MicroRNA-150 as a Potential Biomarker in Diagnosis of Cancer: a Meta-Analysis

Yan, Jin; Li, Xuan; Peng, Lei; Shen, Xiaoran; Dang, Yini; Zhang, Guoxin

doi:10.7754/clin.lab.2017.170522

Cited by 5 publications

(6 citation statements)

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“…PubMed, Embase, and Web of Science for publications were searched using the keywords of miR-150 and human cancer. (J. Yan et al 2017 , p. 1187)…”

Section: Resultsmentioning

confidence: 99%

“…(Wang et al 2017 , p. 59666) PubMed, Embase, and Web of Science for publications were searched using the keywords of miR-150 and human cancer. (J. Yan et al 2017 , p. 1187) We searched in EBSCO, PsycINFO, Google Scholar, Web of Science , and NCBI databases and other articles manually from lists of references of extracted articles. (Piqueras, Martín-Vivar, Sandin, San Luis, & Pineda 2017 , p. 153) The same pattern was found for the four other top verbs listed in Table 7 .…”

Section: Resultsmentioning

confidence: 99%

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Web of Science use in published research and review papers 1997–2017: a selective, dynamic, cross-domain, content-based analysis

2017

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Clarivate Analytics’s Web of Science (WoS) is the world’s leading scientific citation search and analytical information platform. It is used as both a research tool supporting a broad array of scientific tasks across diverse knowledge domains as well as a dataset for large-scale data-intensive studies. WoS has been used in thousands of published academic studies over the past 20 years. It is also the most enduring commercial legacy of Eugene Garfield. Despite the central position WoS holds in contemporary research, the quantitative impact of WoS has not been previously examined by rigorous scientific studies. To better understand how this key piece of Eugene Garfield’s heritage has contributed to science, we investigated the ways in which WoS (and associated products and features) is mentioned in a sample of 19,478 English-language research and review papers published between 1997 and 2017, as indexed in WoS databases. We offered descriptive analyses of the distribution of the papers across countries, institutions and knowledge domains. We also used natural language processingtechniques to identify the verbs and nouns in the abstracts of these papers that are grammatically connected to WoS-related phrases. This is the first study to empirically investigate the documentation of the use of the WoS platform in published academic papers in both scientometric and linguistic terms.

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“…PubMed, Embase, and Web of Science for publications were searched using the keywords of miR-150 and human cancer. (J. Yan et al 2017 , p. 1187)…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Web of Science use in published research and review papers 1997–2017: a selective, dynamic, cross-domain, content-based analysis

2017

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“…Receiver operating characteristic curve (ROC) analysis confirmed that plasma miR-145 is a candidate biomarker for detecting cervical cancer and differentiating complete responders from incomplete responders ( Wei et al, 2017 ). Yan et al (2017) carried out a meta-analysis that included 7 original studies (data from PubMed, Embase, and Web of Science), and discovered that miR-150 may be a potential non-invasive tumor marker for various human cancers (leukemia, colorectal, hepatocellular, and lung cancer) ( Yan et al, 2017 ). Besides, a total of 73 patients with papillary thyroid carcinoma were enrolled.…”

Section: Theranostic Value Of Mir In Rectal Cancermentioning

confidence: 99%

MicroRNA: Another Pharmacological Avenue for Colorectal Cancer?

Yan

Wang

et al. 2020

Front. Cell Dev. Biol.

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MicroRNAs (miR) are single-stranded RNA of 21-23 nucleotides in length that repress mRNA translation and induces mRNA degradation. miR acts as an endogenous factor of gene expression and plays a crucial part in cancer biology such as cell development, proliferation, differentiation, and apoptosis. Numerous research has indicated that dysregulation of miR associates with colorectal carcinogenesis. In this review article, we firstly introduce the background of miR and colorectal cancer, and the mechanisms of miR in colorectal cancer, such as the proliferation, apoptosis, and progression. Then, we summarize the theranostic value of miR in colorectal cancer. Eventually, we discuss the potential directions and perspectives of miR. This article serves as a guide for further studies and implicate miR as a potent theranostic target for colorectal cancer.

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“…The abnormal expression of miRNA is associated with a variety of diseases including tumors (7). miRNA has been demonstrated to be involved in the regulation of tumor cell proliferation, apoptosis, differentiation, drug resistance, invasion and metastasis, among which miR-150 also ion, drug resistance, invasion and metastasis, among which miR-150 also serves an important role in the development of tumors (10)(11)(12)(13)(14)(15). In colorectal cancer, breast cancer and melanoma, miR-150 is significantly downregulated and exerts a tumor suppressive role (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

“…However, in cervical cancer, miR-150 is highly expressed and promotes tumor progression (14). Therefore, miR-150 serves different roles in different tumor types (10)(11)(12)(13)(14). miR-150-5p, a member of the miR-150 family, has been determined to inhibit cancer cell aggressiveness by targeting cwcv and kazal like domains proteoglycan 1 in head and neck squamous cell carcinoma (15).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑150‑5p and SRC kinase signaling inhibitor 1 involvement in the pathological development of gastric cancer

Quan

Chen

et al. 2019

Exp Ther Med

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The current study aimed to assess the regulatory mechanism of microRNA-150-5p (miR-150-5p) in the pathogenesis of gastric cancer. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was performed to verify the expression of miR-150-5p in gastric cancer tissues and cell lines, which was revealed to be highly expressed in each. In addition, the expression of miR-150-5p was associated with advanced gastric cancer and lymph node metastasis. The current study then hypothesized that SRC kinase signaling inhibitor 1 (SRCIN1) was the target gene of miR-150-5p, a theory that was confirmed via a dual luciferase reporter gene assay. RT-qPCR and western blotting were then performed to verify the expression of SRCIN1 in gastric cancer tissues and cell lines. The results demonstrated that SRCIN1 was lowly expressed in gastric cancer tissues and cells. To assess the effect of miR-150-5p on gastric cancer cells, experiments were conducted with BGC-823 cells transfected with a miR-150-5p inhibitor or a miR-150-5p inhibitor+SRCIN1-small interfering (si)RNA respectively. A cell counting kit-8 assay and flow cytometry were also used to assess cell viability and apoptosis, respectively. Western blotting and RT-qPCR were further used to measure the expression of specific markers of epithelial mesenchymal transition (EMT), including epithelial cell markers (E-cadherin and zona occluding-1) and interstitial cell markers (vimentin, N-cadherin and β-catenin). The results revealed that the miR-150-5p inhibitor attenuated cell viability, induced apoptosis, decreased the expression of interstitial cell markers and increased epithelial cell marker expression. However, all effects of the miR-150-5p inhibitor were reversed following SRCIN1-siRNA treatment. In summary, the current study indicated that the miR-150-5p inhibitor attenuated cell viability, induced apoptosis and inhibited gastric cancer cell EMT by targeting SRCIN1.

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MicroRNA-150 as a Potential Biomarker in Diagnosis of Cancer: a Meta-Analysis

Abstract: miR-150 may be a potential noninvasive tumor marker for various human cancers and further studies with a large sample size are needed to confirm.

Cited by 5 publications

References 0 publications

Web of Science use in published research and review papers 1997–2017: a selective, dynamic, cross-domain, content-based analysis

Web of Science use in published research and review papers 1997–2017: a selective, dynamic, cross-domain, content-based analysis

MicroRNA: Another Pharmacological Avenue for Colorectal Cancer?

MicroRNA‑150‑5p and SRC kinase signaling inhibitor 1 involvement in the pathological development of gastric cancer

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