MicroRNA-30a Targets Notch1 to Alleviate Podocyte Injury in Lupus Nephritis

Role of microRNAs in Immune Regulation with Translational and Clinical Applications

“…miR-17-92 (rs4284505) [113], miR-146a [114], miR-365a-3p [115], miR-4689 [116] miR-21 [117], miR-124-3p, miR-146, miR-320b, miR-377-3p [118,119] miR-181a, miR-223 [120], miR-485-5p [121] miR-7 [122], miR-30a [123], miR-181d-5p [124], miR-590-3p [125] Antiphospholipid syndrome miR-326, miR-483-3p [126] miR-19b-3p, miR-20a-5p [127] miR-146a-5p [128] Systemic sclerosis, scleroderma miR-21 [129], miR-126 [130], miR-155-5p [131] miR-21 [132], miR-27a [133], miR-29a, miR-138 [134] miR-21-5p, miR-29a-3p, miR-143, miR-155 [135], miR-181b-5p, miR-210-3p, miR-223-3p [136] miR-27a [137], miR-214 [138] Sjögren's syndrome miR-181d-5p [139], miR-223-3p [140] miR-30 [141], miR-181b-5p, miR-322-5p, miR-424-5p, miR-503-5p [142], miR-513c-3p [143], miR-1290, let-7b-5p [144] miR-92a [145] miR-16, miR-125b [146], miR-142, miR-223 [147], let-7 [148] Autoimmune vasculitis miR-424-5p [149] miR-24-3p [150], miR-30a-5p, miR-33, miR-34 [151], miR-99a-5p, miR-106b-5p, miR-133a [152], miR-146a-5p [149], miR-148b-3p, miR-155-5p, miR-182-5p…”

“…According to recent results in a murine model, miR-590-3p mimics inhibited Th17 cells by suppressing autophagy, that may improve clinical symptoms of lupus [125]. Overexpression of miR-30a was found to ameliorate podocyte injury in LN through the suppression of Notch1 signaling pathway [123]. Similarly, up-regulation of miR-181d-5p also has therapeutic potential to improve LN by its impact on the mitogen-activated protein kinase 8 (MAPK8) enzyme [124].…”