microRNA-454 promotes liver tumor-initiating cell expansion by regulating SOCS6

Lei, Zhengqing; Tang, Xuewu; Si, Anfeng; Yang, Pinghua; Wang, Lihong; Luo, Tao; Guo, Guangmeng; Zhang, Qi; Cheng, Zhao

doi:10.1016/j.yexcr.2020.111955

Cited by 9 publications

(3 citation statements)

References 37 publications

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“…Likewise, the upregulation of miR-765 and miR-302d causes HCC proliferation and migration via suppressing INPP4B and TGFBR2 expression, respectively [ 37 , 38 ]. Migration and metastatic dissemination are also correlated with an upregulated miR-487a level via interacting with SPRED2 and PIK3R1 [ 39 ], while an increased miR-454 level exerts a significant oncogenic effect on tumor-initiating cells (T-ICs), leading to recurrent HCC, metastatic dissemination, and resistance to therapeutic modalities [ 40 ].…”

Section: The Emerging Role Of Mirnas In Hccmentioning

confidence: 99%

An Insight into the Arising Role of MicroRNAs in Hepatocellular Carcinoma: Future Diagnostic and Therapeutic Approaches

Koustas

Trifylli²,

Sarantis

et al. 2023

IJMS

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Hepatocellular carcinoma (HCC) constitutes a frequent highly malignant form of primary liver cancer and is the third cause of death attributable to malignancy. Despite the improvement in the therapeutic strategies with the exploration of novel pharmacological agents, the survival rate for HCC is still low. Shedding light on the multiplex genetic and epigenetic background of HCC, such as on the emerging role of microRNAs, is considered quite promising for the diagnosis and the prediction of this malignancy, as well as for combatting drug resistance. MicroRNAs (miRNAs) constitute small noncoding RNA sequences, which play a key role in the regulation of several signaling and metabolic pathways, as well as of pivotal cellular functions such as autophagy, apoptosis, and cell proliferation. It is also demonstrated that miRNAs are significantly implicated in carcinogenesis, either acting as tumor suppressors or oncomiRs, while aberrations in their expression levels are closely associated with tumor growth and progression, as well as with local invasion and metastatic dissemination. The arising role of miRNAs in HCC is in the spotlight of the current scientific research, aiming at the development of novel therapeutic perspectives. In this review, we will shed light on the emerging role of miRNAs in HCC.

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Section: The Emerging Role Of Mirnas In Hccmentioning

confidence: 99%

An Insight into the Arising Role of MicroRNAs in Hepatocellular Carcinoma: Future Diagnostic and Therapeutic Approaches

Koustas

Trifylli²,

Sarantis

et al. 2023

IJMS

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“…The gene for miR-454-3p, located on human chromosome 17 or chicken chromosome 15 (https://www.ncbi.nlm.nih.gov/gene/?term=mir-454), was found to modulate the tumorigenesis and progression of several malignancies [73][74][75]. Similar to gga-miR-130b-3p, gga-miR-454-3p suppresses IBDV replication through two mechanisms.…”

Section: Gga-mir-454-3pmentioning

confidence: 99%

“…On the other hand, gga-miR-454-3p increases the expression of IFN-β by targeting the suppressors of cytokine signaling 6 (SOCS6) in DF-1 cells, enhancing the innate immune response of the host cells to IBDV infection (Figure 1) [20]. Recently, it was reported that hsa-miR-454-3p directly targets SOCS6 in human liver cell lines and promotes the expansion of liver tumor-initiating cells [73], suggesting a wide interaction between miR-454-3p and SOCS6. However, unlike gga-miR-130b-3p, the expression level of gga-miR-454-3p in DF-1 cells is significantly reduced after IBDV infection [20], suggesting that gga-miR-454-3p can hardly exert an antiviral activity because IBDV infection inhibits the gga-miR-454-3p expression in host cells.…”

Section: Gga-mir-454-3pmentioning

confidence: 99%

Role of MicroRNAs in Host Defense against Infectious Bursal Disease Virus (IBDV) Infection: A Hidden Front Line

Zheng

2020

Viruses

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Infectious bursal disease (IBD) is an acute, highly contagious and immunosuppressive avian disease caused by infectious bursal disease virus (IBDV). In recent years, remarkable progress has been made in the understanding of the pathogenesis of IBDV infection and the host response, including apoptosis, autophagy and the inhibition of innate immunity. Not only a number of host proteins interacting with or targeted by viral proteins participate in these processes, but microRNAs (miRNAs) are also involved in the host response to IBDV infection. If an IBDV–host interaction at the protein level is taken imaginatively as the front line of the battle between invaders (pathogens) and defenders (host cells), their fight at the RNA level resembles the hidden front line. miRNAs are a class of non-coding single-stranded endogenous RNA molecules with a length of approximately 22 nucleotides (nt) that play important roles in regulating gene expression at the post-transcriptional level. Insights into the roles of viral proteins and miRNAs in host response will add to the understanding of the pathogenesis of IBDV infection. The interaction of viral proteins with cellular targets during IBDV infection were previously well-reviewed. This review focuses mainly on the current knowledge of the host response to IBDV infection at the RNA level, in particular, of the nine well-characterized miRNAs that affect cell apoptosis, the innate immune response and viral replication.

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LncRNA FLG-AS1 Mitigates Diabetic Retinopathy by Regulating Retinal Epithelial Cell Inflammation, Oxidative Stress, and Apoptosis via miR-380-3p/SOCS6 Axis

Luo

Xiao

et al. 2022

Inflammation

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microRNA-454 promotes liver tumor-initiating cell expansion by regulating SOCS6

Cited by 9 publications

References 37 publications

An Insight into the Arising Role of MicroRNAs in Hepatocellular Carcinoma: Future Diagnostic and Therapeutic Approaches

An Insight into the Arising Role of MicroRNAs in Hepatocellular Carcinoma: Future Diagnostic and Therapeutic Approaches

Role of MicroRNAs in Host Defense against Infectious Bursal Disease Virus (IBDV) Infection: A Hidden Front Line

LncRNA FLG-AS1 Mitigates Diabetic Retinopathy by Regulating Retinal Epithelial Cell Inflammation, Oxidative Stress, and Apoptosis via miR-380-3p/SOCS6 Axis

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