MicroRNA-146a inhibits autophagy to maintain the intracellular survival of Burkholderia pseudomallei by targeting LIPA

Hu, Zhiqiang; Li, Qian; Hu, Zhenhong; Liu, Haichao; Rao, C. S.; Zhang, Meijuan; Xia, Yupei; Deng, Ling; Mao, Xuhu; Yao, Fang

doi:10.1016/j.micpath.2021.104969

Cited by 1 publication

(1 citation statement)

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“…In the present study, the expression of lysosomal acid lipase ( lipa ) and Niemannc1 protein ( npc ) genes involved in the transport and catabolism pathway were significantly changed at medium and high concentrations. Lipa is an important regulatory factor of lysosomal lipolysis; meanwhile, the hydrolysis of cholesterol esters and triglycerides in lysosomes under acidic conditions is closely related to the production of lipid mediators, macrophage M2 activation, and inflammation [ 53 ]. As it was proven that the dysfunction of the lysosome is connected with the abnormal expression of lysosomal autophagy genes, the lysosomal somatic autophagy could be effectively blocked by down-regulated lipa [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis of Diethylstilbestrol in Daphnia Magna: Energy Metabolism and Growth Inhibition

Zhao

Guo

et al. 2023

Toxics

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With the widespread use of diethylstilbestrol (DES), it has become a common contaminant in the aquatic environment. It is toxic to a wide range of aquatic organisms, disrupting the water flea growth and further interfering with several ecosystem services. Nevertheless, the molecular mechanism of DES in water fleas is still unexplicit. In this study, the 21-day chronic test showed that a negative effect of growth and reproduction can be observed with DES exposure. Subsequently applied transcriptomic analysis illustrated the molecular mechanism in mode freshwater invertebrate Daphnia magna (D. magna) exposed to 2, 200, and 1000 μg·L−1 of DES for 9 days. Meanwhile, exposure to DES at 200 and 1000 μg·L−1 significantly restrains the growth (body length) and reproduction (first spawning time) of D. magna. Identified differentially expressed genes (DEGs) are majorly enriched relative to energy metabolism, lipid metabolism, the digestive system, transport and catabolism pathways which were remarkably changed. These repressed and up-regulated pathways, in relation to energy synthesis and metabolism, may be the reasons for the reduced body length and delayed first spawning time. Taken together, this study revealed that DES is a threat to D. magna in the aquatic environment and clarifies the molecular mechanism of the toxicity.

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Section: Discussionmentioning

confidence: 99%