MicroRNA‑15a‑5p inhibits endometrial carcinoma proliferation, invasion and migration via downregulation of VEGFA and inhibition of the Wnt/β‑catenin signaling pathway

Wang, Honggang; Yang, Qingju; Li, Jieping; Chen, Wenping; Jin, Xiaoyue; Wang, Yaowen

doi:10.3892/ol.2021.12570

Cited by 17 publications

(14 citation statements)

References 37 publications

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“…In lung adenocarcinoma, the expression of RUNX2 correlated with a poor hazard ratio, suggesting that RUNX2 plays a clinical role as an independent risk factor for poor survival in lung cancer [ 59 ]. A similar result demonstrated the positive correlation of elevated RUNX2 with poor overall survival of non-small-cell lung cancer patients [ 64 ]. RUNX2 expression was associated with adverse overall survival in a study of 301 renal cell carcinoma patients.…”

Section: Correlation With Clinical Outcomesupporting

confidence: 53%

RUNX2 and Cancer

Lin

2023

IJMS

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Runt-related transcription factor 2 (RUNX2) is critical for the modulation of chondrocyte osteoblast differentiation and hypertrophy. Recently discovered RUNX2 somatic mutations, expressional signatures of RUNX2 in normal tissues and tumors, and the prognostic and clinical significance of RUNX2 in many types of cancer have attracted attention and led RUNX2 to be considered a biomarker for cancer. Many discoveries have illustrated the indirect and direct biological functions of RUNX2 in orchestrating cancer stemness, cancer metastasis, angiogenesis, proliferation, and chemoresistance to anticancer compounds, warranting further exploration of the associated mechanisms to support the development of a novel therapeutic strategy. In this review, we focus mainly on critical and recent research developments, including RUNX2’s oncogenic activities, by summarizing and integrating the findings on somatic mutations of RUNX2, transcriptomic studies, clinical information, and discoveries about how the RUNX2-induced signaling pathway modulates malignant progression in cancer. We also comprehensively discuss RUNX2 RNA expression in a pancancer panel and in specific normal cell types at the single-cell level to indicate the potential cell types and sites for tumorigenesis. We expect this review to shed light on the recent mechanistical findings and modulatory role of RUNX2 in cancer progression and provide biological information that can guide new research in this field.

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Section: Correlation With Clinical Outcomesupporting

confidence: 53%

RUNX2 and Cancer

Lin

2023

IJMS

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“…The Wnt signaling pathway is one of the most important signaling pathways during development of a number of tumors and other diseases, including embryonic development and maturation of the central nervous system ( 34 , 35 ). Increasing evidence has indicated miRNA dysregulation and the Wnt/β-catenin signaling pathway jointly drive carcinogenesis, cancer metastasis and drug-resistance ( 36 – 40 ). The present study reported that miR-433 inactivated the Wnt/β-catenin signaling pathway by targeting TMED5 in NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Exosome‑derived microRNA‑433 inhibits tumorigenesis through incremental infiltration of CD4 and CD8 cells in non‑small cell lung cancer

et al. 2021

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Tumor-derived exosomal microRNAs (miRNAs/miRs) serve a vital biological role in tumorigenesis and development, but the effects and underlying mechanisms remain unclear. To explore the impact of exosomal miR-433 in non-small cell lung cancer (NSCLC) and understand its mechanism of action in NSCLC progression, the present study isolated the exosomes from the plasma of patients with NSCLC after chemotherapy and found that miR-433 expression was lower in plasma of patients with resistant NSCLC compared with in plasma of patients with sensitive NSCLC and in normal serum. Additionally, miR-433 expression was markedly negatively associated with a large tumor size, distant metastasis, advanced TNM stage and a poor prognosis in patients with NSCLC. miR-433 inhibited tumor growth by blocking the cell cycle in vitro and in vivo , as well as by promoting apoptosis and T-cell infiltration in the tumor microenvironment. Additionally, miR-433 inhibited chemoresistance to cisplatin by regulating DNA damage. Moreover, miR-433 inactivated the WNT/β-catenin signaling pathway by targeting transmembrane p24 trafficking protein 5 in NSCLC. Overall, the current findings may provide a potential prognostic biomarker and therapeutic target for patients with NSCLC.

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“…On the other hand, miR-652, miR-495, miR-1271, miR-381, and miR-29b have been identified as oncogenic miRNAs in EC (105,(154)(155)(156)160). Furthermore, miR-15a-5p and miR-589-5p were tumor suppressors in EC cells (161,164).…”

Section: Ec and Tumor Suppressor Mirnamentioning

confidence: 99%

The interplay of sex steroid hormones and microRNAs in endometrial cancer: current understanding and future directions

Thakur

Thakur²

2023

Front. Endocrinol.

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IntroductionEndometrial cancer is a hormone-dependent malignancy, and sex steroid hormones play a crucial role in its pathogenesis. Recent studies have demonstrated that microRNAs (miRNAs) can regulate the expression of sex steroid hormone receptors and modulate hormone signaling pathways. Our aim is to provide an overview of the current understanding of the role of miRNAs in endometrial cancer regulated by sex steroid hormone pathways.MethodsA thorough literature search was carried out in the PubMed database. The articles published from 2018 to the present were included. Keywords related to miRNAs, endometrial cancer, and sex steroid hormones were used in the search.ResultsDysregulation of miRNAs has been linked to abnormal sex steroid hormone signaling and the development of endometrial cancer. Various miRNAs have been identified as modulators of estrogen and progesterone receptor expression, and the miRNA expression profile has been shown to be a predictor of response to hormone therapy. Additionally, specific miRNAs have been implicated in the regulation of genes involved in hormone-related signaling pathways, such as the PI3K/Akt/mTOR and MAPK/ERK pathways.ConclusionThe regulation of sex steroid hormones by miRNAs is a promising area of research in endometrial cancer. Future studies should focus on elucidating the functional roles of specific miRNAs in sex steroid hormone signaling and identifying novel miRNA targets for hormone therapy in endometrial cancer management.

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MicroRNA‑15a‑5p inhibits endometrial carcinoma proliferation, invasion and migration via downregulation of VEGFA and inhibition of the Wnt/β‑catenin signaling pathway

Cited by 17 publications

References 37 publications

RUNX2 and Cancer

RUNX2 and Cancer

Exosome‑derived microRNA‑433 inhibits tumorigenesis through incremental infiltration of CD4 and CD8 cells in non‑small cell lung cancer

The interplay of sex steroid hormones and microRNAs in endometrial cancer: current understanding and future directions

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