MicroRNA-181b is downregulated in non-small cell lung cancer and inhibits cell motility by directly targeting HMGB1

Liu, Yun; Hu, Xu; Xia, Daokui; Zhang, Songlin

doi:10.3892/ol.2016.5198

Cited by 23 publications

(26 citation statements)

References 37 publications

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“…In NSCLC cell lines, it was also demonstrated that miR-181b overexpression sensitized multidrug-resistant cells to cisplatin-induced apoptosis by targeting BCL2 [45]. Moreover, miR-181b has also been shown to inhibit migration and invasion of NSCLC by directly targeted high-mobility group box-1 (HMGB1) [46].…”

Section: Non-small Cell Lung Cancer (Nsclc)mentioning

confidence: 99%

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

Indrieri

Carrella

Carotenuto

et al. 2020

IJMS

116

110

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MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the regulation of gene expression. Evidence accumulating in the past decades indicate that they are capable of simultaneously modulating diverse signaling pathways involved in a variety of pathophysiological processes. In the present review, we provide a comprehensive overview of the function of a highly conserved group of miRNAs, the miR-181 family, both in physiological as well as in pathological conditions. We summarize a large body of studies highlighting a role for this miRNA family in the regulation of key biological processes such as embryonic development, cell proliferation, apoptosis, autophagy, mitochondrial function, and immune response. Importantly, members of this family have been involved in many pathological processes underlying the most common neurodegenerative disorders as well as different solid tumors and hematological malignancies. The relevance of this miRNA family in the pathogenesis of these disorders and their possible influence on the severity of their manifestations will be discussed. A better understanding of the miR-181 family in pathological conditions may open new therapeutic avenues for devasting disorders such as neurodegenerative diseases and cancer.

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Section: Non-small Cell Lung Cancer (Nsclc)mentioning

confidence: 99%

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

Indrieri

Carrella

Carotenuto

et al. 2020

IJMS

116

110

View full text Add to dashboard Cite

show abstract

“…Moreover, a lot of studies have manifested that HMGB1 can induce malignant phenotypes of cancer cells by promoting EMT . Overexpression of HMGB1 indicates a poor survival rate in many cancer types such as hepatocellular carcinoma and non‐small–cell lung cancer (NSCLC) . miR‐181b is downregulated in NSCLC and can inhibit cell motility by targeting HMGB1 .…”

Section: Discussionmentioning

confidence: 99%

“…25,26 Overexpression of HMGB1 indicates a poor survival rate in many cancer types such as hepatocellular carcinoma and non-small-cell lung cancer (NSCLC). [27][28][29] miR-181b is downregulated in NSCLC and can inhibit cell motility by targeting HMGB1. 30 miR-325 can inhibit hepatocellular carcinoma progression by targeting HMGB1.…”

Section: Discussionmentioning

confidence: 99%

miR‐505 acts as a tumor suppressor in gastric cancer progression through targeting HMGB1

Tian

Wang

Hao

et al. 2018

J of Cellular Biochemistry

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Gastric cancer (GC) is a frequent type of malignant tumor worldwide. GC metastasis results in the majority of clinical treatment failures. MicroRNAs (miRNA) are identified to exhibit crucial roles in GC. Our current study aimed to explore the biological roles of miR‐505 in GC progression. It was observed that miR‐505 was robustly decreased in GC cells compared with human normal gastric epithelial GES‐1 cells. Overexpression of miR‐505 was able to repress GC progression in AGS and BGC‐823 cells. In addition, high‐mobility group box 1 (HMGB1) has been identified as a crucial oncogene in several cancer types. By carrying out bioinformatics analysis, HMGB1 was predicted as a direct target of miR‐505. Meanwhile, HMGB1 was found to be significantly increased in GC cells and it was confirmed in our study that miR‐505 can directly target HMGB1 in vitro. miR‐505 mimics can inhibit HMGB1 messenger RNA and protein expression dramatically. Subsequently, knockdown of HMGB1 can inhibit GC cell proliferation, colony formation, and induce cell apoptosis. Furthermore, HMGB1 silence suppressed GC cell migration and invasion greatly in vitro. Finally, it was validated that miR‐505 can inhibit GC progression by targeting HMGB1 in vivo. Taken these together, it was indicated that miR‐505/HMGB1 axis was involved in the development of GC. miR‐505 can serve as a potential prognostic indicator in GC therapy.

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“…Changes in these epigenetic factors result in the dysregulation of key oncogenes and tumor suppressor genes [18,19]. Many of the epigenetic events in lung cancer affect cancer hallmarks, such as proliferation [20][21][22][23], invasion [24][25][26], metastasis [27][28][29][30][31][32][33], apoptosis [34][35][36][37], and cell cycle regulation. In addition to cancer hallmarks, several important signaling pathways are affected by epigenetic deregulation in lung cancer, such as the ERK family, the NF-kB signaling pathway, and the Hedgehog signaling pathway [18].…”

Section: Epigenetic Landscape In Lungmentioning

confidence: 99%

Current Landscape of Epigenetics in Lung Cancer: Focus on the Mechanism and Application

Shi

Sheng

Cheng

et al. 2019

Journal of Oncology

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Lung cancer is the leading cause of cancer-related mortality worldwide. Tumorigenesis involves a multistep process resulting from the interactions of genetic, epigenetic, and environmental factors. Genome-wide association studies and sequencing studies have identified many epigenetic alterations associated with the development of lung cancer. Epigenetic mechanisms, mainly including DNA methylation, histone modification, and noncoding RNAs (ncRNAs), are heritable and reversible modifications that are involved in some important biological processes and affect cancer hallmarks. We summarize the major epigenetic modifications in lung cancer, focusing on DNA methylation and ncRNAs, their roles in tumorigenesis, and their effects on key signaling pathways. In addition, we describe the clinical application of epigenetic biomarkers in the early diagnosis, prognosis prediction, and oncotherapy of lung cancer. Understanding the epigenetic regulation mechanism of lung cancer can provide a new explanation for tumorigenesis and a new target for the precise treatment of lung cancer.

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MicroRNA-181b is downregulated in non-small cell lung cancer and inhibits cell motility by directly targeting HMGB1

Cited by 23 publications

References 37 publications

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

miR‐505 acts as a tumor suppressor in gastric cancer progression through targeting HMGB1

Current Landscape of Epigenetics in Lung Cancer: Focus on the Mechanism and Application

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