MicroRNA-320 induces neurite outgrowth by targeting ARPP-1

White, Robin; Giffard, Rona G.

doi:10.1097/00001756-201207110-00003

Cited by 23 publications

(18 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…30 ARPP19 was predicted and validated as a direct target of miR-320 in neurite and miR-320a regulates tamoxifenresistant in breast cancer cells through targeting ARPP19. 29,36 We confirmed that miR-802 negatively regulated ARPP19 expression in GC cells by transfection with miR-802 mimics. Conversely, ARPP19 overexpression could partially reverse the inhibitory function of miR-802 in GC cell proliferation, migration, and invasion.…”

Section: Discussionsupporting

confidence: 56%

LncRNA IGFL2‐AS1 functions as a ceRNA in regulating ARPP19 through competitive binding to miR‐802 in gastric cancer

Liu

et al. 2020

Molecular Carcinogenesis

View full text Add to dashboard Cite

Gastric cancer (GC) is one of the most common malignancies of the digestive system worldwide. Multiple long noncoding RNAs (lncRNAs) participate in the regulation of GC development and metastasis. In this study, we aimed to elucidate the expression and function of lncRNA IGFL2‐AS1 in GC. We found that IGFL2‐AS1 was highly expressed in GC tissues and cell lines. Knockdown of IGFL2‐AS1 suppressed GC cell proliferation, migration, and invasion in vitro. Furthermore, we identified that IGFL2‐AS1 exerted its function as a molecular sponge of miR‐802. MiR‐802 was demonstrated to be a tumor suppressor, and overexpression of miR‐802 suppressed GC cell growth, migration, and invasion. Mechanistically, we revealed that the cAMP‐regulated phosphoprotein 19 (ARPP19) was a direct target of miR‐802 and could reverse the inhibitory function of miR‐802. Moreover, our results confirmed that knockdown of IGFL2‐AS1 inhibited GC tumor development in an in vivo GC tumor xenograft model. In summary, our data suggest that the IGFL2‐AS1/miR‐802/ARPP19 axis plays a critical role in the progression and metastasis of GC. Therapies targeting the IGFL2‐AS1/miR‐802/ARPP19 axis can potentially improve GC treatment.

show abstract

Section: Discussionsupporting

confidence: 56%

LncRNA IGFL2‐AS1 functions as a ceRNA in regulating ARPP19 through competitive binding to miR‐802 in gastric cancer

Liu

et al. 2020

Molecular Carcinogenesis

View full text Add to dashboard Cite

show abstract

“…Another exciting possibility with miRNAs is targeting plasticity and recovery after the acute phase of stroke. miRNAs have been shown to be critical in neuronal development, and there is potential that plasticity could be increased following stroke by, for example, encouraging neurite outgrowth using miRNAs such as miR-320 (186). Whereas pretreatment using miR-181a (130) and miR-29a (133) was effective in focal and global cerebral ischemia in rodents, testing treatment after the onset of ischemia is an essential step for the development of acute stroke treatment.…”

Section: Mirnas and Mitochondrial Protective Proteinsmentioning

confidence: 99%

The Use of microRNAs to Modulate Redox and Immune Response to Stroke

Ouyang

Stary

White

et al. 2015

Antioxidants & Redox Signaling

Self Cite

View full text Add to dashboard Cite

Significance: Cerebral ischemia is a major cause of death and disability throughout the world, yet therapeutic options remain limited. The interplay between the cellular redox state and the immune response plays a critical role in determining the extent of neural cell injury after ischemia and reperfusion. Excessive amounts of reactive oxygen species (ROS) generated by mitochondria and other sources act both as triggers and effectors of inflammation. This review will focus on the interplay between these two mechanisms. Recent Advances: MicroRNAs (miRNAs) are important post-transcriptional regulators that interact with multiple target messenger RNAs coordinately regulating target genes, including those involved in controlling mitochondrial function, redox state, and inflammatory pathways. This review will focus on the regulation of mitochondria, ROS, and inflammation by miRNAs in the chain of deleterious intra-and intercellular events that lead to brain cell death after cerebral ischemia. Critical Issues: Although pretreatment using miRNAs was effective in cerebral ischemia in rodents, testing treatment after the onset of ischemia is an essential next step in the development of acute stroke treatment. In addition, miRNA formulation and delivery into the CNS remain a challenge in the clinical translation of miRNA therapy. Future Directions: Future research should focus on post-treatment and potential clinical use of miRNAs. Antioxid. Redox Signal. 22,[187][188][189][190][191][192][193][194][195][196][197][198][199][200][201][202]

show abstract

“…miR-320 has been shown to be involved in growth, proliferation, and the cell cycle by targeting different genes in different cell lines (31,32). However, the functions and mechanisms of miR-320 in GC function during follicular development remain unclear.…”

mentioning

confidence: 99%

Transactivation of MicroRNA-320 by MicroRNA-383 Regulates Granulosa Cell Functions by Targeting E2F1 and SF-1 Proteins

Yin

Wang

Yao

et al. 2014

Journal of Biological Chemistry

129

View full text Add to dashboard Cite

Background: MicroRNAs are small noncoding RNAs associated with ovarian follicle development and female fertility. Results: miR-320 inhibited estradiol synthesis and proliferation of granulosa cells (GCs) through targeting E2F1 and SF-1 in vivo and in vitro. Conclusion: E2F1/SF-1 mediated miR-320-induced suppression of GC proliferation and of GC steroidogenesis. Significance: These will potentiate the usefulness of miRNA in the treatment of some steroid-related disorders.

show abstract

MicroRNA-320 induces neurite outgrowth by targeting ARPP-1

Cited by 23 publications

References 24 publications

LncRNA IGFL2‐AS1 functions as a ceRNA in regulating ARPP19 through competitive binding to miR‐802 in gastric cancer

LncRNA IGFL2‐AS1 functions as a ceRNA in regulating ARPP19 through competitive binding to miR‐802 in gastric cancer

The Use of microRNAs to Modulate Redox and Immune Response to Stroke

Transactivation of MicroRNA-320 by MicroRNA-383 Regulates Granulosa Cell Functions by Targeting E2F1 and SF-1 Proteins

Contact Info

Product

Resources

About