MicroRNA-331 inhibits development of gastric cancer through targeting musashi1

Liu, Yang; Song, Guang-Le; Zhai, Xiaoyu; Wang, Li; Liu, Qinlai; Zhou, Ming-Shun

doi:10.4251/wjgo.v11.i9.705

Cited by 11 publications

(14 citation statements)

References 31 publications

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“…miR-331 has also been reported to be a tumor suppressor in glioblastoma, which inhibited cell proliferation and clonogenic growth [31]. In gastric cancer, miR-331 was associated with poor prognosis and inhibited cell proliferation, metastasis, and tumor growth by targeting MSI1 [12]. The downregulation of miR-331 significantly affected the progression of ovarian cancer by targeting RCC2 [27].…”

Section: Discussionmentioning

confidence: 99%

“…miR-455-5p and miR-1255a were upregulated with poor overall survival, while the overexpression of their target genes was related to a good overall survival, which indicated the potential roles of mir-455-5p and miR-1255a in the therapy of breast cancer [10]. miR-331 is upregulated in breast cancer, and it has been demonstrated to be dysregulated in many other cancers, such as lung cancer, gastric cancer, and prostate cancer [11][12][13][14][15]. In gastric cancer, miR-331 was downregulated, which inhibited the cell proliferation, metastasis, and tumor growth of gastric cancer [12].…”

Section: Introductionmentioning

confidence: 94%

“…miR-331 is upregulated in breast cancer, and it has been demonstrated to be dysregulated in many other cancers, such as lung cancer, gastric cancer, and prostate cancer [11][12][13][14][15]. In gastric cancer, miR-331 was downregulated, which inhibited the cell proliferation, metastasis, and tumor growth of gastric cancer [12]. miR-331 was downregulated in non-small cell lung cancer (NSCLC), which significantly suppressed the migration and invasion of NSCLC cells through targeting ErbB2 and VAV2 [13].…”

Section: Introductionmentioning

confidence: 99%

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Overexpression of miR-331 Indicates Poor Prognosis and Promotes Progression of Breast Cancer

et al. 2020

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Background: With the increasing number of cases of breast cancer every year, the exploration of novel biomarkers has drawn attention. miR-331 has been demonstrated to play a role in various cancers, but its role in breast cancer is still unknown. Methods: In this study, we included 121 patients with breast cancer treated at Affiliated Hospital of Weifang Medical University. Breast cancer tissues and adjacent normal tissues were collected during the surgery. The expression of miR-331 in breast cancer tissues and cell lines was detected by qRT-PCR assay. Then, with the help of Kaplan-Meier survival and Cox regression analyses, the role of miR-331 in the prognosis of breast cancer was analyzed. Finally, the effect of miR-331 on cell proliferation, migration, and invasion was investigated with CCK-8 assay and transwell assay. Results: miR-331 was significantly upregulated in breast cancer tissues compared with normal tissues. The overexpression of miR-331 was associated with lymph node metastasis, TNM stage, and poor prognosis. From the results of Cox regression analyses, it was found that miR-331 served as an independent indicator in the prognosis of breast cancer. In addition, miR-331 was also found to be upregulated in breast cancer cells, which promoted cell proliferation, migration, and invasion of breast cancer. Conclusion: As shown from our data, miR-331 may be a potential prognostic biomarker in breast cancer. Moreover, the development and progression of breast cancer may involve miR-331. These findings suggest a novel therapeutic target for the treatment of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Overexpression of miR-331 Indicates Poor Prognosis and Promotes Progression of Breast Cancer

et al. 2020

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“…For instance, Yang et al pointed out that upregulation of MSI1 weakened the anti-cancer role of miR-331 in gastric cancer. 51 Gao et al stated that MSI1 was highly expressed in colon cancer tissues, and its downregulation inhibited the growth of colon cancer by targeting p21cip1. 52 Moreover, Araujo et al revealed that MSI1 could affect radioresistance via controlling DNA-protein kinase catalytic subunit in glioblastoma.…”

Section: Discussionmentioning

confidence: 99%

Exosomal circ_IFT80 Enhances Tumorigenesis and Suppresses Radiosensitivity in Colorectal Cancer by Regulating miR-296-5p/MSI1 Axis

