MicroRNA-421 promotes the proliferation and metastasis of gastric cancer cells by targeting claudin-11

Yang, Peng; Mei, Zhang; Liu, Xiting; Pu, Huayun

doi:10.3892/etm.2017.4798

Cited by 38 publications

(31 citation statements)

References 27 publications

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“…Increased miR-421 expression has also been reported in other malignancies, such as breast cancer and gastric cancer. 31 , 32 Moreover, the increased expression of miR-421 was first demonstrated to be associated with positive lymph-node metastasis and advanced TNM stage in NSCLC patients. These results indicate that miR-421 is a candidate oncogene and may be involved in tumor development in NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Upregulated expression of miR-421 is associated with poor prognosis in non-small-cell lung cancer

Cui

et al. 2018

CMAR

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BackgroundNon-small-cell lung cancer (NSCLC) represents the most frequent subtype of lung cancer. MicroRNAs (miRNAs) have attracted a lot of attention with regard to their clinical significance and crucial biological functions in various human cancers. This study aimed to investigate the prognostic significance of microRNA-421 (miR-421) and its correlation with tumor progression in NSCLC.Materials and methodsExpression levels of miR-421 in both serum and tissue samples were measured by quantitative real-time polymerase chain reaction (qRT-PCR). The prognostic value of miR-421 was evaluated using Kaplan–Meier survival analysis and Cox regression assay. To explore the functional role of miR-421 during NSCLC progression, cell experiments were carried out.ResultsExpression of serum and tissue miR-421 was upregulated in the NSCLC patients compared with the normal controls (all P<0.001), and the expression showed a significant correlation between the serum samples and tissues (R=0.475, P<0.001). The increased miR-421 expression was associated with positive lymph-node metastasis and advanced TNM stage (all P<0.05). Moreover, patients with high miR-421 expression had poor overall survival compared with those with low expression (log-rank P=0.007). The overexpression of miR-421 proved to be an independent prognostic factor for NSCLC (HR=1.991, 95% CI=1.046–3.791, P=0.036). According to the cell experiments, the proliferation, migration and invasion of NSCLC cells were suppressed by knockdown of miR-421.ConclusionOverexpression of miR-421 serves as a prognostic biomarker and may be involved in the promotion of tumor progression in NSCLC.

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Section: Discussionmentioning

confidence: 99%

Upregulated expression of miR-421 is associated with poor prognosis in non-small-cell lung cancer

Cui

et al. 2018

CMAR

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“…Additionally, expression of CLDN11 and CLDN23 is downregulated in gastric cancer89 and miR-421 was implicated in regulating CLDN11 expression to promote the proliferation, invasion and metastasis of gastric cancer cells90 (table 2). In contrast, CLDN23 positive expression was associated with poor prognostic outcomes of patients with gastric cancer and may therefore serve as an independent predictor of patient survival.…”

Section: Tj Proteins and The Gi Tractmentioning

confidence: 99%

Tight junction proteins in gastrointestinal and liver disease

Zeisel

Dhawan

Baumert

2018

Gut

244

179

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Over the past two decades a growing body of evidence has demonstrated an important role of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease. On one side, TJ proteins exert their functional role as integral proteins of TJs in forming barriers in the gut and the liver. Furthermore, TJ proteins can also be expressed outside TJs where they play important functional roles in signalling, trafficking and regulation of gene expression. A hallmark of TJ proteins in disease biology is their functional role in epithelial-to-mesenchymal transition. A causative role of TJ proteins has been established in the pathogenesis of colorectal cancer and gastric cancer. Among the best characterised roles of TJ proteins in liver disease biology is their function as cell entry receptors for HCV—one of the most common causes of hepatocellular carcinoma. At the same time TJ proteins are emerging as targets for novel therapeutic approaches for GI and liver disease. Here we review our current knowledge of the role of TJ proteins in the pathogenesis of GI and liver disease biology and discuss their potential as therapeutic targets.

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“…miR-375 was shown to play a role in epithelial-to-mesenchymal transition and in the recurrence of breast cancer [ 64 , 65 ]. miR-421 was found to induce cell migration and metastasis in neuroblastoma, osteosarcoma, and gastric cancer [ 66 , 67 , 68 ]. In the context of breast cancer, both were described as capable of inducing and inhibiting metastasis [ 69 , 70 ], emphasizing again the context-dependent role of regulatory elements in gene expression.…”

Section: Discussionmentioning

confidence: 99%

miRmapper: A Tool for Interpretation of miRNA–mRNA Interaction Networks

Silveira

Renaud

Simpson

et al. 2018

Genes

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It is estimated that 30% of all genes in the mammalian cells are regulated by microRNA (miRNAs). The most relevant miRNAs in a cellular context are not necessarily those with the greatest change in expression levels between healthy and diseased tissue. Differentially expressed (DE) miRNAs that modulate a large number of messenger RNA (mRNA) transcripts ultimately have a greater influence in determining phenotypic outcomes and are more important in a global biological context than miRNAs that modulate just a few mRNA transcripts. Here, we describe the development of a tool, “miRmapper”, which identifies the most dominant miRNAs in a miRNA–mRNA network and recognizes similarities between miRNAs based on commonly regulated mRNAs. Using a list of miRNA–target gene interactions and a list of DE transcripts, miRmapper provides several outputs: (1) an adjacency matrix that is used to calculate miRNA similarity utilizing the Jaccard distance; (2) a dendrogram and (3) an identity heatmap displaying miRNA clusters based on their effect on mRNA expression; (4) a miRNA impact table and (5) a barplot that provides a visual illustration of this impact. We tested this tool using nonmetastatic and metastatic bladder cancer cell lines and demonstrated that the most relevant miRNAs in a cellular context are not necessarily those with the greatest fold change. Additionally, by exploiting the Jaccard distance, we unraveled novel cooperative interactions between miRNAs from independent families in regulating common target mRNAs; i.e., five of the top 10 miRNAs act in synergy.

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MicroRNA-421 promotes the proliferation and metastasis of gastric cancer cells by targeting claudin-11

Cited by 38 publications

References 27 publications

Upregulated expression of miR-421 is associated with poor prognosis in non-small-cell lung cancer

Upregulated expression of miR-421 is associated with poor prognosis in non-small-cell lung cancer

Tight junction proteins in gastrointestinal and liver disease

miRmapper: A Tool for Interpretation of miRNA–mRNA Interaction Networks

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