MicroRNA-149 Suppresses Colorectal Cancer Cell Migration and Invasion by Directly Targeting Forkhead Box Transcription Factor FOXM1

Xu, Kai; Liu, Fei; Mao, Xiaobei; Xue, Lijun; Wang, Rui; Chen, Longbang; Chen, Xiaoyuan

doi:10.1159/000369715

Cited by 83 publications

(77 citation statements)

References 35 publications

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“…miRNA is thereby a potential diagnostic and prognostic marker of TSCC with therapeutic potential (18)(19)(20). Previous studies revealed that miR-149 was downregulated in colorectal cancer, breast cancer, gastric cancer, glioma, melanoma and non-small cell lung cancer (21)(22)(23)(24)(25)(26). This study investigated the expression, biological functions and molecular mechanisms of miR-149 in TSCC.…”

Section: Discussionmentioning

confidence: 96%

MicroRNA-149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility

Chen

2016

Oncology Letters

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Section: Discussionmentioning

confidence: 96%

MicroRNA-149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility

Chen

2016

Oncology Letters

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“…MiRNAs can function as an oncogene, and the targeting of tumour suppressor genes by these oncogenic miRNAs provides favourable conditions for tumour growth, metastasis and infiltration [24, 25]. On the other hand, miRNAs can also have tumour-suppressive function, and the targeting of oncogenes by these miRNAs can contribute to tumour apoptosis, differentiation and treatment [26-28]. As a consequence of the important functions mediated by miRNAs in cancer cells, potential therapeutic approaches that target this pathway have recently attracted attention [29-31].…”

Section: Discussionmentioning

confidence: 99%

A Novel Role for MiR-520a-3p in Regulating EGFR Expression in Colorectal Cancer

Zhang

Liu

et al. 2017

Cell Physiol Biochem

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Background/Aims: MicroRNAs (miRNAs) have been consistently demonstrated to be involved in colorectal cancer as either tumour oncogenes or tumour suppressors. However, the detailed role of miR-520a-3p in colorectal cancer remains poorly understood. Methods: Quantitative RT-PCR and western blotting assays were used to measure miR-520a-3p and EGFR expression levels in colorectal cancer tissues, respectively. Luciferase reporter assay was employed to validate the direct targeting of EGFR by miR-520a-3p. Cell migration, apoptosis and cell cycle assays were performed to analyse the biological functions of miR-520a-3p and EGFR in colorectal cancer cells. In vivo experiment was performed to analyse the effects of miR-520a-3p and EGFR on the growth of colorectal cancer xenografts in mice. Results: In this study, we found that miR-520a-3p was most likely to target the EGFR 3’-UTR, which was experimentally validated. In addition, we investigated the biological effects of EGFR inhibition by miR-520a-3p both in vitro and In vivo and found that miR-520a-3p could suppress cell migration, promote apoptosis, lead to colorectal cancer cell cycle arrest at the G0/G1 phase, and decelerate tumour growth in xenograft mice, potentially by targeting EGFR. Conclusions: This study highlights a tumour suppressor role for miR-520a-3p in colorectal cancer via the regulation of EGFR expression. Thus, miR-520a-3p may be a novel molecular therapeutic target for colorectal cancer.

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“…Although traditional surgical resection TME (total mesorectal excision) and CME (complete mesocolic excision) achieve excellent oncological control and long-term survival for colorectal cancer patients, these approaches are also associated with substantial morbidity and mortality [11,12]. …”

Section: Discussionmentioning

confidence: 99%

Predictors of Lymph Node Metastasis and Prognosis in pT1 Colorectal Cancer Patients with Signet-Ring Cell and Mucinous Adenocarcinomas

Song

Xiao

2017

Cell Physiol Biochem

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Background/Aims: The local excision of early colorectal cancer is limited by the presence of lymph node metastasis (LNM). Signet-ring cell carcinomas (SRC) and mucinous adenocarcinomas (MAC) are two relatively infrequent histological subtypes. However, little is known about the predictors of LNM and prognosis to support the feasibility of local excision in early-stage SRC and MAC. Methods: The Surveillance Epidemiology and End Results Database were used to identify all patients with pT1 adenocarcinomas, including conventional adenocarcinoma (AC), MAC, and SRC. The prevalence of LNM was assessed, and the long-term survival rate in the above three types of colorectal cancer was calculated. Results: SRC accounted for 0.3% and MAC accounted for 4.4% of the entire cohort of colorectal adenocarcinomas. Compared to AC, MRC and SRC were more often located in the proximal colon, and exhibited a higher grade. The incidence of LNM in AC, MAC, and SRC was 10.6%, 17.2%, and 33.3% for colon cancers and 14.8%, 25.9%, and 46.2% for rectal cancers, respectively. In patients with lymph nodes resected no less than 12, incidence of LNM in AC, MRC, and SRC was 12%, 21%, and 44% for colon tumors and 17%, 30%, and 14% for rectal tumors, respectively. Although, colon patients MAC showed an entirely worse survival rate than AC, rectum patients MAC showed a similar prognosis to AC. We found that in patients with rectal tumors, SRC had a worse 3 and 5-year prognosis than AC. However, for colon cancers, the prognosis of SRC was similar to that of AC. Histology was not found to be an independent prognostic factor in multivariate survival analysis. Conclusions: MAC and SRC are two distinct subtypes of colorectal cancer that require special attention despite their relatively rare prevalence. pT1 patients with SRC of the rectum and patients with MAC of the colon have higher incidences of LNM, and with these adverse outcomes, local excision is not recommended. AlthoughMAC of the rectum and SRC of colon have a high rate of LNM, the prognosis of these types are similar to that of AC.

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MicroRNA-149 Suppresses Colorectal Cancer Cell Migration and Invasion by Directly Targeting Forkhead Box Transcription Factor FOXM1

Cited by 83 publications

References 35 publications

MicroRNA-149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility

MicroRNA-149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility

A Novel Role for MiR-520a-3p in Regulating EGFR Expression in Colorectal Cancer

Predictors of Lymph Node Metastasis and Prognosis in pT1 Colorectal Cancer Patients with Signet-Ring Cell and Mucinous Adenocarcinomas

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