MicroRNA-21 Is a Versatile Regulator and Potential Treatment Target in Central Nervous System Disorders

Bai, Xue; Bian, Zhigang

doi:10.3389/fnmol.2022.842288

Cited by 38 publications

(31 citation statements)

References 138 publications

(144 reference statements)

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“…Upregulation of α-synuclein expression is promoted by miR-148a in a DNMT1-dependent manner [ 524 , 560 ]. Furthermore, miR-21, which is significantly upregulated in diabetic β cells [ 525 , 526 , 527 , 528 , 529 , 530 , 531 ], targets lysosome-associated membrane protein type 2A ( LAMP2A ) and thus reduces chaperone-mediated autophagy [ 561 , 562 ], thus linking α-synuclein toxicity to the pathogenesis of T2DM and Parkinson’s disease [ 524 , 563 ].…”

Section: Discussionmentioning

confidence: 99%

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life

Melnik

Schmitz

2022

IJMS

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Pancreatic β cell expansion and functional maturation during the birth-to-weaning period is driven by epigenetic programs primarily triggered by growth factors, hormones, and nutrients provided by human milk. As shown recently, exosomes derived from various origins interact with β cells. This review elucidates the potential role of milk-derived exosomes (MEX) and their microRNAs (miRs) on pancreatic β cell programming during the postnatal period of lactation as well as during continuous cow milk exposure of adult humans to bovine MEX. Mechanistic evidence suggests that MEX miRs stimulate mTORC1/c-MYC-dependent postnatal β cell proliferation and glycolysis, but attenuate β cell differentiation, mitochondrial function, and insulin synthesis and secretion. MEX miR content is negatively affected by maternal obesity, gestational diabetes, psychological stress, caesarean delivery, and is completely absent in infant formula. Weaning-related disappearance of MEX miRs may be the critical event switching β cells from proliferation to TGF-β/AMPK-mediated cell differentiation, whereas continued exposure of adult humans to bovine MEX miRs via intake of pasteurized cow milk may reverse β cell differentiation, promoting β cell de-differentiation. Whereas MEX miR signaling supports postnatal β cell proliferation (diabetes prevention), persistent bovine MEX exposure after the lactation period may de-differentiate β cells back to the postnatal phenotype (diabetes induction).

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Section: Discussionmentioning

confidence: 99%

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life

Melnik

Schmitz

2022

IJMS

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“…RNA-induced silencing complex is quite a novel part of epigenetics applicable in medicine, nutritional science, metabolomics, and genomics and, in combination with bioinformatics, represents a big scientific potential for the future. For this reason, methods, techniques, and algorithms will be on the increase [ 139 , 140 , 141 , 142 , 143 ].…”

Section: Current Approaches For Functional Identification Of Mirnas I...mentioning

confidence: 99%

The Involvement of microRNAs in Plant Lignan Biosynthesis—Current View

Ražná¹,

Harenčár²,

Kučka³

2022

Cells

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Lignans, as secondary metabolites synthesized within a phenylpropanoid pathway, play various roles in plants, including their involvement in growth and plant defense processes. The health and nutritional benefits of lignans are unquestionable, and many studies have been devoted to these attributes. Although the regulatory role of miRNAs in the biosynthesis of secondary metabolites has been widely reported, there is no systematic review available on the miRNA-based regulatory mechanism of lignans biosynthesis. However, the genetic background of lignan biosynthesis in plants is well characterized. We attempted to put together a regulatory mosaic based on current knowledge describing miRNA-mediated regulation of genes, enzymes, or transcription factors involved in this biosynthesis process. At the same time, we would like to underline the fact that further research is necessary to improve our understanding of the miRNAs regulating plant lignan biosynthesis by exploitation of current approaches for functional identification of miRNAs.

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“…Currently, there are several review articles that have illustrated the association between miR-21 expression and human malignancies [e.g. melanoma ( 22 ), osteosarcoma ( 23 ), cervical cancer ( 24 ), and pancreatic cancer ( 25 )], central nervous system disorders ( 26 ), arthritis ( 27 ), and skin diseases ( 28 ). Whereas, there is currently no relevant review article addressing the clinical implications and the underlying molecular mechanisms of miR-21 in DN, so a comprehensive review of all the current evidence on this issue is warranted.…”

Section: Overview Of Mir-21 In a Variety Of Diseasesmentioning

confidence: 99%

MicroRNA-21: A Critical Pathogenic Factor of Diabetic Nephropathy

Liu

Wu²,

Liao

et al. 2022

Front. Endocrinol.

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Diabetic nephropathy (DN), one of the most common and intractable microvascular complications of diabetes, is the main cause of terminal renal disease globally. MicroRNA-21 (miR-21) is a kind of miRNA early identified in human circulation and tissues. Mounting studies have demonstrated that miR-21 plays an important role in the development and progression of DN. This collaborative review aimed to present a first attempt to capture the current evidence on the relationship between miR-21 and DN. After a systematic search, 29 relevant studies were included for comprehensively and thoroughly reviewing. All these eligible studies reported that miR-21 was up-regulated in DN, whether in serum or renal tissues of human or animal models. MiR-21 exhibited its pathogenic roles in DN by forming a complex network with targeted genes (e.g. MMP-9, Smad7, TIMP3, Cdk6, FOXO1, IMP3, and MMP2) and the signaling cascades (e.g. Akt/TORC1 signaling axis, TGF-β/NF-κB signaling pathways, TGF-β/SMAD pathway, CADM1/STAT3 signaling, and AGE-RAGE regulatory cascade), which resulted in epithelial-to-mesenchymal transition, extracellular matrix deposition, cytoskeletal remodeling, inflammation, and fibrosis. This review highlights that miR-21 is a pivotal pathogenic factor in the development of DN. It may serve as an attractive potential diagnostic, prognostic, and predictive biomarker for DN in clinical practice after further confirmation of the clinicopathological features and molecular mechanisms of miR-21-mediated DN.

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MicroRNA-21 Is a Versatile Regulator and Potential Treatment Target in Central Nervous System Disorders

Cited by 38 publications

References 138 publications

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life

The Involvement of microRNAs in Plant Lignan Biosynthesis—Current View

MicroRNA-21: A Critical Pathogenic Factor of Diabetic Nephropathy

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