MicroRNA-21, microRNA-181a and microRNA-196a as potential biomarkers in adult Egyptian patients with systemic lupus erythematosus

Motawi, Tarek K.; Mohsen, Dahlia A.; El-Maraghy, Shohda A.; Kortam, Mona A.

doi:10.1016/j.cbi.2016.11.001

Cited by 27 publications

(22 citation statements)

References 30 publications

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“…However, five articles were excluded by reading their complete articles due to article types, seven studies lacked available data to construct a 2×2 table, and four articles lacked a comparison between SLE patients and healthy controls. Finally, 17 studies [17][18][19][20][21][31][32][33][34][35][36][37][38][39][40][41][42] were included in the meta-analysis. The process of study selection was illustrated in Fig 1. Except the study of Zununi Vahed et al [42] is a cross-sectional trial, all others are prospective trials.…”

Section: Search Resultsmentioning

confidence: 99%

“…In 2011, Stagaki et al [16] suggested that miRNA-21 (miR-21) was a potential biomarker for SLE. Since then, a series of studies [17][18][19][20][21] have also verified the role of miR-21 in SLE. In addition, these studies [18][19][20][21] have found other miRNAs (miR-155, -181a, -196a, -31, and -148a) dysregulated in SLE.…”

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confidence: 99%

“…Since then, a series of studies [17][18][19][20][21] have also verified the role of miR-21 in SLE. In addition, these studies [18][19][20][21] have found other miRNAs (miR-155, -181a, -196a, -31, and -148a) dysregulated in SLE. Dai et al [22] carried out a meta-analysis to verify the diagnostic accuracy of miRNAs as potential biomarkers for SLE.…”

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confidence: 99%

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Diagnostic significance of circulating miRNAs in systemic lupus erythematosus

et al. 2019

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BackgroundIn recent years, many studies focused on the association between the microRNAs (miR-NAs) and the risk of systemic lupus erythematosus (SLE), especially miRNA-21 (miR-21). We aimed to investigate the role of circulating miRNAs, especially the miR-21, as a biomarker in detecting SLE. MethodsWe searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and China National Knowledge Infrastructure through Mar 3th, 2019. We performed this metaanalysis in a fixed/random-effect model using Meta-disc 1.4 and STATA 15.1. ResultsA total of 17 relevant studies were eligible to analyze pooled accuracy. The overall performance of total mixed miRNAs (TmiRs) detection was: pooled sensitivity, 0.71 (95% confidence interval [CI], 0.69 to 0.72); pooled specificity, 0.81 (95%CI, 0.79 to 0.83); and area under the summary receiver operating characteristic curves value (SROC), 0.8797. The miR-21 detection was: pooled sensitivity, 0.68 (95%CI, 0.62 to 0.74); pooled specificity, 0.77 (95%CI, 0.69 to 0.84); and SROC, 0.8281. The meta-regression analysis showed that the type of samples was the sources of heterogeneity. The subgroup analysis suggested that detection in plasma group had the largest AUC of SROC in all the subgroups: pooled sensitivity, 0.8 (95%CI, 0.78 to 0.82); pooled specificity, 0.83 (95%CI, 0.8 to 0.86); and SROC, 0.9068. ConclusionsOur meta-analysis demonstrated that circulating miRNAs might be potential novel biomarkers for detecting SLE, especially miR-21. Moreover, plasma is recommended as the clinical specimen for diagnostic detection.

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Section: Search Resultsmentioning

confidence: 99%

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confidence: 99%

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Diagnostic significance of circulating miRNAs in systemic lupus erythematosus

et al. 2019

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“…miR‐196a exhibited good sensitivity and specificity (area under the curve [AUC] = 0.76) in discriminating SLE patients from healthy controls. Multivariate analysis revealed that miRNA‐21 and miRNA‐196a were significant independent risk factors for disease progression …”

Section: Plasma Microrna Biomarkersmentioning

confidence: 99%

“…When we searched PubMed, Medline and Embase databases for original English‐language articles published in 2016 using the following search terms (title or abstract), ‘systemic lupus erythematous’ OR ‘SLE’ OR ‘lupus nephritis’ OR ‘LN’ and ‘biomarkers’ OR ‘RNA’ OR ‘protein’ OR ‘metabolites’ that focused only on human studies, 31 articles satisfied these criteria. From these, 17 publications that had utilized the largest sample sizes ( n ≥ 70) are summarized in Table . Highlights from these studies are summarized below.…”

Section: Introductionmentioning

confidence: 99%