MicroRNA-276 promotes egg-hatching synchrony by up-regulating
            <i>brm</i>
            in locusts

He, Jing; Chen, Qianquan; Wei, Yuanyuan; Jiang, Feng; Yang, Meiling; Hao, Shuai; Guo, Xiaojiao; Chen, Dahua; Kang, Le

doi:10.1073/pnas.1521098113

Cited by 85 publications

(80 citation statements)

References 54 publications

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“…miRNAs were usually negatively correlated with their targeted mRNAs, in spite of a few exceptions (He et al, 2016). The datasets of differentially expressed miRNAs and transcripts were integrated to identify the potential miRNA‐regulated target genes based on the following criteria: (a) miRNAs and mRNAs should be simultaneously and reversely changed in our analyses; (b) mRNAs should be predicted by miRNAs from software of RNAhybrid, Targetscan, and miRanda.…”

Section: Methodsmentioning

confidence: 99%

microRNA and mRNA profiles in nucleus accumbens underlying depression versus resilience in response to chronic stress

Song

Sun

et al. 2018

American J of Med Genetics Pt B

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Major depression in negative mood is presumably induced by chronic stress with lack of reward. However, most individuals who experience chronic stress demonstrate resilience. Molecular mechanisms underlying stress‐ induced depression versus resilience remain unknown, which are investigated in brain reward circuits. Mice were treated by chronic unpredictable mild stress (CUMS) for 4 weeks. The tests of sucrose preference, Y‐maze, and forced swimming were used to identify depression‐like emotion behavior or resilience. High‐throughput sequencing was used to analyze mRNA and miRNA quantity in the nucleus accumbens (NAc) harvested from the mice in the groups of control, CUMS‐induced depression (CUMS‐MDD), and CUMS‐resistance to identify molecular profiles of CUMS‐MDD versus CUMS‐resilience. In data analyses and comparison among three groups, 1.5‐fold ratio in reads per kilo‐base per million reads (RPKM) was set to judge involvements of mRNA and miRNA in CUMS, MDD, or resilience. The downregulations of serotonergic/dopaminergic synapses, MAPK/calcium signaling pathways, and morphine addiction as well as the upregulations of cAMP/PI3K‐Akt signaling pathways and amino acid metabolism are associated with CUMS‐MDD. The downregulations of chemokine signaling pathway, synaptic vesicle cycle, and nicotine addiction as well as the upregulations of calcium signaling pathway and tyrosine metabolism are associated with CUMS‐resilience. The impairments of serotonergic/dopaminergic synapses and PI3K‐Akt/MAPK signaling pathways in the NAc are associated with depression. The upregulation of these entities is associated with resilience. Consistent results from analyzing mRNA/miRNA and using different methods validate our finding and conclusion.

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Section: Methodsmentioning

confidence: 99%

microRNA and mRNA profiles in nucleus accumbens underlying depression versus resilience in response to chronic stress

Song

Sun

et al. 2018

American J of Med Genetics Pt B

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“…Epigenetic modulations encompass covalent chemical modifications of DNA (Razin & Riggs, 1980) and histone (Strahl & Allis, 2000) as well as the production of non-coding RNAs such as small interfering RNA (siRNA), microRNA (miRNA), Piwi-interacting RNA (piRNA), and transfer RNA (tRNA) fragments (Bartel, 2004;Flanagan & Wild, 2007;Mohammad et al, 2012;Chen et al, 2016;Sharma et al, 2016). Increasing evidence suggests that certain epigenetic changes, such as DNA methylation (Morgan et al, 1999;Rakyan et al, 2003;Carone et al, 2010;Franklin et al, 2010;Padmanabhan et al, 2013;Radford et al, 2014;Wei et al, 2014), histone modification (Katz et al, 2009;Greer et al, 2011;Seong et al, 2011;Ost et al, 2014;Siklenka et al, 2015), siRNA (Rechavi et al, 2011(Rechavi et al, , 2014Conine et al, 2013;HouriZe'evi et al, 2016), miRNAs (Gapp et al, 2014;Rodgers et al, 2015;He et al, 2016), piRNA (Ashe et al, 2012), and tRNA fragments Sharma et al, 2016) (Table 1) can be transmitted from parents to their offspring through the germline. Thus, the inheritance of epigenetic states may allow organisms to deliver either adaptive or non-adaptive/pathological information related to the ancestral environment to their offspring.…”

