MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells

Xu, Chi; Liu, Shanshan; Fu, Hanjiang; Li, Shuai; Tao, Yi; Zhu, Jie; Xing, Ruiyun; Jin, Yinghua; Sun, Zhixian; Zheng, Xiaofei

doi:10.1016/j.ejca.2010.06.127

Cited by 134 publications

(103 citation statements)

References 21 publications

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“…Hypoxia-sensitive miR-200b is involved in induction of angiogenesis via directly targeting Ets1 in endothelial cells (39). Ectopic expression of miR193b dramatically suppresses the proliferation, migration, and invasion of hepatocellular carcinoma cells by targeting Ets1 and cyclin D1 (40). Overexpression of miR-1 and miR-499 in hepatocellular carcinoma cells downregulates the Ets1 expression via direct targeting the 3 0 -UTR, resulting in decreased invasion and migration (41).…”

Section: ) Ets1 Is Also Implicated In Vascularizationmentioning

confidence: 99%

miRNA-145 Targets v-ets Erythroblastosis Virus E26 Oncogene Homolog 1 to Suppress the Invasion, Metastasis, and Angiogenesis of Gastric Cancer Cells

Zheng

et al. 2013

Molecular Cancer Research

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Recent evidence shows that v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) is implicated in tumor development and progression. However, the clinical potentials and underlying mechanisms of Ets1 in gastric cancer progression and metastasis remain largely unknown. In this study, Ets1 immunostaining was identified in 56 of 84 (66.7%) gastric cancer tissues, which was correlated with tumor invasion and metastasis. In gastric cancer specimens and cell lines, miRNA-145 (miR-145) was downregulated and inversely correlated with Ets1 expression. Bioinformatics analysis and luciferase reporter assay revealed that miR-145 directly targeted the 3 0 -untranslated region (3 0 -UTR) of Ets1 mRNA. Overexpression or knockdown of miR-145 responsively altered both the mRNA and protein levels of Ets1 and its downstream genes, matrix metalloproteinase (MMP-1)-1 and -9, in gastric cancer cell lines SGC-7901 and MKN-45. Ectopic expression of miR-145 suppressed the invasion, metastasis, and angiogenesis of SGC-7901 and MKN-45 cells in vitro and in vivo. In addition, the effects of miR-145 on Ets1 expression, migration, invasion, and angiogenesis were rescued by restoration of Ets1 expression in these cells. Furthermore, anti-miR-145 inhibitor promoted the migration, invasion, and angiogenesis, whereas siRNAmediated Ets1 knockdown phenocopied the effects of miR-145 overexpression in gastric cancer cells. These results show that miR-145 suppresses Ets1 expression via the binding site in the 3 0 -UTR, thus inhibiting the invasion, metastasis, and angiogenesis of gastric cancer cells. Mol Cancer Res; 11(2); 182-93. Ó2012 AACR.

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Section: ) Ets1 Is Also Implicated In Vascularizationmentioning

confidence: 99%

miRNA-145 Targets v-ets Erythroblastosis Virus E26 Oncogene Homolog 1 to Suppress the Invasion, Metastasis, and Angiogenesis of Gastric Cancer Cells

Zheng

et al. 2013

Molecular Cancer Research

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“…One example is cyclin D1, which is regulated by miR449a [35] , miR-193b [36] , miR-15/16 [37][38][39] , miR-19a [40] , miR-195 [41] , and miR-302a [42] . The cyclin D1 binding proteins CDK4 and CDK6 are also regulated by a number of miRNAs, including miR-107 [43] , miR-449a [44] , miR-129 [45] , miR-125b [46] , miR-15/16 [39] , miR-24 [47] , miR-195 [41] , and miR-124a [48] .…”

Section: Mir-34 Familymentioning

confidence: 99%

Macro-management of microRNAs in cell cycle progression of tumor cells and its implications in anti-cancer therapy

Liang

2011

Acta Pharmacol Sin

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The cell cycle, which is precisely controlled by a number of regulators, including cyclins and cyclin-dependent kinases (CDKs), is crucial for the life cycle of mammals. Cell cycle dysregulation is implicated in many diseases, including cancer. Recently, compelling evidence has been found that microRNAs play important roles in the regulation of cell cycle progression by modulating the expression of cyclins, CDKs and other cell cycle regulators. Herein, the recent findings on the regulation of the cell cycle by microRNAs are summarized, and the potential implications of miRNAs in anti-cancer therapies are discussed.

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“…17,18 Our group first demonstrated that overexpression of miR193b represses cell proliferation and arrests cells in G1 by targeting cyclin D in melanoma cells. 15 More recently, Xu et al 19 demonstrated that miR-193b targets cyclin D in hepatocellular carcinoma cells and regulates proliferation, migration, and invasion.…”

mentioning

confidence: 99%

miR-193b Regulates Mcl-1 in Melanoma

Chen

Zhang

Lentz

et al. 2011

The American Journal of Pathology

101

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MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells

Cited by 134 publications

References 21 publications

miRNA-145 Targets v-ets Erythroblastosis Virus E26 Oncogene Homolog 1 to Suppress the Invasion, Metastasis, and Angiogenesis of Gastric Cancer Cells

miRNA-145 Targets v-ets Erythroblastosis Virus E26 Oncogene Homolog 1 to Suppress the Invasion, Metastasis, and Angiogenesis of Gastric Cancer Cells

Macro-management of microRNAs in cell cycle progression of tumor cells and its implications in anti-cancer therapy

miR-193b Regulates Mcl-1 in Melanoma

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