MicroRNA-186 regulates the invasion and metastasis of bladder cancer via vascular endothelial growth factor C

He, Xuefeng; Ping, Jigen; Di, Wen

doi:10.3892/etm.2017.4908

Cited by 27 publications

(29 citation statements)

References 24 publications

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“…It has been shown that VEGFC participated in the development of various cancers. He et al reported that miR‐186 regulated bladder cancer metastasis via VEGFC . Lin et al showed that brain derived neurotrophic factor promoted VEGFC‐dependent lymphangiogenesis through inhibition of miR‐624‐3p in chondrosarcoma cells in vitro .…”

Section: Discussionmentioning

confidence: 99%

LncRNA MIAT facilitates osteosarcoma progression by regulating mir‐128‐3p/VEGFC axis

et al. 2019

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The aberrant expression of long non‐coding RNAs (lncRNAs) has been involved in the progression of many human tumors including osteosarcoma (OS). However, the biological function and the underlying mechanism of the lncRNA myocardial infarction‐associated transcript (MIAT) in OS remain unclear. In the present study, we found that lncRNA MIAT was significantly up‐regulated in both OS tissues and cell lines, and high expression of MIAT was positively associated with tumor size and lymph node metastasis of OS patients. In addition, knockdown of MIAT inhibited proliferation, migration, invasion and promoted apoptosis of OS cells in vitro. Moreover, the expression of MIAT was negatively associated with miR‐128‐3p but positively correlated with vascular endothelial growth factor C (VEGFC) in OS. Further mechanistic study revealed that lncRNA MIAT promoted OS progression by up‐regulating VEGFC via sponging miR‐128‐3p in vitro. Taken together, our results suggest that MIAT/miR‐128‐3p/VEGFC axis contributes to OS progression and may be used as a novel therapeutic target for OS. © 2019 IUBMB Life, 9999(9999):1–9, 2019

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Section: Discussionmentioning

confidence: 99%

LncRNA MIAT facilitates osteosarcoma progression by regulating mir‐128‐3p/VEGFC axis

et al. 2019

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“…Yang and his colleagues concluded that the upregulation of miR-186 in bladder cancer tissue samples in comparison with corresponding para-cancerous samples after a TCGA data analysis, further verified upregulation of miR-186 in bladder cancer cells in comparison with normal human uroepithelial cells (25). However, two groups reported downregulation of miR-186 in bladder cancer tissues and cells (26,27). Colorectal cancer is the third most common cancer in the world (62…”

Section: Altered Expressions Of Mir-186 In Different Cancersmentioning

confidence: 97%

“…In bladder cancer, miR-186 markedly repressed cell proliferation and metastasis by targeting NSBP1 (also known as HMGN5) (26), which can bind to nucleosomes with its nucleosomal-binding domain to make chromatin unfold, regulating the expression of many genes (74). VEGF-C was also a target through which miR-186 repressed invasion and migration of bladder cancer cells (27). In colorectal cancer, Li et al reported that miR-186 repressed cell proliferation, EMT, and migration by targeting ZEB1, a key member of the ZEB family, which were important in regulation of EMT in various cancer cells (29).…”

Section: Mir-186 As a Tumor Suppressor Mirnamentioning

confidence: 99%

The Dual Role of miR-186 in Cancers: Oncomir Battling With Tumor Suppressor miRNA

et al. 2020

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MicroRNAs (miRNAs) are a class of small non-coding RNAs which regulate gene expression at post-transcriptional level. Alterations of miR-186 expression were demonstrated in numerous cancers, shown to play a vital role in oncogenesis, invasion, metastasis, apoptosis, and drug resistance. MiR-186 was documented as a tumor suppressor miRNA in the majority of studies, while conflicting reports verified miR-186 as an oncomir. The contradictory role in cancers may impede the application of miR-186, as well as other dual-functional miRNAs, as a diagnostic and therapeutic target. This review emphasizes the alterations and functions of miR-186 in cancers and discusses the mechanisms behind the contradictory findings. Among these, target abundance and dose-dependent effects of miR-186 are highlighted. The paper aims to review the challenges involved in developing diagnostic and therapeutic strategies for cancer treatment based on dual-functional miRNAs.

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“…For example, Ding et al (26) reported that miR-367 regulates cell proliferation and metastasis by targeting metastasis-associated protein 3 in clear-cell renal cell carcinoma. He et al (27) indicated that miR-186 regulates the invasion and metastasis of bladder cancer via vascular endothelial growth factor C. Notably, a recent study demonstrated that miR-6852 overexpression induces necrosis in cervical cancer cells (13). However, the role of miR-6852 in other tumors remains elusive.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑6852 suppresses cell proliferation and invasion via targeting forkhead box J1 in gastric cancer

Zhang

et al. 2018

Exp Ther Med

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Accumulating evidence suggests that microRNAs (miRs) exert vital functions in the development and progression of multiple types of human cancer. However, the role of miR-6852 in gastric cancer (GC) remains unclear. In the present study, miR-6852 expression was significantly downregulated in GC tissues compared with adjacent normal tissues determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis. Furthermore, miR-6852 expression levels in patients with GC were reversely correlated with tumor metastasis and TNM stage. Through Cell Counting kit-8 and Transwell assays, it was demonstrated that overexpression of miR-6852 significantly inhibited the proliferation, migration and invasion of GC cells. With regards to the mechanism involved, luciferase reporter assays suggested that miR-6852 directly target forkhead box J1 (FOXJ1) in GC cells. Furthermore, overexpression of miR-6852 markedly inhibited the mRNA and protein expression levels of FOXJ1 in GC cells determined by RT-qPCR and western blot analysis. Additionally, FOXJ1 was overexpressed in GC tissues and cell lines, and its expression was negatively correlated with that of miR-6852 in GC tissues. Rescue assays indicated that overexpression of FOXJ1 significantly reversed the effects of miR-6852 transfection on GC cell proliferation, migration and invasion. Taken together, the present findings demonstrated that miR-6852 exerted a tumor suppressive role through targeting FOXJ1 in GC. These results implied that miR-6852 may be a novel therapeutic target of GC treatment.

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MicroRNA-186 regulates the invasion and metastasis of bladder cancer via vascular endothelial growth factor C

Abstract: Abstract. The present study aimed to investigate the expression of microRNA (miRNA or miR)-186 in tumor tissue, blood and urine from patients with bladder cancer. The mechanism by which miR-186 regulates the invasion and metastasis of bladder cancer was also assessed.

Cited by 27 publications

References 24 publications

LncRNA MIAT facilitates osteosarcoma progression by regulating mir‐128‐3p/VEGFC axis

LncRNA MIAT facilitates osteosarcoma progression by regulating mir‐128‐3p/VEGFC axis

The Dual Role of miR-186 in Cancers: Oncomir Battling With Tumor Suppressor miRNA

MicroRNA‑6852 suppresses cell proliferation and invasion via targeting forkhead box J1 in gastric cancer

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