MicroRNA-372 acts as a double-edged sword in human cancers

Tajik, Fatemeh; Alian, Fatemeh; Yousefi, Mohammad; Azadfallah, Ali; Hoseini, Aref; Mohammadi, Forogh; Karimi-Dehkordi, Maryam; Alizadeh-Fanalou, Shahin

doi:10.1016/j.heliyon.2023.e15991

Cited by 7 publications

(3 citation statements)

References 158 publications

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“…Future research on miRNA signatures in HNSC should focus on several promising directions to advance our understanding and clinical applications [ [65] , [66] , [67] ]. Firstly, there is a need to investigate novel miRNAs that have not been extensively studied in this context.…”

Section: Discussionmentioning

confidence: 99%

Survival associated miRNA signature in patients with head and neck carcinomas

Sathipati

2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Survival associated miRNA signature in patients with head and neck carcinomas

Sathipati

2023

Heliyon

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“…Breast cancer, excluding skin cancer, is the most frequent cancer diagnosis for women globally. The statistics show that approximately 13% of women worldwide will receive a diagnosis of invasive breast cancer ( 39 ). Breast cancer is the second leading cause of death for women, just behind lung cancer ( 40 , 41 ).…”

Section: Alterations Of Mirna In Breast Cancermentioning

confidence: 99%

Exploring the intricate relationship between miRNA dysregulation and breast cancer development: insights into the impact of environmental chemicals

Abolhasanzadeh,

Sarabandi,

Dehghan

et al. 2024

Front. Immunol.

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Breast cancer stands as the most prevalent form of cancer among women globally, influenced by a combination of genetic and environmental factors. Recent studies have investigated changes in microRNAs (miRNAs) during breast cancer progression and the potential impact of environmental chemicals on miRNA expression. This review aims to provide an updated overview of miRNA alterations in breast cancer and to explore their potential association with environmental chemicals. We will discuss the current knowledge on dysregulated miRNAs in breast cancer, including both upregulated and downregulated miRNAs. Additionally, we will review the influence of environmental chemicals, such as endocrine-disrupting compounds, heavy metals, and air pollutants, on miRNA expression and their potential contribution to breast cancer development. This review aims to advance our understanding of the complex molecular mechanisms underlying miRNA dysregulation in breast cancer by comprehensively examining miRNA alterations and their association with environmental chemicals. This knowledge is crucial for the development of targeted therapies and preventive measures. Furthermore, identifying specific miRNAs affected by environmental chemicals may allow the prediction of individual susceptibility to breast cancer and the design of personalized intervention strategies.

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“…MicroRNAs (miRNAs) are single-stranded, non-coding RNAs that function as negative regulators of the expression level of genes [15]. They play pivotal roles in diverse biological processes, encompassing embryonic development, cell proliferation, apoptosis, tissue remodeling, and notably, the process of carcinogenesis [16,17]. Genetic variations have been identified in both miRNA genes and their target genes, and these variations have been associated with a wide range of human diseases.…”

Section: Introductionmentioning

confidence: 99%

Impact of Mir196a-2 Genotypes on Colorectal Cancer Risk in Taiwan

Yueh

Wang

Chin

et al. 2023

IJMS

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We aimed to investigate the association between genotypes for mir146a and mir196a-2 and the risk of developing colorectal cancer (CRC). We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to determine the mir146a rs2910164 and mir196a-2 rs11614913 genotypes in 362 CRC patients and 362 controls. We also assessed the interactions between these genotypes and age, gender, smoking, alcohol consumption, and BMI status on CRC risk. Additionally, the serum expression level of mir196a-2 was quantified using quantitative reverse transcription-PCR. Our findings demonstrated that among the controls, the proportions of TT, CT, and CC genotypes of mir196a-2 rs11614913 were 32.3%, 48.1%, and 19.6%, respectively. As for the cases, the proportions were 24.6%, 45.0%, and 30.4%, respectively. Logistic regression analysis revealed that the CC genotype carriers had a 2.04-fold increased risk (95% confidence interval [CI] = 1.36–3.06, p = 0.0008). Furthermore, carriers of the CT + CC genotypes also exhibited a significant association with CRC risk (odds ratio [OR] = 1.46, 95% CI = 1.06–2.03, p = 0.0261). Moreover, carriers of the CC genotype had significantly higher serum levels of mir196a-2 compared to those with the TT genotype (p < 0.0001), indicating a genotype-phenotype correlation. No association was found regarding mir146a rs2910164. In conclusion, mir196a-2 rs2910164 genotypes, along with their associated expression, can serve as predictive markers for CRC risk.

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MicroRNA-372 acts as a double-edged sword in human cancers

Cited by 7 publications

References 158 publications

Survival associated miRNA signature in patients with head and neck carcinomas

Survival associated miRNA signature in patients with head and neck carcinomas

Exploring the intricate relationship between miRNA dysregulation and breast cancer development: insights into the impact of environmental chemicals

Impact of Mir196a-2 Genotypes on Colorectal Cancer Risk in Taiwan

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