2019
DOI: 10.3892/ol.2019.10002
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MicroRNA‑21 and its impact on signaling pathways in cervical cancer (Review)

Abstract: Oncogenic microRNA-21 (miR-21/miRNA-21) is a stable inhibitor of gene expression that is often upregulated in cervical cancer, a disease that affects the health of women and tends to transform and spread. Previous studies investigating miR-21 in biopsies and cells from cervical cancer patients have identified that miR-21 binds target mRNAs in signaling pathways or long non-coding RNAs (lncRNA). Furthermore, studies have elucidated the molecular mechanisms of two tumor necrosis factor α (TNF-α) signaling pathwa… Show more

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Cited by 9 publications
(7 citation statements)
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“…The miR-21 is proposed to be an anti-apoptotic element that appears to inhibit caspase activity and regulate apoptosis by regulating the gene expressions of TNF-α, PTEN, RAS, and PI3K. Therefore, this element has been referred to as an oncogene in various cancers [37]. In the present study, testicular I/R significantly reduced miR-21 levels in rat testes cells.…”
Section: Discussionsupporting
confidence: 51%
“…The miR-21 is proposed to be an anti-apoptotic element that appears to inhibit caspase activity and regulate apoptosis by regulating the gene expressions of TNF-α, PTEN, RAS, and PI3K. Therefore, this element has been referred to as an oncogene in various cancers [37]. In the present study, testicular I/R significantly reduced miR-21 levels in rat testes cells.…”
Section: Discussionsupporting
confidence: 51%
“…Currently, there are several review articles that have illustrated the association between miR-21 expression and human malignancies [e.g. melanoma ( 22 ), osteosarcoma ( 23 ), cervical cancer ( 24 ), and pancreatic cancer ( 25 )], central nervous system disorders ( 26 ), arthritis ( 27 ), and skin diseases ( 28 ). Whereas, there is currently no relevant review article addressing the clinical implications and the underlying molecular mechanisms of miR-21 in DN, so a comprehensive review of all the current evidence on this issue is warranted.…”
Section: Overview Of Mir-21 In a Variety Of Diseasesmentioning
confidence: 99%
“…The most common genetic alteration activating PI3K is the genetic ablation of the tumor suppressor phosphatase and tensin homolog (PTEN), a negative regulator of PI3K-AKT signaling (39). miR-21 is one of the most frequently observed abnormal miRNAs in human cancers and is one of the first miRNAs described as oncogenic ncRNA (40)(41)(42)(43)(44). A large-scale miRNA analysis of 540 samples from six different types of solid tumors showed that miR-21 is the only up-regulated miRNA in all cancer types (45).…”
Section: Pi3k-akt Signal Pathwaymentioning
confidence: 99%