MicroRNA-342 targets Cofilin 1 to suppress the growth, migration and invasion of human breast cancer cells

Liu, Cong; Hua, Xin; Luo, Xiao; Wang, Yimin

doi:10.1016/j.abb.2020.108385

Cited by 18 publications

(18 citation statements)

References 23 publications

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“…Therefore, modulating the LIMK/CFL1 pathway offers potential for the personalised treatment of TNBC. Another study by Liu et al., [44] examined the role of the microRNA-342–3p in TNBC and its role as a tumour suppressor via modulation of cofilin-1. Cofilin-1 was found to be upregulated in breast cancer tissues and cell lines.…”

Section: The Role Of Cofilin-1 In Cancer and Metastasismentioning

confidence: 99%

The potential role of cofilin-1 in promoting triple negative breast cancer (TNBC) metastasis via the extracellular vesicles (EVs)

Howard

Goh

Gorzel

et al. 2022

Translational Oncology

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Highlights Triple negative breast cancer (TNBC) is a biological heterogeneous andn aggressive disease with a poor prognosis. Extracellular vesicles have been shown to play a role in mediating metastasis. Cofilin-1 has been detected in extracellular vesicles. Cofilin-1 is involved in promoting triple negative breast cancer metastasis.

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Section: The Role Of Cofilin-1 In Cancer and Metastasismentioning

confidence: 99%

The potential role of cofilin-1 in promoting triple negative breast cancer (TNBC) metastasis via the extracellular vesicles (EVs)

Howard

Goh

Gorzel

et al. 2022

Translational Oncology

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show abstract

“…33 Similarly, miR-342 has been shown to suppress breast cancer cell growth, migration and invasion. 17 MiR-342 has been demonstrated to act as ceRNA of lncRNAs, including LINC00634, RNA LINC00460 and lncRNA ZEB1-AS1. [34][35][36] We discovered that SNHG20 directly binds to miR-342 after performing a luciferase reporter gene assay.…”

Section: Discussionmentioning

confidence: 99%

“…MiR‐342 has been reported to target CBX2 and inhibit cell proliferation, metastasis and invasion of ovarian cancer cells 33 . Similarly, miR‐342 has been shown to suppress breast cancer cell growth, migration and invasion 17 . MiR‐342 has been demonstrated to act as ceRNA of lncRNAs, including LINC00634, RNA LINC00460 and lncRNA ZEB1‐AS1 34–36 .…”

Section: Discussionmentioning

confidence: 99%

“…16 MiR-342 also caused significant inhibition of the proliferation, colony formation, invasion and migration of breast cancer. 17 The DExD RNA helicases contains a conserved core consisting of nine conserved motifs that include the characteristic D-E-x-D motif, which confer ATP hydrolysis and RNA unwinding activities, establishing it as RNA helicase. 18 The DExD RNA helicases, belong to the superfamily 2 of helicases, which participate in almost all aspects of RNA metabolism.…”

Section: Introductionmentioning

confidence: 99%

“…For example, miR‐342 has been reported to significantly decrease cell proliferation, migration and colony formation in hepatocellular carcinoma 16 . MiR‐342 also caused significant inhibition of the proliferation, colony formation, invasion and migration of breast cancer 17 …”

Section: Introductionmentioning

confidence: 99%

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LncRNA SNHG20 promoted proliferation, invasion and inhibited cell apoptosis of lung adenocarcinoma via sponging miR‐342 and upregulating DDX49

Wang

Zhu

et al. 2020

Thoracic Cancer

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Background: There is increasing evidence that long non-coding RNA (lncRNA) small nucleolar RNA host gene 20 (SNHG20) plays an important role in cancer. However, the function of SNHG20 in lung adenocarcinoma is unclear. The aim of our study was to investigate the roles of SNHG20 in lung adenocarcinoma. Methods: Real-time quantitative polymerasechain reaction (RT-qPCR) was used to calculate the expression of SNHG20, miR-342 and DEAD-box helicase 49 (DDX49). Dual luciferase reporter gene assay was applied to verify whether miR-342 binding to SNHG20 and DDX49. The expression correlation between miR-342 and SNHG20 or DDX49 was assessed using Pearson's correlation analysis. Results: SNHG20 and DDX49 were overexpressed, while miR-342 was lowly expressed in lung adenocarcinoma tissues and cell lines. Knockdown of SNHG20 suppressed cell proliferation, invasion and enhanced cell apoptosis. SNHG20 was found to directly bind to miR-342 and regulate the expression of miR-342. MiR-342 directly targeted DDX49 and the expression of miR-342 had negative connection with DDX49 in lung adenocarcinoma tissues. Knockdown of DDX49 inhibited the progression of lung adenocarcinoma. DDX49 partially restored the functions of SNHG20 in A549 cells. Conclusions: SNHG20 regulated lung adenocarcinoma cell proliferation, invasion and promoted cell apoptosis via miR-342/DDX49 axis. Our findings demonstrate that SNHG20/miR-342/DDX49 axis plays an important role in lung adenocarcinoma, providing a novel insight into the treatment of lung adenocarcinoma.

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Differential effects of docosahexaenoic acid (DHA) and linoleic acid (LA) on miR-101 and miR-342 tumor suppressor microRNAs in Taxol-treated HER2-positive breast cancer cells

Aslan,

Maralbashi,

Shekari

et al. 2024

Clinical Nutrition ESPEN

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MicroRNA-342 targets Cofilin 1 to suppress the growth, migration and invasion of human breast cancer cells

Cited by 18 publications

References 23 publications

The potential role of cofilin-1 in promoting triple negative breast cancer (TNBC) metastasis via the extracellular vesicles (EVs)

The potential role of cofilin-1 in promoting triple negative breast cancer (TNBC) metastasis via the extracellular vesicles (EVs)

LncRNA SNHG20 promoted proliferation, invasion and inhibited cell apoptosis of lung adenocarcinoma via sponging miR‐342 and upregulating DDX49

Differential effects of docosahexaenoic acid (DHA) and linoleic acid (LA) on miR-101 and miR-342 tumor suppressor microRNAs in Taxol-treated HER2-positive breast cancer cells

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