microRNA-21 promotes breast cancer proliferation and metastasis by targeting LZTFL1

Wang, Hui; Tan, Zhongping; Hu, Hui; Liu, Hongzhou; Wu, Tangwei; Zheng, Chao; Wang, Xiuling; Luo, Zhenzhao; Wang, Jing; Liu, Shuiyi; Lu, Zhongxin; Tu, Jiancheng

doi:10.1186/s12885-019-5951-3

Cited by 207 publications

(153 citation statements)

References 40 publications

Supporting

Mentioning

127

Contrasting

Unclassified

Order By: Relevance

“…This indicates their dysfunction may have very crucial impacts on the development of cancers. For instance, miR-21 ranked as the top one in the three cancers, has been confirmed highly involved in cancer proliferation and metastasis (Liu H. et al, 2018;Wang et al, 2019). On the other hand, we find that the most influenced genes by the dysfunctional miRNAs are highly related with cancers, such as CDK2, TP53, HRAS, NFKB1 (Carroll et al, 2000;Normanno et al, 2009;Xu et al, 2016).…”

Section: Only a Few Mirnas Have Significant Global Influences On Cancersmentioning

confidence: 59%

A Systematic Way to Infer the Regulation Relations of miRNAs on Target Genes and Critical miRNAs in Cancers

et al. 2020

Front. Genet.

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are a class of important non-coding RNAs, which play important roles in tumorigenesis and development by targeting oncogenes or tumor suppressor genes. One miRNA can regulate multiple genes, and one gene can be regulated by multiple miRNAs. To promote the clinical application of miRNAs, two fundamental questions should be answered: what's the regulatory mechanism of a miRNA to a gene, and which miRNAs are important for a specific type of cancer. In this study, we propose a miRNA influence capturing (miRNAInf) to decipher regulation relations of miRNAs on target genes and identify critical miRNAs in cancers in a systematic approach. With the pair-wise miRNA/gene expression profiles data, we consider the assigning problem of a miRNA on target genes and determine the regulatory mechanisms by computing the Pearson correlation coefficient between the expression changes of a miRNA and that of its target gene. Furthermore, we compute the relative local influence strength of a miRNA on its target gene. Finally, integrate the local influence strength and target gene's importance to determine the critical miRNAs involved in specific cancer. Results on breast, liver and prostate cancers show that positive regulations are as common as negative regulations. The top-ranked miRNAs show great potential as therapeutic targets driving cancer to a normal state, and they are demonstrated to be closely related to cancers based on biological functional analysis, drug sensitivity/resistance analysis and survival analysis. This study will be helpful for the discovery of critical miRNAs and development of miRNAs-based clinical therapeutics.

show abstract

Section: Only a Few Mirnas Have Significant Global Influences On Cancersmentioning

confidence: 59%

A Systematic Way to Infer the Regulation Relations of miRNAs on Target Genes and Critical miRNAs in Cancers

et al. 2020

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…The dysregulation of miRNAs was involved in cancer biology. For example, miR-21 can promote the proliferation and migration of breast cancer via targeting LZTFL1, 26 and miR-221 can promote the proliferation of cutaneous squamous cell carcinoma by targeting PTEN. 27 In NSCLC, the expression of miR-221 and miR-10a were up-regulated, and their overexpression could accelerate the proliferation, migration and invasion of cancer cells.…”

Section: Discussionmentioning

confidence: 99%

<p>Up-Regulation of FSTL3, Regulated by lncRNA DSCAM-AS1/miR-122-5p Axis, Promotes Proliferation and Migration of Non-Small Cell Lung Cancer Cells</p>

