MicroRNA-19 (miR-19) Regulates Tissue Factor Expression in Breast Cancer Cells

Zhang, Xiaoxi; Yu, Haijun; Lou, Jessica R.; Zheng, Jie; Zhu, Hua; Popescu, Narcis I.; Lupu, Florea; Lind, Stuart E.; Ding, Wei

doi:10.1074/jbc.m110.146530

Cited by 131 publications

(107 citation statements)

References 45 publications

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“…It has been reported that miRs exhibits anti-carcinoma effect on tumor growth by interfering with the expression of Jun B and Jun D [19]. miR 19 suppresses the expression of tissue factor which is involved in the progress of tumors [20]. The results from the present study revealed increase in the expression of tumor suppressor genes on exposure to wortmannin.…”

Section: Discussionsupporting

confidence: 69%

Wortmannin as Targeted Therapeutic Agent for the Treatment of Triple-Negative Breast Cancer

Li¹,

Liu²,

Liu³

et al. 2016

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 69%

Wortmannin as Targeted Therapeutic Agent for the Treatment of Triple-Negative Breast Cancer

Li¹,

Liu²,

Liu³

et al. 2016

Trop. J. Pharm Res

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“…15 Moreover, the expression of miR-19 was significantly higher in the lessinvasive breast cancer MCF7 cells than the more-invasive MDAMB-231 cells, and the expression of a positive regulator of tumor angiogenesis and metastasis was negatively regulated by miR-19 in breast cancer cells, 35 suggesting that miR-19 inhibited the metastasis of breast cancer. In osteosarcoma cells, the expression of miR-19a was higher in metastatic LM7 cells with low expression of Fas than the parental nonmetastatic SAOS-2 cells with high expression of Fas.…”

Section: Discussionmentioning

confidence: 95%

MicroRNA-19 triggers epithelial–mesenchymal transition of lung cancer cells accompanied by growth inhibition

Yang

Yan

et al. 2015

Laboratory Investigation

103

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The miR-19 family (miR-19a and miR-19b-1) are key oncogenic components of the miR-17-92 cluster. Overexpression of miR-19 is strongly associated with cancer invasion and metastasis, and poor prognosis of cancer patients. However, the underlying mechanisms remain largely unknown. In the present study, we found that enforced expression of miR-19 including miR-19a and miR-19b-1 triggered epithelial-mesenchymal transition (EMT) of lung cancer cells A549 and HCC827 as shown by mesenchymal-like morphological conversion, downregulation of epithelial proteins (e.g., E-cadherin, ZO-1 (zona occludens 1), and α-catenin), upregulation of mesenchymal proteins (e.g., vimentin, fibronectin 1, N-cadherin, and snail1), formation of stress fibers, and reduced cell adhesion. In addition, enhanced migration and invasion were observed in the cancer cells A549 and HCC827 undergoing EMT. In contrast, silencing of endogenous miR-19 reversed EMT and reduced the migration and invasion abilities of A549 and HCC827 cells. DNA microarray results revealed significant changes of the expression of genes related to EMT, migration, and metastasis of miR-19-expressing A549 cells. Moreover, siRNA-mediated knockdown of PTEN, a target of miR-19, also resulted in EMT, migration, and invasion of A549 and HCC827 cells, suggesting that PTEN is involved in miR-19-induced EMT, migration and invasion of lung cancer cells. Furthermore, lung cancer cells undergoing EMT induced by miR-19 demonstrated reduced proliferation in vitro and in vivo, and enhanced resistance to apoptosis caused by TNF-α. Taken together, these findings suggest that miR-19 triggers EMT, which has an important role in the invasion and migration of lung cancer cells, accompanied by the reduced proliferation of cells.

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“…Only decrypted TF can exert its procoagulant activity, while encrypted TF still has the ability to transmit signals. It was recently found that a microRNA (miR-19) could bind to 3'-UTR of the TF transcript to repress translation in breast cancer cells (Zhang et al 2010). This study showed that miR-19 is abundant in a TF low-expressing breast cancer cell line, MCF-7, suggesting that regulation by this microRNA may be a determinant of TF levels in breast cancer tissues.…”

Section: Expression Of Tf Activity In Breast Cancer Tissuesmentioning

confidence: 99%

Ectopic Synthesis of Coagulation Factor VII in Breast Cancer Cells: Mechanisms, Functional Correlates, and Potential for a New Therapeutic Target

Koizume¹,

Miyagi²

2011

Breast Cancer - Current and Alternative Therapeutic Modalities

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MicroRNA-19 (miR-19) Regulates Tissue Factor Expression in Breast Cancer Cells

Cited by 131 publications

References 45 publications

Wortmannin as Targeted Therapeutic Agent for the Treatment of Triple-Negative Breast Cancer

Wortmannin as Targeted Therapeutic Agent for the Treatment of Triple-Negative Breast Cancer

MicroRNA-19 triggers epithelial–mesenchymal transition of lung cancer cells accompanied by growth inhibition

Ectopic Synthesis of Coagulation Factor VII in Breast Cancer Cells: Mechanisms, Functional Correlates, and Potential for a New Therapeutic Target

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