MicroRNA-197 promotes proliferation and inhibits apoptosis of gallbladder cancer cells by targeting insulin-like growth factor-binding protein 3

Li, Tong; Zuo, He-ping; Li, Jingrong

doi:10.17219/acem/134833

Cited by 6 publications

(1 citation statement)

References 25 publications

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“… 43 We did not find any correlation of miR-197-3p expression with OS, PFS, and response to therapy. In contrast, higher expression of miR-197 was associated with poor prognosis in gallbladder cancer 44 and NSCLC. 45 We found a significantly lower expression of miR-197-3p in LUAD tumors compared with LUSC tumors, a finding consistent with another study in NSCLC.…”

Section: Discussionmentioning

confidence: 88%

Analysis of miR-375-3p, miR-197-3p, and miR-15a-5p Expression and Their Clinical Relevance as Biomarkers in Lung Cancer

Kumar

Saikia

Sharawat

et al. 2022

Technol Cancer Res Treat

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Background: MicroRNAs (miRNAs) play an important regulatory role and serve as biomarkers in various human cancers. However, their role in the prognosis and predicting response to therapy in Indian lung cancer patients is not fully explored. Methods: We collected surgically resected tumors and paired adjacent normal lung tissues from 29 early-stage and tissue biopsies from 103 locally advanced and metastatic lung cancer patients in this prospective study. We quantified the expression levels of miR-375-3p, miR-197-3p, and miR-15a-5p using TaqMan Advanced miRNA Assays. We correlated miRNAs expression with response to therapy and survival outcomes. Results: The median age of lung cancer patients was 60 years. We found significant overexpression of miR-375-3p and miR-197-3p in the tumors compared to paired normal lung tissues. Higher expression of miR-375-3p was observed more frequently in responders compared to nonresponders. The expression of miR-375-3p and miR-197-3p was able to differentiate patients of lung adenocarcinoma from lung squamous cell carcinoma. We did not find any correlation between miRNAs expression and survival outcomes. Conclusion: Overexpression of miR-375-3p and miR-197-3p might contribute to lung carcinogenesis. The expression of miR-375-3p may assist in predicting therapeutic response. More prospective studies are warranted to evaluate the potential of miR-375-3p as a predictive biomarker of response to therapy.

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Section: Discussionmentioning

confidence: 88%