target several immunomodulatory factors, such as FOXP3 and CXCL12. We find that both of these factors are significantly downregulated in endometrial tissues during the secretory phase. Our data suggest that miR-31 is a potential biomarker for optimal endometrial receptivity, possibly operating through an immunosuppressive mechanism.

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MicroRNA 135 Regulates HOXA10 Expression in Endometriosis

Abstract: HOXA10 was aberrantly regulated in the endometrium of women with endometriosis by both miR135a and miR135b. Increased microRNA expression likely suppresses genes required for implantation.

Cited by 117 publications

References 29 publications

Circulating miR-200–family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time

Circulating miR-200–family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time

WITHDRAWN: Endometrial epithelial cell apoptosis is inhibited via a ciR8073-miR181a-neurotensis pathway during embryo implantation

MicroRNA-31 is Significantly Elevated in Both Human Endometrium and Serum During the Window of Implantation: A Potential Biomarker for Optimum Receptivity1

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