MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia

Jiang, Wenjie; Min, Jie; Sui, Xiaohui; Qian, Yanyan; Liu, Ying; Liu, Zhaojian; Zhou, Haibin; Li, Xi; Gong, Yaoqin

doi:10.3109/10428194.2014.924115

Cited by 37 publications

(22 citation statements)

References 49 publications

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“…Like in hepatoblastoma, AML and multiple myeloma, in this study, miR‐26a‐5p was also found downregulated in breast cancer, and low expression of miR‐26a‐5p predicted a negative index for the overall survival of breast cancer patients (Figure ). Overexpression of miR‐26a‐5p markedly inhibited breast cancer cell growth, and decreased the expression levels of cell cycle‐associated proteins (Figure ), which suggested that miR‐26a‐5p was a potential biomarker for breast cancer.…”

Section: Discussionsupporting

confidence: 57%

“…MiR‐26a‐5p targeted the 3′‐untranslated regions of LIN28B and AURKA, and markedly inhibited their expressions, along with suppressing hepatoblastoma cell growth and clonality . In acute myeloid leukemia (AML), miR‐26a‐5p was found downregulated by a miRNA expression assay, and peroxiredoxin III (PrxIII) was identified as a direct target of miR‐26a‐5p . In this study, miR‐26a‐5p targeted ring finger protein 6 (RNF6) mRNA and inhibited its gene expression in breast cancer cells.…”

Section: Introductionmentioning

confidence: 81%

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MicroRNA‐26a‐5p inhibits breast cancer cell growth by suppressing RNF6 expression

Huang

Yang

et al. 2019

The Kaohsiung J of Med Scie

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MicroRNA-26a-5p (miR-26a-5p) has been reported to be involved in the tumorigenesis of several tumors, but its function in breast cancer is still unknown. In this study, miR-26a-5p was found significantly downregulated in both of the breast cancer tissues and cell lines, and low expression of miR-26a-5p predicted a poor prognosis for breast cancer patients. Overexpression of miR-26a-5p could significantly inhibit breast cancer cell growth. Further studies revealed that overexpression of miR-26a-5p downregulated the protein levels of Cyclin D1, CDK4, and CDK6, but upregulated the expression levels of p21, p27, and p53. In mechanism, miR-26a-5p targeted the 3 0 UTR of ring finger protein 6 (RNF6) mRNA and inhibited RNF6 expression in breast cancer cells.Moreover, overexpression of miR-26a-5p inhibited RNF6/ERα/Bcl-xL axis in breast cancer cells. In contrast, inhibiting miR-26a-5p upregulated RNF6/ERα/Bcl-xL axis.Further studies indicated that miR-26a-5p mediated RNF6/ERα/Bcl-xL axis through regulating the stability of ERα protein. Collectively, downregulation of miR-26a-5p plays essential roles in breast cancer by mediating RNF6/ERα/Bcl-xL axis, which might provide important implications for the therapeutics of breast cancer.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 81%

MicroRNA‐26a‐5p inhibits breast cancer cell growth by suppressing RNF6 expression

Huang

Yang

et al. 2019

The Kaohsiung J of Med Scie

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“…In the present study, overexpression of miRNA-23b-3p also increased oxidative stress in neurocyte cell by high-glucose. Jiang et al reported that microRNA-23b-3p up-regulate reactive oxygen species (ROS) and oxidative stress in acute myeloid leukemia (19).…”

Section: Discussionmentioning

confidence: 99%

Sirt1/Nrf2 signalling pathway prevents cognitive impairment in diabetic rats through anti‑oxidative stress induced by miRNA‑23b‑3p expression

et al. 2018

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In the present study the exact roles and mechanisms underlying the effect of miRNA‑23b‑3p on the cognitive impairment of diabetic rats were investigated. The in vivo model of diabetes was established in Wistar rats via a single injection of streptozotocin (STZ). Cognitive function was evaluated using a Morris water maze test. Oxidative stress was measured using ELISA kits, and the protein expression levels of B‑cell lymphoma 2‑associated X protein, silent information regulator 1 (SIRT1), nuclear factor erythroid 2‑related factor 2 (Nrf2) and GAPDH were measured by western blot analysis. Micro (mi)RNA‑23b‑3p mimics were employed to increase miRNA‑23b‑3p expression in the in vitro model. Overexpression of miRNA‑23b‑3p increased oxidative stress (as indicated by the levels of glutathione peroxidase, glutathione, superoxide dismutase and malondialdehyde) and apoptosis in neurocytes following high‑glucose treatment. The overexpression of miRNA‑23b‑3p also suppressed SIRT1 and Nrf2 expression in neurocytes following high‑glucose treatment; it also promoted the SIRT1‑induced inhibition of apoptosis and oxidative stress. The promotion of SIRT1 also decreased the effect of miRNA‑23b‑3p on cognitive impairment in diabetic rats. In conclusion, miRNA‑23b‑3p prevents the cognitive impairment of diabetic rats via anti‑oxidative stress effects and the Sirt1/Nrf2 signaling pathway.

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“…The accumulation of peroxiredoxin III caused by decreased miR-26a leads to a marked reduction in reactive oxygen species (ROS) in primary AML granulocyte samples ( 83 ). Growing evidence demonstrates that ROS plays a key role in regulating the balance between self-renewal and differentiation of HSCs ( 84 ).…”

Section: Emerging Roles Of Mirna Deregulation In the Pathogenesis Ofmentioning

confidence: 99%

MicroRNA, an Antisense RNA, in Sensing Myeloid Malignancies

2018

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Myeloid malignancies, including myelodysplastic syndromes and acute myeloid leukemia, are clonal diseases arising in hematopoietic stem or progenitor cells. In recent years, microRNA (miRNA) expression profiling studies have revealed close associations of miRNAs with cytogenetic and molecular subtypes of myeloid malignancies, as well as outcome and prognosis of patients. However, the roles of miRNA deregulation in the pathogenesis of myeloid malignancies and how they cooperate with protein-coding gene variants in pathological mechanisms leading to the diseases have not yet been fully understood. In this review, we focus on recent insights into the role of miRNAs in the development and progression of myeloid malignant diseases and discuss the prospect that miRNAs may serve as a potential therapeutic target for leukemia.

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MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia

Cited by 37 publications

References 49 publications

MicroRNA‐26a‐5p inhibits breast cancer cell growth by suppressing RNF6 expression

MicroRNA‐26a‐5p inhibits breast cancer cell growth by suppressing RNF6 expression

Sirt1/Nrf2 signalling pathway prevents cognitive impairment in diabetic rats through anti‑oxidative stress induced by miRNA‑23b‑3p expression

MicroRNA, an Antisense RNA, in Sensing Myeloid Malignancies

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