MicroRNA-196a-5p targeting LRP1B modulates phenotype of thyroid carcinoma cells

Abstract

circRNA_0000140 on the growth and metastasis of oral squamous cell carcinoma [11]. MicroRNA-146b-5p hampers metastasis and tumourigenesis of gallbladder cancer by targeting Toll-like receptor 4 via the nuclear factor-κB pathway [12]. MicroRNA-133b can suppress colorectal cancer metastasis by lncRNA LUCAT1 [13]. MicroR-NA-196a-5p is a conserved microRNA derived from its precursor . MicroRNA-196a-5p has been studied in diseases including non-small cell lung cancer [15], cataracts [16], and gastric cancer [17]. However, in TC, the effect and specific mechanism of microR-NA-196a-5p remain unclear.Low-density lipoprotein receptor-associated protein 1 (LRP1) is a multifunctional receptor involved in many biological processes, including signal transduction, lipoprotein metabolism, regulation of vascular permeability and tension, cell growth, migration, and apoptosis [18]. LRP1B is a tumour suppressor that encodes LDL receptor [19]. LRP1B was originally discovered based on a homozygous deletion analysis in human lung cancer cell lines [20]. LRP1B is a member