2013
DOI: 10.1371/journal.pone.0064759
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MicroRNA-449a Is Downregulated in Non-Small Cell Lung Cancer and Inhibits Migration and Invasion by Targeting c-Met

Abstract: MicroRNA-449a is expressed at a low level in several tumors and cancer cell lines, and induces G1 arrest, apoptosis, and senescence. To identify the function of miR-449a in non-small cell lung cancer (NSCLC), we discussed the potential relevance of miR-449a to clinicopathological characteristics and prognosis in NSCLC. We also investigated the impact of miR-449a on migration and invasion in NSCLC cells. The expression of miR-449a in NSCLC tissues and cell lines was detected using RT-qPCR. In vitro, gain-of-fun… Show more

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Cited by 102 publications
(88 citation statements)
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“…Silencing or inactivation of MET has been demonstrated to be important for cell viability in vitro, as well as for cell motility and migration (11,30). In rhabdomyosarcoma, MET was demonstrated to be a direct target of miR-206 (15).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Silencing or inactivation of MET has been demonstrated to be important for cell viability in vitro, as well as for cell motility and migration (11,30). In rhabdomyosarcoma, MET was demonstrated to be a direct target of miR-206 (15).…”
Section: Discussionmentioning
confidence: 99%
“…Aberrant expression of miRNAs has been observed in lung cancer, including upregulation of miR-21, miR-17-92, miR-155 and miR-367 (6)(7)(8) and downregulation of let-7, miR-34b/c, miR-449a, miR-1 and miR-145 (8)(9)(10)(11)(12). This indicates that miRNAs can function as tumor suppressors and oncogenes in tumor development.…”
Section: Introductionmentioning
confidence: 99%
“…Together, these reports implicate Met as a potentially effective therapeutic target to reverse resistance to this important class of drugs in NSCLC. Moreover, the Met receptor promotes a complex biological program designated "invasion growth" that results from stimulation of cell motility, invasion and protection from apoptosis (Zhang et al, 2012;Luo et al, 2013). To better understand the up-stream pathways involved in NSCLC gefitinib resistance, we investigated the miRNA, miR130a, which can regulate Met expression.…”
Section: Discussionmentioning
confidence: 99%
“…There are numerous reports regarding the roles of miRNAs in NSCLC (10,12,21,22), however, little is known regarding the regulatory functions of miRNAs in SCLC.…”
Section: Discussionmentioning
confidence: 99%
“…Overexpression of miR-200 was shown to reduce the expression levels of NSCLC prognostic biomarkers in H1299 and BEAS-2B cells (11). miR-449a, which inhibited migration and invasion through targeting c-Met, was found to be downregulated in NSCLC tissues and cell lines (12). Reduced expression of miR-101 was associated with overexpression of EZH2 and exhibited tumor-suppressive functions in NSCLC (13).…”
Section: Introductionmentioning
confidence: 97%