MicroRNA-206 in human cancer: Mechanistic and clinical perspectives

Khasraghi, Leila Bahari; Nouri, Morteza; Vazirzadeh, Masoud; Hashemipour, Nasrin; Talebi, Mehrdad; Zarch, Fatemehsadat Aghaei; Majidpoor, Jamal; Kalhor, Kambiz; Farnia, Poopak; Najafi, Sajad; Zarch, Seyed Mohsen Aghaei

doi:10.1016/j.cellsig.2022.110525

Cited by 27 publications

(10 citation statements)

References 126 publications

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“…MicroRNAs (miRNAs) are small noncoding RNAs of approximately 22 nucleotide (nt) that are known to have a significant role in the regulation of the post-transcriptional level of messenger RNAs (mRNAs) [ 1 , 2 ]. MiRNAs are 22 nt noncoding RNAs recognized to play a crucial function in the post-transcriptional control of mRNA [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

et al. 2023

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MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including cancer. Among the miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, and miR-424 have been extensively studied in various cancers. Although research in miRNAs has grown considerably over the last decade, much is yet to be discovered, especially regarding their role in cancer therapies. Several kinds of cancer have been linked to dysregulation and abnormal expression of miR-122, indicating that miR-122 may serve as a diagnostic and/or prognostic biomarker for human cancer. Consequently, in this review literature, miR-122 has been analyzed in numerous cancer types to sort out the function of cancer cells miR-122 and enhance patient response to standard therapy.

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Section: Introductionmentioning

confidence: 99%

MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

et al. 2023

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“…Non-coding RNA (ncRNA) is an emerging biomarker that exhibits correlations with tumorigenesis and possesses oncogenic or tumour-suppressing properties. It can be detected in serum, plasma, and other biological fluids, making it a promising therapeutic and prognostic target for tumours, due to its non-invasive nature traumatic, high sensitivity, and specificity [ 108 – 110 ]. The ncRNAs, including long ncRNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), are extensively involved in tumour pathogenesis.…”

Section: The Influence Of Non-coding Rnas On Xrccmentioning

confidence: 99%

X-ray cross-complementing family: the bridge linking DNA damage repair and cancer

Liu,

Peng,

Zhang

et al. 2023

J Transl Med

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Genomic instability is a common hallmark of human tumours. As a carrier of genetic information, DNA is constantly threatened by various damaging factors that, if not repaired in time, can affect the transmission of genetic information and lead to cellular carcinogenesis. In response to these threats, cells have evolved a range of DNA damage response mechanisms, including DNA damage repair, to maintain genomic stability. The X-ray repair cross-complementary gene family (XRCC) comprises an important class of DNA damage repair genes that encode proteins that play important roles in DNA single-strand breakage and DNA base damage repair. The dysfunction of the XRCC gene family is associated with the development of various tumours. In the context of tumours, mutations in XRCC and its aberrant expression, result in abnormal DNA damage repair, thus contributing to the malignant progression of tumour cells. In this review, we summarise the significant roles played by XRCC in diverse tumour types. In addition, we discuss the correlation between the XRCC family members and tumour therapeutic sensitivity.

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“…They regulate gene expression post-transcriptionally by binding directly to the 3'UTRs of target mRNAs [17]. It is estimated that miRNAs may regulate up to one-third of human genes [18].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Elastase induced Abdominal Aortic Aneurysm Progression through the CXCL12/CXCR4 Axis via MiR206 3p Sponge

Xuan,

Li,

Cao

et al. 2024

Preprint

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Background Prior research has established a significant association between the progression of abdominal aortic aneurysms (AAA) and the apoptosis and phenotypic transformation of vascular smooth muscle cells (VSMCs). Notably, the CXCL12/CXCR4 signaling pathway's activation is markedly increased in a mouse model of AAA. Nonetheless, the precise contribution of this pathway to AAA development remains to be elucidated. Materials and Methods We utilized a single-cell sequencing dataset pertaining to AAA from the Gene Expression Omnibus database, employing the R package CellChat (v1.1.3) to analyze communication strength, signaling pathways, and modes of interaction among various VSMC phenotypes and immune cells. The activity level of the CXCL12/CXCR4 axis was evaluated in both human AAA patients and a mouse model. We examined the impact of CXCR4-specific inhibitors on AAA progression and the regulatory influence of MiR206-3p sponge on this axis. Results Single-cell RNA sequencing analysis revealed a significant upregulation of CXCL12/CXCR4 axis in AAA tissues. Further, Serum ELISA and in vivo experiments indicate a pronounced activation of the CXCL12/CXCR4 axis in both AAA patients and the elastase-induced AAA mouse model. CXCR4-specific inhibitors inhibited further expansion and rupture of the abdominal aorta and reduced the infiltration of macrophages in the aorta. Diminishing miR206-3p levels in VSMCs led to a decrease in CXCR4 expression within AAA tissues and a reduction in serum CXCL12 concentrations. Furthermore, transfecting VSMCs with miR206-3p sponge curtailed apoptosis and phenotypic transformation, markedly reducing AAA diameter and rupture frequency in mice. In vitro experiments corroborated that blocking the CXCL12/CXCR4 axis mitigated apoptosis and phenotypic transformation of VSMCs. Conclusion Our findings propose that MiR206-3p sponge represents an innovative therapeutic strategy to attenuate AAA progression and rupture risk, primarily through the suppression of the CXCL12/CXCR4 signaling pathway.

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MicroRNA-206 in human cancer: Mechanistic and clinical perspectives

Cited by 27 publications

References 126 publications

MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

X-ray cross-complementing family: the bridge linking DNA damage repair and cancer

Inhibition of Elastase induced Abdominal Aortic Aneurysm Progression through the CXCL12/CXCR4 Axis via MiR206 3p Sponge

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