MicroRNA-214 Suppresses Growth and Invasiveness of Cervical Cancer Cells by Targeting UDP-N-acetyl-α-d-galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 7

Peng, Ruiqing; Wan, Haisu; Li, Haifang; Liu, Min; Li, Xin; Tang, Hua

doi:10.1074/jbc.m111.337642

Cited by 154 publications

(131 citation statements)

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“…It was recently determined that microRNAs may play a role in the cellular response to radiotherapy [10,11]. miR-214 is an important miRNA that has been investigated in various tumor types and aberrantly expressed in various cancers and involved in the progress of malignant tumors [12][13][14][15][16]. miR-214 has been previously shown to promote the chemoresistance of human ovarian cancer [17,18].…”

Section: Introductionmentioning

confidence: 99%

miR-214 promotes radioresistance in human ovarian cancer cells by targeting PETN

Zhang

2017

Bioscience Reports

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Correspondence: Shuxiang Zhang (zhang sx19@163.com) Ovarian cancer is one of the leading causes of death among gynecological malignancies. Increasing evidence indicate that dysregulation of microRNAs (miRNAs) plays an important role in tumor radioresistance. The aim of the present study is to investigate whether microRNA-214 (miR-214) was involved in radioresistance of human ovarian cancer. Here, we showed that miR-214 was significantly up-regulated in ovarian cancer tissues and radioresistance ovarian cancer cell lines. Transfection of miR-214 agomir in radiosensitive ovarian cancer cell lines promoted them for resistance to ionizing radiation, whereas transfection of miR-214 antagomir in radioresistance ovarian cancer cell lines sensitized them to ionizing radiation again. Furthermore, we found miR-214 effectively promoted tumor radioresistance in xenograft animal experiment. Western blotting and quantitative real-time PCR demonstrated that miR-214 negatively regulated PTEN in radioresistance ovarian cancer cell lines and ovarian cancer tissues. Taken together, our data conclude that miR-214 contributes to radioresistance of ovarian cancer by directly targeting PTEN.

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Section: Introductionmentioning

confidence: 99%

miR-214 promotes radioresistance in human ovarian cancer cells by targeting PETN

Zhang

2017

Bioscience Reports

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“…Previous reports from other labs and our lab have shown that many miRNAs are aberrantly expressed in cervical cancer and that miRNAs can act as tumor suppressors (e.g., miR-302-367, miR-424, miR-214) [9][10][11][12] or enhancers (e.g., miR-205, miR-21, miR-19a/b) [13][14][15]. Although some progress has been achieved in the past decades, much more effort is needed to elucidate the occurrence and mechanism of cervical cancer.…”

Section: Introductionmentioning

confidence: 65%

MicroRNA‐7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells

et al. 2013

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Edited by Tamas DalmayKeywords: microRNA microRNA-7 X-linked inhibitor of apoptosis protein Cell apoptosis Cervical cancer a b s t r a c t Our study demonstrated the functions of microRNA-7 (miR-7) in cervical cancer. The overexpression of miR-7 in the cervical cancer cell lines HeLa and C-33A suppressed cell viability and promoted cell apoptosis, whereas the inhibition of miR-7 had opposite effects. Furthermore, an oncogene, Xlinked inhibitor of apoptosis protein (XIAP), was identified as a new target of miR-7, and the ectopic expression of XIAP rescued the effects induced by miR-7 in HeLa and C-33A cells. These results indicate that miR-7 targeted and downregulated the oncogene XIAP to regulate the effect of miR-7 on apoptosis and malignant behaviors of HeLa and C-33A cells.

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“…Initiation of O-glycosylation is carried out by a family of GALNT sialyltransferase enzymes, including GALNT7, which catalyse the transfer of GalNAc to serine/threonine residues on target proteins to produce the Tn antigen (GalNAc-O-Ser/Thr) (Ten Hagen et al 2003). GALNT7 has been identified as oncogene in several types of cancer (Gaziel-Sovran et al 2011, Peng et al 2012, Li et al 2014b, …”

Section: Androgens Control O-glycan Biosynthesismentioning

confidence: 99%

“…Initiation of O-glycosylation Identified as oncogene in several types of cancer and controlled by micro-RNAs (Gaziel-Sovran et al , Peng et al 2012, Li et al 2014b, Nie et al 2015, Lu et al 2016 Upregulated in malignant PCa as part of a glycosylation gene signature (Barfeld et al 2014a). Androgen regulated and linked to prostate cancer cell viability ) GCNT1…”

Section: :3mentioning

confidence: 99%

Glycosylation is a global target for androgen control in prostate cancer cells

Munkley¹

2017

Endocrine-Related Cancer

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Changes in glycan composition are common in cancer and can play important roles in all of the recognised hallmarks of cancer. We recently identified glycosylation as a global target for androgen control in prostate cancer cells and further defined a set of 8 glycosylation enzymes (GALNT7, ST6GalNAc1, GCNT1, UAP1, PGM3, CSGALNACT1, ST6GAL1 and EDEM3), which are also significantly upregulated in prostate cancer tissue. These 8 enzymes are under direct control of the androgen receptor (AR) and are linked to the synthesis of important cancer-associated glycans such as sialyl-Tn (sTn), sialyl LewisX (SLeX), O-GlcNAc and chondroitin sulfate. Glycosylation has a key role in many important biological processes in cancer including cell adhesion, migration, interactions with the cell matrix, immune surveillance, cell signalling and cellular metabolism. Our results suggest that alterations in patterns of glycosylation via androgen control might modify some or all of these processes in prostate cancer. The prostate is an abundant secretor of glycoproteins of all types, and alterations in glycans are, therefore, attractive as potential biomarkers and therapeutic targets. Emerging data on these often overlooked glycan modifications have the potential to improve risk stratification and therapeutic strategies in patients with prostate cancer.

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MicroRNA-214 Suppresses Growth and Invasiveness of Cervical Cancer Cells by Targeting UDP-N-acetyl-α-d-galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 7

Cited by 154 publications

References 43 publications

miR-214 promotes radioresistance in human ovarian cancer cells by targeting PETN

miR-214 promotes radioresistance in human ovarian cancer cells by targeting PETN

MicroRNA‐7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells

Glycosylation is a global target for androgen control in prostate cancer cells

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