MicroRNA-150 Modulates Ischemia-Induced Neovascularization in Atherosclerotic Conditions

Abstract

Hypercholesterolemia is associated with reduced expression of miR-150, impaired Src signaling, and inefficient neovascularization in response to ischemia. Forced expression of miR-150 using a miR mimic could constitute a novel therapeutic strategy to improve ischemia-induced neovascularization in atherosclerotic conditions.

Retracted: MicroRNA‐150 contributes to ischemic stroke through its effect on cerebral cortical neuron survival and function by inhibiting ERK1/2 axis via Mal

“…Consistent with our study, Sun et al () suggested that overexpressed miR‐150 is capable of decreasing p‐ERK1/2 protein expression but did not alter total ERK1/2 protein levels through inhibition of the GAB1‐ERK axis in hepatocellular carcinoma. Desjarlais, Dussault, Dhahri, Mathieu, and Rivard () found that the decreased level of miR‐150 exerts beneficial effects on the recuperation of blood flow following tissue ischemia. More important, Scherrer et al () also demonstrated in their study that log‐miR‐150‐5p is identified to be a newly discovered biomarker of clinical outcome among patients diagnosed with ischemic stroke, significantly correlated with survival rate within 90 days, positively affecting risk classification beyond traditional risk factors.…”

Role of endothelial microRNA-150 in pulmonary arterial hypertension

“…miR-150 and PTPMT1 may reduce maladaptive RV remodeling by augmentation of glucose oxidation and prevention of capillary rarefaction (Ryan & Archer, 2014). miR-150 has been shown to increase arteriolar density and improve blood flow in ischaemic heart tissues in mouse models of hypercholesterolemia (Desjarlais, Dussault et al, 2017). Consistently, we observed that miR-150 reduced expression of markers of cardiac hypertrophy and fibrosis, TGF-β, Col1a1, Rcan1 (Voelkel, Quaife et al, 2006) in Sugen/hypoxia mice.…”

MicroRNA‐150 restores endothelial cell function and attenuates vascular remodeling by targeting PTX3 through the NF‐κB signaling pathway in mice with acute coronary syndrome

“…A previous study highlighted the role of miR-150 as a tumor suppressor, which demonstrated that the reduced miR-150 expression triggers the telomerase activation of malignant lymphoma by activating the PI3 K/AKT signaling pathway (Watanabe et al, 2011). Previous findings from the study conducted by Desjarlais et al (2017) suggested that up-regulated expression of miR-150 could serve as a new therapeutic regimen in the improvement of ischemia induced neovascularization. has been hypothesized as a potential, biomarker of left ventricular remodeling after ST-segment-elevation acute myocardial infarction (Devaux et al, 2013).…”