MicroRNA-195-5p regulates carbon monoxide releasing molecule-3-induced osteogenic differentiation of rat bone marrow mesenchymal stem cells by targeting Wnt3a
Abstract:Background and Purpose: Bone marrow-derived mesenchymal stem cells (BMSCs) are potential in promoting bone regeneration for their multipotential differentiation capacity. Our previous study showed that carbon monoxide releasing molecule-3 (CORM-3) promoted the osteogenic differentiation of rat BMSCs. However, the mechanism was not clearly understood. MicroRNAs (miRNAs) play a critical role in regulating the osteogenic differentiation of BMSCs. We therefore investigated the role of miR-195-5p in CORM-3-induced … Show more
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