MicroRNA-145: a promising biomarker for hepatocellular carcinoma (HCC)

Duan, Xianchun; Hu, Jianpeng; Wang, Yongzhong; Gao, Jiarong; Peng, Daiyin; Lun-zhu, Xia

doi:10.1016/j.gene.2014.03.018

Cited by 24 publications

(20 citation statements)

References 8 publications

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“…Aberrant expression of some miRNAs could be used as a prognostic indicator for HCC [8,15,16]. MiR-24 has been found to serve as an oncogene in several cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Aberrant miRNA expression has been found to be associated with the carcinogenesis of a variety of cancers, including HCC [6,7]. Furthermore, miRNAs can act as oncogene or tumor suppressor and could be used as biomarkers for both diagnosis and prognosis prediction of cancers [8,9]. However, deregulated miRNAs and their detailed molecular roles in tumorigenesis are still not well understood.…”

Section: Introductionmentioning

confidence: 99%

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miR-24 promotes the proliferation and invasion of HCC cells by targeting SOX7

She

Ming

et al. 2014

Tumor Biol.

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Accumulating evidence shows that microRNAs (miRNAs) are involved in the development and progression of multiple tumors, including hepatocellular carcinoma (HCC). Recent studies have found that miR-24 acts as an oncogene in several tumors; however, the function of miR-24 in HCC remains unclear. In this study, we found that miR-24 was increased in HCC tissues and cell lines. Inhibition of miR-24 by inhibitor significantly suppressed HCC cells proliferation, migration, and invasion. Furthermore, the sex-determining region Y (SRY)-box 7 (SOX7), a putative tumor suppressor, was found to be a target of miR-24 in HCC cells. Forced expression of SOX7 substantially attenuated the oncogenic effects of miR-24. Those results strongly suggest that miR-24 plays important role in HCC development partially by targeting SOX7.

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“…Aberrant expression of some miRNAs could be used as a prognostic indicator for HCC [8,15,16]. MiR-24 has been found to serve as an oncogene in several cancers.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

miR-24 promotes the proliferation and invasion of HCC cells by targeting SOX7

She

Ming

et al. 2014

Tumor Biol.

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“…In addition, the OS rate of the high miR-221 expression group was significantly lower than that of the low miR-221 expression group [70]. Increasing numbers of miRNAs could be significant biomarkers for the management of HCC (Table 4) [71][72][73][74].…”

Section: Novel Cytokine and Protein Biomarkersmentioning

confidence: 99%

Significant biomarkers for the management of hepatocellular carcinoma

Kondo

Kimura

Shimosegawa

2015

Clin J Gastroenterol

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Surveillance of hepatocellular carcinoma (HCC) is important for early detection. Imaging tests including computed tomography, magnetic resonance imaging and ultrasonography with or without various kinds of contrast medium are important options for detecting HCC. In addition to the imaging tests, various kinds of biomarkers including alpha-fetoprotein (AFP), lectin-bound AFP (AFP-L3) and protein induced by vitamin K absence or antagonist II (PIVKA-II) have been widely used to detect HCC and analyze treatment response. Recently, various kinds of novel biomarkers (proteins and miRNA) have been found to predict the malignancy potential of HCC and treatment response to specific therapies. Moreover, various combinations of well-established biomarkers and novel biomarkers have been tested to improve sensitivity and specificity. In practical terms, biomarkers that can be analyzed using peripheral blood samples might be more useful than immunohistochemical techniques. It has been reported that quantification of cytokines in peripheral blood and the analysis of peripheral immune subsets could be good biomarkers for managing HCC. Here, we describe the usefulness of and update well-established and novel biomarkers for the management of HCC.

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“…A piece of increasing evidence likely supports this possibility. Indeed, several miRNAs among those of C mi have been reported as being deregulated in HCC tissues from different etiologies including patients with hepatitis C (13-16) and/or have been suggested as potential biomarkers for HCC (17)(18)(19). In this picture C mi holds potential as a universal miRNA classifier for HCC.…”

mentioning

confidence: 99%