MicroRNA‐140 inhibit prostate cancer cell invasion and migration by targeting YES proto‐oncogene 1

Zhao, Shijia; Jie, Chuanling; Xu, Pengchao; Diao, Yong

doi:10.1002/jcb.29231

Cited by 9 publications

(8 citation statements)

References 30 publications

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“…In harmony with an oncogenic role of YES1, several microRNAs have been shown to inhibit the proliferation of tumor cells by targeting YES1 (Tan, Lim and Tan, 2015, Shen et al, 2019, Zhao et al, 2020.…”

Section: Several Lines Of Evidence Have Established An Oncogenic Rolementioning

confidence: 99%

Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

Bányai

Trexler

Kerekes

et al. 2021

eLife

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A major goal of cancer genomics is to identify all genes that play critical roles in carcinogenesis. Most approaches focused on genes positively selected for mutations that drive carcinogenesis and neglected the role of negative selection. Some studies have actually concluded that negative selection has no role in cancer evolution. We have re-examined the role of negative selection in tumor evolution through the analysis of the patterns of somatic mutations affecting the coding sequences of human genes. Our analyses have confirmed that tumor suppressor genes are positively selected for inactivating mutations, oncogenes, however, were found to display signals of both negative selection for inactivating mutations and positive selection for activating mutations. Significantly, we have identified numerous human genes that show signs of strong negative selection during tumor evolution, suggesting that their functional integrity is essential for the growth and survival of tumor cells.

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Section: Several Lines Of Evidence Have Established An Oncogenic Rolementioning

confidence: 99%

Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

Bányai

Trexler

Kerekes

et al. 2021

eLife

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“…Zhao et al. reported that miR-140 inhibited PC cells invasion and migration by targeting YES proto-oncogene 1, indicating that miR-140 could be a potential target for PC therapy ( 62 ).…”

Section: Resultsmentioning

confidence: 99%

“…In most cases, miRNAs are regarded to be negative regulators of gene expression ( 72 ). Previous studies indicated that miR-140 functions as a tumor suppressor by targeting several kinds of genes, including FEN1 ( 60 ), YES1 ( 62 ) and BIRC6 ( 73 ). Downregulation of miR-140 is implicated in the development of PC by regulating cancer stem cell formation, tumor invasion, and angiogenesis ( 73 , 74 ).…”

Section: Discussionmentioning

confidence: 99%

“…MiR-140 aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2 (61). Zhao et al reported that miR-140 inhibited PC cells invasion and migration by targeting YES proto-oncogene 1, indicating that miR-140 could be a potential target for PC therapy (62).…”

Section: Mir-140 Targets and Represses Ogt Expressionmentioning

confidence: 99%

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Inhibition of O-GlcNAc transferase sensitizes prostate cancer cells to docetaxel

Xia¹,

Wang²,

Qi³

et al. 2022

Front. Oncol.

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The expression of O-GlcNAc transferase (OGT) and its catalytic product, O-GlcNAcylation (O-GlcNAc), are elevated in many types of cancers, including prostate cancer (PC). Inhibition of OGT serves as a potential strategy for PC treatment alone or combinational therapy. PC is the second common cancer type in male worldwide, for which chemotherapy is still the first-line treatment. However, the function of inhibition of OGT on chemotherapeutic response in PC cells is still unknown. In this study, we show that inhibition of OGT by genetic knockdown using shRNA or by chemical inhibition using OGT inhibitors sensitize PC cells to docetaxel, which is the most common chemotherapeutic agent in PC chemotherapy. Furthermore, we identified that microRNA-140 (miR-140) directly binds to OGT mRNA 3′ untranslated region and inhibits OGT expression. Moreover, docetaxel treatment stimulates miR-140 expression, whereas represses OGT expression in PC cells. Overexpression of miR-140 enhanced the drug sensitivity of PC cells to docetaxel, which could be reversed by overexpression of OGT. Overall, this study demonstrates miR-140/OGT axis as therapeutic target in PC treatment and provides a promising adjuvant therapeutic strategy for PC therapy.

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“…24 MiR-140 overexpression impeded migration and invasion of prostate cancer cell. 25 Moreover, miR-140-5p also has been revealed as a suppressor in gastric cancer, hepatocellular carcinoma, breast cancer, and so forth. [26][27][28] Our study proved that miR-140 overexpression impeded the development of esophageal cancer in vitro and in vivo, which is consistent with previous studies.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-140 Represses Esophageal Cancer Progression via Targeting ZEB2 to Regulate Wnt/β-Catenin Pathway

Yang

Shen

et al. 2021

Journal of Surgical Research

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MicroRNA‐140 inhibit prostate cancer cell invasion and migration by targeting YES proto‐oncogene 1

Cited by 9 publications

References 30 publications

Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

Inhibition of O-GlcNAc transferase sensitizes prostate cancer cells to docetaxel

MicroRNA-140 Represses Esophageal Cancer Progression via Targeting ZEB2 to Regulate Wnt/β-Catenin Pathway

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