2019
DOI: 10.3892/mmr.2019.10475
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MicroRNA‑140 suppresses Helicobacter pylori‑positive gastric cancer growth by enhancing the antitumor immune response

Abstract: immune checkpoint blockade is a promising therapeutic strategy against various human malignancies. Micrornas (mirnas/mirs) regulate gene expression, by repressing mrna translation or promoting its degradation. The aim of the current study was to investigate the role and molecular mechanisms of mir-140 in Helicobacter pylori (Hp)-associated gastric cancer, and to examine its relationship with immune function in gastric cancer. Gastritis tissue samples from gastritis patients, and gastric cancer tissue samples f… Show more

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Cited by 11 publications
(12 citation statements)
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“…In addition, the miR-140 overexpression-induced alterations were down-regulated by PD-L1 plasmid. These findings verified that miR140 exerts an anti-GC effect by targeting PD-L1 (48).…”
Section: Suppress-mirnassupporting
confidence: 75%
“…In addition, the miR-140 overexpression-induced alterations were down-regulated by PD-L1 plasmid. These findings verified that miR140 exerts an anti-GC effect by targeting PD-L1 (48).…”
Section: Suppress-mirnassupporting
confidence: 75%
“…MiR-140 played a suppressive role in the growth of gastric cancer in vitro and in vivo ( 54 , 55 ). It also strengthened antitumor immunity in gastric cancer ( 20 ). PD-L1 was directly targeted by miR-140 in gastric cancer cells ( 20 ).…”
Section: The Impact Of Ncrnas Targeting Pd-1/pd-l1 On Cancermentioning
confidence: 99%
“…These findings suggest that miR-140 has an anti-GC effect by targeting the immunoassay molecule PD-L1. Therefore, miR-140 may be a promising and new immunotherapy target for GC treatment [ 146 ].…”
Section: Therapymentioning
confidence: 99%