2011
DOI: 10.1016/j.ijcard.2010.10.133
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MicroRNA-155 regulates lipid uptake, adhesion/chemokine marker secretion and SCG2 expression in oxLDL-stimulated dendritic cells/macrophages

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Cited by 33 publications
(31 citation statements)
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“…Our previous research had shown that miR-155 inhibited SRA expression and the JNK pathway (24), and JNK signaling has been demonstrated to control SRA expression in macrophages. Thus, we questioned whether miR-155 inhibited SRA expression through suppressing the JNK pathway.…”
Section: Negative Feedback and The Induction Of Mir-155 By Oxldlmentioning
confidence: 98%
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“…Our previous research had shown that miR-155 inhibited SRA expression and the JNK pathway (24), and JNK signaling has been demonstrated to control SRA expression in macrophages. Thus, we questioned whether miR-155 inhibited SRA expression through suppressing the JNK pathway.…”
Section: Negative Feedback and The Induction Of Mir-155 By Oxldlmentioning
confidence: 98%
“…1A). Subsequently, to explore the molecular basis underlying this upregulation, we used siRNA to knock down three scavenger receptors, SRA, CD36 and LOX-1, all of which are known to mediate endocytosis of oxLDL in macrophages (24), and then tested whether any of these scavenger receptors was involved in the upregulation of miR-155 by oxLDL in DCs. As shown in Fig.…”
Section: Mir-155 Is Upregulated By Oxldl Through Modulation Of Sra Anmentioning
confidence: 99%
“…Suppression of miR-155 in moDCs increased DC-SIGN expression and improved the binding of HIV protein gp-120 and Candida albicans (Martinez-Nunez et al, 2009). Similarly, miR-155 has been found to negatively regulate lipid uptake by human moDCs (Chen et al, 2011c). As miR-155 seems to play a negative role in binding/uptake of antigens, miR-146a in human monocytic cell line showed to increase phagocytosis of Escherichia coli (Pauley et al, 2011).…”
Section: Mirnas Regulate Effector Function By Modcsmentioning
confidence: 93%
“…Recently, two different research groups successively demonstrated that miR-155, another aberrantly expressed miRNA previously being suggested in Chen's research 17) , was also involved in negative feedback regulation of oxLDL-induced inflammation in macrophages via different signaling pathways 29,30) . As shown from previous research, MyD88 is a universal adapter protein used by Toll-like receptors to activate NF-κB signaling and hence mediates inflammatory responses 31) .…”
Section: Mirnas Modulate Oxldl-induced Signaling In Macrophagesmentioning
confidence: 99%
“…ND: not determined. expression of adhesion molecules 30) ; therefore, despite the conflicting data and the unidentified mechanisms underlying these effects, the above two researches give several interesting clues about miR-155 as an important epigenetic regulator of multiple oxLDL-induced signaling pathways in both macrophages and DCs (Fig. 2, 3).…”
Section: Fig 1 Epigenetic Regulation In Oxldl-stimulated Endotheliamentioning
confidence: 99%