MicroRNA-375 inhibits laryngeal squamous cell carcinoma progression via targeting CST1

Dai, Feng; Xie, Zuojun; Yang, Qiming; Zhong, Zhuanglong; Zhong, Chun; Qiu, Yongliang

doi:10.1016/j.bjorl.2022.06.005

Cited by 6 publications

(6 citation statements)

References 37 publications

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“…Limk1 [31] DLG2, Neurod2, NDE1, GBX2 CREB-1, BDNF [35] CDNF [36] miR-132-3p NR2A, Nr2B, GluR1 [37] NREP, SLC6A1, NOVA1, MAF, SLC6A3, LRRTM3, NRCAM cAMP [38] PTEN [39] miR-125b-5p 4E-BP1 [40] MAF, GDNF, ELAVL4, NCAN TNF-α [41] miR-375-3p PDK1, HuD [34] ELAVL4, PACSIN1, ELAVL3, NBEA HNF1B, KLF4, CST1 [42] brain: miR-134 5p [31], miR-132 3p [32], miR-125b 5p [33], and miR-375 3p [34], described in Table 3. Using targeted qPCR assays to measure these miRNAs from plasma samples, we observed significantly decreased levels of miR-134 (p = 0.008) and miR-132 (p = 0.027) following the KD (Figure 4b,d).…”

Section: Mir-134-5pmentioning

confidence: 99%

“…The levels of miR-125b, however, remained unaltered after the KD compared to before it (Figure 4a, p = 0.238), while the levels of miR-375 appeared significantly elevated (Figure 4c, p = 0.044). Limk1 [31] DLG2, Neurod2, NDE1, GBX2 CREB-1, BDNF [35] CDNF [36] miR-132-3p NR2A, Nr2B, GluR1 [37] NREP, SLC6A1, NOVA1, MAF, SLC6A3, LRRTM3, NRCAM cAMP [38] PTEN [39] miR-125b-5p 4E-BP1 [40] MAF, GDNF, ELAVL4, NCAN TNF-α [41] miR-375-3p PDK1, HuD [34] ELAVL4, PACSIN1, ELAVL3, NBEA HNF1B, KLF4, CST1 [42] 1 All predicted targets are based on in silico predictions by TargetScan [43].…”

Section: Mir-134-5pmentioning

confidence: 99%

“…miR-375 has been shown to inhibit BDNF-promoted neuronal outgrowth [34]. It also plays a role in inflammation through cystatin SN (CST1) [42].…”

Section: Kd-induced Changes To Bdnf-associated Mirnasmentioning

confidence: 99%

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Ketogenic Diet Induced Shifts in the Gut Microbiome Associate with Changes to Inflammatory Cytokines and Brain-Related miRNAs in Children with Autism Spectrum Disorder

Allan,

Yamamoto,

Kunihiro

et al. 2024

Nutrients

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In this interventional pilot study, we investigated the effects of a modified ketogenic diet (KD) on children with autism spectrum disorder (ASD). We previously observed improved behavioral symptoms in this cohort following the KD; this trial was registered with Clinicaltrials.gov (NCT02477904). This report details the alterations observed in the microbiota, inflammation markers, and microRNAs of seven children following a KD for a duration of 4 months. Our analysis included blood and stool samples, collected before and after the KD. After 4 months follow up, we found that the KD led to decreased plasma levels of proinflammatory cytokines (IL-12p70 and IL-1b) and brain-derived neurotrophic factor (BDNF). Additionally, we observed changes in the gut microbiome, increased expression of butyrate kinase in the gut, and altered levels of BDNF-associated miRNAs in the plasma. These cohort findings suggest that the KD may positively influence ASD sociability, as previously observed, by reducing inflammation, reversing gut microbial dysbiosis, and impacting the BDNF pathway related to brain activity.