Gao¹,

Chen²,

Wang³

et al. 2020

OTT

View full text Add to dashboard Cite

Background: Follistatin-like 3 (FSTL3) binds and inactivates activin, a growth factor with cell growth and differentiation. Previous studies reported that it is overexpressed in invasive breast cancers, and its expression and function in non-small cell lung cancer (NSCLC) remain unclear. Materials and Methods: Immunohistochemistry was employed to probe the expression of FSTL3 in NSCLC tissues. Real-time PCR (RT-PCR) was applied to detect the expression of lncRNA DSCAM-AS1 and miR-122-5p. A549 cells and H1299 cells were used as cell models. The biological influence of FSTL3 on cells was studied using CCK-8 assay, wound healing assay and transwell assay in vitro, respectively. In vivo subcutaneous xenotransplanted tumor model and tail vein injection model in mice were also constructed to validate the roles of FSTL3. Interactions between miR-122-5p and FSTL3, DSCAM-AS1 and miR-122-5p were determined by bioinformatics analysis, RT-PCR, and dual-luciferase reporter assay. Results: FSTL3 and DSCAM-AS1 were remarkably up-regulated in NSCLC samples, and miR-122-5p was down-regulated. FSTL3 was associated with worse prognosis of NSCLC patients. FSTL3 knockdown markedly inhibited the viability, migration and invasion of NSCLCs in vitro and in vivo. DSCAM-AS1 could down-regulate miR-122-5p via sponging it, and FSTL3 was a target gene of miR-122-5p. Conclusion: Taken together, our study identified that FSTL3 was a new oncogene of NSCLC, which was regulated by DSCAM-AS1 and miR-122-5p. These findings suggested that FSTL3, DSCAM-AS1 and miR-122-5p might serve as a new valuable therapeutic target for NSCLC.

show abstract

“…25 miR-21 enhances the PLF and MTS of breast cancer cells by targeting LZTFL1. 26 In GC, miRNAs have been found to play various regulatory roles in cell PLF, MGT, multidrug resistance, etc For example, miR-4268 represses the PLF of GC cells by targeting Rab6B 27 ; miR-107 modulates the growth and MGT of GC cells by down-regulating FAT4 to activate PI3K-AKT signaling pathway 28 ; miR-200c reverses the cisplatin resistance of GC by targeting NER-ERCC3/4. 29 Reportedly, miR-141-3p expression is down-regulated in multiple tumors.…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA HCG18 up‐regulates the expression of WIPF1 and YAP/TAZ by inhibiting miR‐141‐3p in gastric cancer

et al. 2020

View full text Add to dashboard Cite

Background Accumulating works show that lncRNAs play critical roles in the development of gastric cancer (GC). LncRNA HLA complex group 18 (HCG18) was implicated in the progression of bladder cancer and glioma, but its role in GC is unknown. Methods RT‐PCR was used to detect HCG18 and miR‐141‐3p expression in GC specimen. GC cell lines (AGS and MKN‐28) were exploited as cell model. The biological effect of HCG18 on cancer cells was probed by CCK‐8, colony formation, flow cytometry, Transwell and wound‐healing experiments in vitro, and subcutaneous xenotransplanted tumor model and tail vein injection model in vivo. Interaction between HCG18 and miR‐141‐3p was determined by bioinformatics analysis, RT‐PCR, and luciferase reporter experiments. Downstream gene expression of miR‐141‐3p, including Wiskott–Aldrich syndrome protein interacting protein family member 1 (WIPF1), Yes associated protein 1 (YAP), and tafazzin (TAZ) were detected using Western blot. Results HCG18 was markedly up‐regulated in GC specimens, while miR‐141‐3p was markedly down‐regulated. Down‐regulation of HCG18 inhibited viability, migration, and invasion of GC cells, while miR‐141‐3p transfection led to opposite effect. HCG18 could down‐regulate miR‐141‐3p through adsorbing it, and a negative association between HCG18 and miR‐141‐3p was found in GC specimens. HCG18 promoted WIPF1, YAP and TAZ expression, nonetheless, such influence was reversed by co‐transfecting with miR‐141‐3p. Conclusion HCG18 was aberrantly up‐regulated in GC tissues, and it indirectly regulated the activity of Hippo signaling through counteracting miR‐141‐3p expression.

show abstract

microRNA-21 promotes breast cancer proliferation and metastasis by targeting LZTFL1

Cited by 207 publications

References 40 publications

A Systematic Way to Infer the Regulation Relations of miRNAs on Target Genes and Critical miRNAs in Cancers

A Systematic Way to Infer the Regulation Relations of miRNAs on Target Genes and Critical miRNAs in Cancers

<p>Up-Regulation of FSTL3, Regulated by lncRNA DSCAM-AS1/miR-122-5p Axis, Promotes Proliferation and Migration of Non-Small Cell Lung Cancer Cells</p>

Long noncoding RNA HCG18 up‐regulates the expression of WIPF1 and YAP/TAZ by inhibiting miR‐141‐3p in gastric cancer

Contact Info

Product

Resources

About