microRNA-21 Aggravates Lipopolysaccharide-Induced Inflammation in MH7A Cells Through Targeting SNF5

Wu, Shupeng; Wang, Jing; Li, Jun; Li, Fang

doi:10.1007/s10753-019-01117-8

Cited by 9 publications

(5 citation statements)

References 44 publications

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“…miR-21 exerts its role by negatively regulating a cell proliferation protein suppressor, SNF5. Exogenous addition of SNF5, a transcription regulatory protein, reduced p-NF-κBp65, p-IκB-α, p-PI3K, and p-Akt proteins, thereby suppressing the inflammatory response ( 60 ).…”

Section: Three Most Published Mirnas In Rheumatic Diseases: Mir-146 M...mentioning

confidence: 99%

“…For example, through miR-21 mimic and inhibitor transfection studies, Wu et al. found that miR-21 promoted LPS-induced inflammatory responses in the MH7A cell line by activating NF-κB and PTEN/PI3K/AKT pathways via silencing the tumor suppressor gene SNF5 ( 60 ). Geest et al.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

“…The effects of miR-21 are cell-type specific. For example, through miR-21 mimic and inhibitor transfection studies, Wu et al found that miR-21 promoted LPSinduced inflammatory responses in the MH7A cell line by activating NF-kB and PTEN/PI3K/AKT pathways via silencing the tumor suppressor gene SNF5 (60). Geest et al showed that miR-21 has higher expression in the T-reg cells with a memory phenotype from the synovial fluid of RA patients in comparison with the conventional T-reg cells isolated from the peripheral blood of RA patients.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

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Challenges and promise of targeting miRNA in rheumatic diseases: a computational approach to identify miRNA association with cell types, cytokines, and disease mechanisms

Shaikh,

Siegel,

Srivastava

et al. 2024

Front. Immunol.

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MicroRNAs (miRNAs) are small non-coding RNAs that alter the expression of target genes at the post-transcriptional level, influencing diverse outcomes in metabolism, cell differentiation, proliferation, cell survival, and cell death. Dysregulated miRNA expression is implicated in various rheumatic conditions, including ankylosing spondylitis (AS), gout, juvenile idiopathic arthritis (JIA), osteoarthritis (OA), psoriatic arthritis, rheumatoid arthritis (RA), Sjogren’s syndrome, systemic lupus erythematosus (SLE) and systemic sclerosis. For this review, we used an open-source programming language- PowerShell, to scan the massive number of existing primary research publications on PubMed on miRNAs in these nine diseases to identify and count unique co-occurrences of individual miRNAs and the disease name. These counts were used to rank the top seven most relevant immuno-miRs based on their research volume in each rheumatic disease. Individual miRNAs were also screened for publication with the names of immune cells, cytokines, and pathological processes involved in rheumatic diseases. These occurrences were tabulated into matrices to identify hotspots for research relevance. Based on this information, we summarize the basic and clinical findings for the top three miRNAs — miR-146, miR-155, and miR-21 — whose relevance spans across multiple rheumatic diseases. Furthermore, we highlight some unique miRNAs for each disease and why some rheumatic conditions lack research in this emerging epigenetics field. With the overwhelming number of publications on miRNAs in rheumatic diseases, this review serves as a ‘relevance finder’ to guide researchers in selecting miRNAs based on the compiled existing knowledge of their involvement in disease pathogenesis. This approach applies to other disease contexts with the end goal of developing miRNA-based therapeutics.

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Section: Three Most Published Mirnas In Rheumatic Diseases: Mir-146 M...mentioning

confidence: 99%

Section: Rheumatoid Arthritismentioning

confidence: 99%

Section: Rheumatoid Arthritismentioning

confidence: 99%

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Challenges and promise of targeting miRNA in rheumatic diseases: a computational approach to identify miRNA association with cell types, cytokines, and disease mechanisms

Shaikh,

Siegel,

Srivastava

et al. 2024

Front. Immunol.

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show abstract

“…However, some miRNAs have a negative role in promoting inflammation. miR-21 restores Treg/Th17 cell balance in T cells, whereas it silences SNF5 in FLS cells, leading to the activation of the NF-κB and phosphoinositide 3-kinase (PI3K)/protein Kinase B (Akt) signaling pathway and the enhancement of cell proliferation [ 112 ]. The dysregulation of miR-128-3p represses its target histone deacetylase 4 (HDAC4) and activates the AKT/ mammalian target of rapamycin (mTOR) pathway to disturb various activities of FLS cells [ 113 ].…”

Section: Role Of Mirnas In Ra Developmentmentioning

confidence: 99%

“… [ 34 ] miR-21 ↑ FLS SNF5 ↑ NF-κB activation; ↑ PTEN/PI3K/AKT pathway; ↑ inflammation; ↑ cell proliferation. [ 112 ] miR-21 ↓ PBMC N/A ↓ ESR and CRP; ↓ DAS28 score; ↓ disease activity. [ 109 ] miR-23a ↓ Chondrocytes IKKα ↓IL-17; ↓NF-κB activation.…”

Section: Table A1mentioning

confidence: 99%

Role of miRNAs in Rheumatoid Arthritis Therapy

Zhang

Yang

Xie

et al. 2023

Cells

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Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by autoimmunity, synovial inflammation and joint destruction. Pannus formation in the synovial cavity can cause irreversible damage to the joint and cartilage and eventually permanent disability. Current conventional treatments for RA have limitations regarding efficacy, safety and cost. microRNA (miRNA) is a type of non-coding RNA (ncRNA) that regulates gene expression at the post-transcriptional level. The dysregulation of miRNA has been observed in RA patients and implicated in the pathogenesis of RA. miRNAs have emerged as potential biomarkers or therapeutic agents. In this review, we explore the role of miRNAs in various aspects of RA pathophysiology, including immune cell imbalance, the proliferation and invasion of fibroblast-like synovial (FLS) cell, the dysregulation of inflammatory signaling and disturbance in angiogenesis. We delve into the regulatory effects of miRNAs on Treg/Th17 and M1/M2 polarization, the activation of the NF-κB/NLRP3 signaling pathway, neovascular formation, energy metabolism induced by FLS-cell-induced energy metabolism, apoptosis, osteogenesis and mobility. These findings shed light on the potential applications of miRNAs as diagnostic or therapeutic biomarkers for RA management. Furthermore, there are some strategies to regulate miRNA expression levels by utilizing miRNA mimics or exosomes and to hinder miRNA activity via competitive endogenous RNA (ceRNA) network-based antagonists. We conclude that miRNAs offer a promising avenue for RA therapy with unlimited potential.

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Compounds DRG and DAG, Two Phenol Glycosides, Inhibit TNF-α-stimulated Inflammatory Response through Blocking NF-kB/AKT/JNK Signaling Pathways in MH7A Cells

et al. 2021

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microRNA-21 Aggravates Lipopolysaccharide-Induced Inflammation in MH7A Cells Through Targeting SNF5

Cited by 9 publications

References 44 publications

Challenges and promise of targeting miRNA in rheumatic diseases: a computational approach to identify miRNA association with cell types, cytokines, and disease mechanisms

Challenges and promise of targeting miRNA in rheumatic diseases: a computational approach to identify miRNA association with cell types, cytokines, and disease mechanisms

Role of miRNAs in Rheumatoid Arthritis Therapy

Compounds DRG and DAG, Two Phenol Glycosides, Inhibit TNF-α-stimulated Inflammatory Response through Blocking NF-kB/AKT/JNK Signaling Pathways in MH7A Cells

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