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Section: Mir-134-5pmentioning

confidence: 99%

Section: Mir-134-5pmentioning

confidence: 99%

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Ketogenic Diet Induced Shifts in the Gut Microbiome Associate with Changes to Inflammatory Cytokines and Brain-Related miRNAs in Children with Autism Spectrum Disorder

Allan,

Yamamoto,

Kunihiro

et al. 2024

Nutrients

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“…Laryngeal squamous cell carcinoma (LSCC) is a common and aggressive tumor of HNSC and derives from the laryngeal mucosal epithelium, which has high mortality [ [2] , [3] , [4] ]. At present, the treatments extensively applied to LSCC include surgical resection, chemotherapy and radiotherapy [ 5 ]. Although these methods could be controlled with high probability, patients with LSCC are usually diagnosed in an advanced stage [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

The construction and validation of ECM-related prognosis model in laryngeal squamous cell carcinoma

Jiang,

Jiang

2023

Heliyon

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“…Alterations in the Wnt/β-catenin pathway contribute to the development/progression of several types of cancer, including NSCLC (17). Numerous studies have demonstrated the dysregulation of miRNAs in several types of cancer (18)(19)(20), and that aberrantly expressed miRNAs are related to dysregulation of the Wnt/β-catenin signaling (6). Numerous miRNAs inactivate the Wnt/β-catenin signaling pathway to affect the progression of NSCLC.…”

Section: Introductionmentioning

confidence: 99%

miR‑29a‑3p inhibits the malignant characteristics of non‑small cell lung cancer cells by reducing the activity of the Wnt/β‑catenin signaling pathway

Zhang

Han

et al. 2022

Oncol Lett

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MicroRNAs (miRNAs) can influence non-small cell lung cancer (NSCLC) in a tumor-suppressive and oncogenic manner. The present study aimed to investigate the effects and underlying mechanisms of miR-29a-3p in NSCLC. NSCLC cell lines (A549, H1299, and H460) and a normal lung epithelial cell line (BEAS-2B) were used. Additionally, a mouse lung tumor xenograft model was established using A549 cells and used to determine the effects of miR-29a-3p on NSCLC in vivo. Tumor volumes were measured every week. The expression of miR-29a-3p in cells and lung tissues were detected by RT-qPCR. Cell proliferation was detected using Cell Counting Kit-8 and EdU assays. Migration and invasion were assessed using wound healing and Transwell invasion assays, respectively. Ki-67 expression was detected using immunohistochemical staining. The expression levels of Wnt3a and β-catenin were determined using western blotting. miR-29a-3p expression was significantly downregulated in NSCLC cells and mice. In contrast to miR-29a-3p knockdown, miR-29a-3p overexpression decreased NSCLC cell proliferation, migration, and invasion as well as tumor growth in in the NSCLC mouse model. Moreover, miR-29a-3p overexpression decreased the protein expression levels of Wnt3a and β-catenin. The inhibitory effects of miR-29a-3p on NSCLC cells were reversed by LiCl (an activator of the Wnt signaling pathway). In conclusion, miR-29a-3p prevented NSCLC tumor growth and cell proliferation, migration, and invasion by inhibiting the Wnt/β-catenin signaling pathway. This finding offers novel insights into the prognosis and treatment of NSCLC.

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MicroRNA-375 inhibits laryngeal squamous cell carcinoma progression via targeting CST1

Cited by 6 publications

References 37 publications

Ketogenic Diet Induced Shifts in the Gut Microbiome Associate with Changes to Inflammatory Cytokines and Brain-Related miRNAs in Children with Autism Spectrum Disorder

Ketogenic Diet Induced Shifts in the Gut Microbiome Associate with Changes to Inflammatory Cytokines and Brain-Related miRNAs in Children with Autism Spectrum Disorder

The construction and validation of ECM-related prognosis model in laryngeal squamous cell carcinoma

miR‑29a‑3p inhibits the malignant characteristics of non‑small cell lung cancer cells by reducing the activity of the Wnt/β‑catenin signaling pathway

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