MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer

Ye, Lizhen; Fan, Tingting; Qin, Yao; Qiu, Cheng; Li, Lulu; Dai, Mengmeng; Zhou, Yaoyao; Chen, Yan; Jiang, Yuyang

doi:10.1080/15384101.2022.2154549

Cited by 3 publications

(2 citation statements)

References 66 publications

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“…H2AZ1 is the most highly expressed histone variant within the H2A family [14] and is overexpressed in various cancers, including prostate, bladder, non-small cell lung, breast, and colorectal cancers [15][16][17][18][19]. H2AZ1 overexpression in tumors is associated with a poor prognosis [20,21], suggesting its important role in tumor development and progression. H2AZ1 overexpression is more pronounced in metastatic cancer [22].…”

Section: Introductionmentioning

confidence: 99%

Identification and validation of an H2AZ1-based index model: a novel prognostic tool for hepatocellular carcinoma

Gao,

Lu,

Zhong

et al. 2024

Aging

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The H2A.Z variant histone 1 (H2AZ1) is aberrantly expressed in various tumors, correlating with an unfavorable prognosis. However, its role in hepatocellular carcinoma (HCC) remains unclear. We aimed to elucidate the pathways affected by H2AZ1 and identify promising therapeutic targets for HCC. Following bioinformatic analysis of gene expression and clinical data from The Cancer Genome Atlas and Gene Expression Omnibus database, we found 6,344 dysregulated genes related to H2AZ1 overexpression in HCC tissues (P < 0.05). We performed weighted gene co-expression network analysis to identify the gene module most related to H2AZ1. The H2AZ1-based index was further developed using Cox regression analysis, which revealed that the poor prognosis in the high H2AZ1-based index group could be attributed to elevated tumor stemness (P < 0.05). Moreover, the clinical model showed good prognostic potential (AUC > 0.7). We found that H2AZ1 knockdown led to reduced superoxide dismutase (SOD) activity, elevated malondialdehyde (MDA) levels, and increased apoptosis rate in tumor cells (P < 0.001). Thus, we developed an H2AZ1-based index model with the potential to predict the prognosis of patients with HCC. Our findings provide initial evidence that H2AZ1 overexpression plays a pivotal role in HCC initiation and progression.

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Section: Introductionmentioning

confidence: 99%

Identification and validation of an H2AZ1-based index model: a novel prognostic tool for hepatocellular carcinoma

Gao,

Lu,

Zhong

et al. 2024

Aging

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“…miRNA is a type of endogenous small noncoding RNA (sncRNA) comprising 18 25 nucleotides that regulates physiological functions including cellular growth, proliferation, and apoptosis ( 16 , 17 ). Several reports have revealed the significant involvement of miRNAs in various malignant processes of OC oncogenesis ( 18 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

lncRNA GAS5 suppression of the malignant phenotype of ovarian cancer via the miR-23a-WT1 axis

Zhou¹,

Jiang²,

Lin³

et al. 2023

Ann Transl Med

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Background Growth arrest-specific 5 (GAS5) is a long noncoding RNA (lncRNA) that regulates cell viability. GAS5 lncRNA has been shown to decrease colorectal and breast cancer carcinogenesis. Although the function and mechanisms related to lncRNA GAS5 in the development of ovarian cancer (OC) remains unclear. The goal of this study was to clarify the essential functions of lncRNA GAS5 in regulating OC progression and its underlying mechanism. Methods Relative levels of lncRNA GAS5 in OC and normal ovarian tissues were identified by quantitative real-time polymerase chain reaction (qRT-PCR). The regulatory effects of lncRNA GAS5 on the proliferation and apoptosis of SK-OV-3 cells were evaluated. Moreover, bioinformatics tools were used to predict a novel target [microRNA (miRNA)] of lncRNA GAS5. To explore the key functions of the lncRNA GAS5/miRNA-23a/WT1 regulatory loop in mediating OC progression, we performed functional experiments and a dual-luciferase reporter (DLR) gene assessment. Results Downregulation of lncRNA GAS5 was found in tissues of OC, which was positively correlated with a poor prognosis. In addition, SK-OV-3 cells with a lower expression of lncRNA GAS5 and accelerated cancer cell migration demonstrated a lower percentage of apoptosis in in vitro experiments. It was demonstrated that lncRNA GAS5 acts as a molecular sponge for miR-23a in OC cells. Additionally, WT1 was detected as a miR-23a target gene in OC cells, and through sponging miR-23a, lncRNA GAS5 positively regulated WT1 expression. Rescue tests demonstrated that enhancing the outputs of the miR-23a-WT1 axis reversed the impacts of lncRNA GAS5 silencing on cell proliferation and apoptosis in OC. Conclusions The lncRNA GAS5/miR-23a/WT1 cascade was found participate in the progression of OC. lncRNA GAS5 also decreases OC progression by upregulating WT1 and attenuating miR-23a, suggesting that it could be an advantageous therapeutic target for OC intervention.

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Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation

Ding

Chen

Zhao

et al. 2022

Biochemical Pharmacology

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MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer

Cited by 3 publications

References 66 publications

Identification and validation of an H2AZ1-based index model: a novel prognostic tool for hepatocellular carcinoma

Identification and validation of an H2AZ1-based index model: a novel prognostic tool for hepatocellular carcinoma

lncRNA GAS5 suppression of the malignant phenotype of ovarian cancer via the miR-23a-WT1 axis

Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation

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