Li¹,

Jiang²,

Zou³

et al. 2021

CMAR

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Background Exosomal circular RNAs (circRNAs) can act as biomarkers and play crucial roles in colorectal cancer (CRC) and radiosensitivity. The aim of this study was to explore the functions and regulatory mechanism of exosomal circRNA intraflagellar transport 80 (circ_IFT80) in tumorigenesis and radiosensitivity of CRC. Methods Exosomes were detected using transmission electron microscopy (TEM). Protein levels were determined by Western blot assay. The expression of circ_IFT80, microRNA-296-5p (miR-296-5p) and musashi1 (MSI1) was measured by quantitative real-time polymerase chain reaction (qRT-PCR). Cell cycle distribution, cell apoptosis, and cell proliferation were detected by flow cytometry and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, respectively. Colony formation assay was used to determine the radiosensitivity of cells. The interaction between miR-296-5p and circ_IFT80 or MSI1 was verified by dual-luciferase reporter assay. A xenograft tumor model was established to explore the role of exosomal circ_IFT80 in vivo. Results Circ_IFT80 was upregulated in exosomes derived from CRC patient serum and CRC cells. Exosomal circ_IFT80 or circ_IFT80 overexpression facilitated tumorigenesis by increasing cell proliferation and reducing apoptosis, and inhibited radiosensitivity via promoting colony formation and inhibiting apoptosis. Additionally, circ_IFT80 acted as a sponge of miR-296-5p, and miR-296-5p reversed the effects of circ_IFT80 on tumorigenesis and radiosensitivity. Moreover, MSI1 was a direct target of miR-296-5p. Furthermore, miR-296-5p overexpression inhibited tumorigenesis and promoted radiosensitivity by downregulating MSI1. Exosomal circ_IFT80 also accelerated tumor growth in vivo. Conclusion Exosomal circ_IFT80 promoted tumorigenesis and reduced radiosensitivity by regulating miR-296-5p/MSI1 axis, which might provide a novel avenue for treatment of CRC.

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“…Similarly, Gu et al found that the recurrence rate of esophageal adenocarcinoma patients with high-expressing serum miR-331-3p was lower, and miR-331-3p could be a potential biomarker for predicting tumor recurrence in patients with esophageal adenocarcinoma [25]. Yang et al found that miR-331-3p inhibits the development of gastric cancer by targeting MSI 1 and serve as an indicator of gastric cancer prediction and prognosis [26]. Novel targets of miR-331-3p for liver cancer were also revealed.…”

Section: Introductionmentioning

confidence: 96%

Potential targets and molecular mechanism of miR-331-3p in hepatocellular carcinoma identified by weighted gene coexpression network analysis

Chi

Geng

et al. 2020

Bioscience Reports

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumor. miR-331-3p has been reported relevant to the progression of HCC, but the molecular mechanism of its regulation is still unclear. In the study, we comprehensively studied the role of miR-331-3p in HCC through weighted gene coexpression network analysis (WGCNA) based on The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and Oncomine. WGCNA was applied to build gene co-expression networks to examine the correlation between gene sets and clinical characteristics, and to identify potential biomarkers. Five hundred one target genes of miR-331-3p were obtained by overlapping differentially expressed genes (DEGs) from the TCGA database and target genes predicted by miRWalk. The critical turquoise module and its eight key genes were screened by WGCNA. Enrichment analysis was implemented based on the genes in the turquoise module. Moreover, 48 genes with a high degree of connectivity were obtained by protein–protein interaction (PPI) analysis of the genes in the turquoise module. From overlapping genes analyzed by WGCNA and PPI, two hub genes were obtained, namely coatomer protein complex subunit zeta 1 (COPZ1) and elongation factor Tu GTP binding domain containing 2 (EFTUD2). In addition, the expression of both hub genes was also significantly higher in tumor tissues compared with normal tissues, as confirmed by analysis based on TCGA and Oncomine. Both hub genes were correlated with poor prognosis based on TCGA data. Receiver operating characteristic (ROC) curve validated that both hub genes exhibited excellent diagnostic efficiency for normal and tumor tissues.

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MicroRNA-331 inhibits development of gastric cancer through targeting musashi1

Cited by 11 publications

References 31 publications

Overexpression of miR-331 Indicates Poor Prognosis and Promotes Progression of Breast Cancer

Overexpression of miR-331 Indicates Poor Prognosis and Promotes Progression of Breast Cancer

Exosomal circ_IFT80 Enhances Tumorigenesis and Suppresses Radiosensitivity in Colorectal Cancer by Regulating miR-296-5p/MSI1 Axis

Potential targets and molecular mechanism of miR-331-3p in hepatocellular carcinoma identified by weighted gene coexpression network analysis

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