Section: Introductionmentioning

confidence: 99%

Lamarck rises from his grave: parental environment‐induced epigenetic inheritance in model organisms and humans

2017

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Organisms can change their physiological/behavioural traits to adapt and survive in changed environments. However, whether these acquired traits can be inherited across generations through non-genetic alterations has been a topic of debate for over a century. Emerging evidence indicates that both ancestral and parental experiences, including nutrition, environmental toxins, nurturing behaviour, and social stress, can have powerful effects on the physiological, metabolic and cellular functions in an organism. In certain circumstances, these effects can be transmitted across several generations through epigenetic (i.e. non-DNA sequence-based rather than mutational) modifications. In this review, we summarize recent evidence on epigenetic inheritance from parental environment-induced developmental and physiological alterations in nematodes, fruit flies, zebrafish, rodents, and humans. The epigenetic modifications demonstrated to be both susceptible to modulation by environmental cues and heritable, including DNA methylation, histone modification, and small non-coding RNAs, are also summarized. We particularly focus on evidence that parental environment-induced epigenetic alterations are transmitted through both the maternal and paternal germlines and exert sex-specific effects. The thought-provoking data presented here raise fundamental questions about the mechanisms responsible for these phenomena. In particular, the means that define the specificity of the response to parental experience in the gamete epigenome and that direct the establishment of the specific epigenetic change in the developing embryos, as well as in specific tissues in the descendants, remain obscure and require elucidation. More precise epigenetic assessment at both the genome-wide level and single-cell resolution as well as strategies for breeding at relatively sensitive periods of development and manipulation aimed at specific epigenetic modification are imperative for identifying parental environment-induced epigenetic marks across generations. Considering their diverse epigenetic architectures, the conservation and prevalence of the mechanisms underlying epigenetic inheritance in non-mammals require further investigation in mammals. Interpretation of the consequences arising from epigenetic inheritance on organisms and a better understanding of the underlying mechanisms will provide insight into how gene-environment interactions shape developmental processes and physiological functions, which in turn may have wide-ranging implications for human health, and understanding biological adaptation and evolution.

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“…It has also been reported that miRNAs can target the 5 ′ -UTR or coding regions (CDS) of mRNA, activating the transcription of target genes Yang et al 2014;He et al 2016). At present, 3119 miRNA precursors corresponding to 3824 mature miRNAs have been identified in 26 insects and deposited in miRBase (Ylla et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Multiple miRNAs jointly regulate the biosynthesis of ecdysteroid in the holometabolous insects, Chilo suppressalis

Sun

Xiao

et al. 2017

RNA

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The accurate rise and fall of active hormones is important for insect development. The ecdysteroids must be cleared in a timely manner. However, the mechanism of suppressing the ecdysteroid biosynthesis at the right time remains unclear. Here, we sequenced a small RNA library of Chilo suppressalis and identified 300 miRNAs in this notorious rice insect pest. Microarray analysis yielded 54 differentially expressed miRNAs during metamorphosis development. Target prediction and in vitro dualluciferase assays confirmed that seven miRNAs (two conserved and five novel miRNAs) jointly targeted three Halloween genes in the ecdysteroid biosynthesis pathway. Overexpression of these seven miRNAs reduced the titer of 20-hydroxyecdysone (20E), induced mortality, and retarded development, which could be rescued by treatment with 20E. Comparative analysis indicated that the miRNA regulation of metamorphosis development is a conserved process but that the miRNAs involved are highly divergent. In all, we present evidence that both conserved and lineage-specific miRNAs have crucial roles in regulating development in insects by controlling ecdysteroid biosynthesis, which is important for ensuring developmental convergence and evolutionary diversity.

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MicroRNA-276 promotes egg-hatching synchrony by up-regulating brm in locusts

Cited by 85 publications

References 54 publications

microRNA and mRNA profiles in nucleus accumbens underlying depression versus resilience in response to chronic stress

microRNA and mRNA profiles in nucleus accumbens underlying depression versus resilience in response to chronic stress

Lamarck rises from his grave: parental environment‐induced epigenetic inheritance in model organisms and humans

Multiple miRNAs jointly regulate the biosynthesis of ecdysteroid in the holometabolous insects, Chilo suppressalis

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