MicroRNA‐493 is a prognostic factor in triple‐negative breast cancer

Yao, Ling; Liu, Yi-Rong; Cao, Zhigang; Li, Junjing; Huang, Yanni; Hu, Xin; Shao, Zhi‐Ming

doi:10.1111/cas.13644

Cited by 28 publications

(17 citation statements)

References 43 publications

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“…In fact, microRNA-493-5p was identified as most prominently upregulated in male breast cancer (28). MicroRNA-493 is a prognostic factor in TNBC and patients with high microRNA-493 expression have better disease-free survival than patients with low microRNA-493 expression (29). MicroRNA-493 and microRNA-19a can be used as diagnostic and prognostic markers of breast cancer (29,30).…”

Section: Discussionmentioning

confidence: 99%

“…MicroRNA-493 is a prognostic factor in TNBC and patients with high microRNA-493 expression have better disease-free survival than patients with low microRNA-493 expression (29). MicroRNA-493 and microRNA-19a can be used as diagnostic and prognostic markers of breast cancer (29,30). MicroRNA-493-5p, microRNA-130a, microRNA-130b-3p, microRNA-301, and microRNA-19a-3p suppress the migration and invasion of breast cancer cells (31)(32)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

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Effects of CORO2A on Cell Migration and Proliferation and Its Potential Regulatory Network in Breast Cancer

et al. 2020

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Coronin 2A (CORO2A) is a novel component of the N-CoR (nuclear receptor co-repressor) complex. Abnormal CORO2A expression is associated with carcinogenesis. We used databases from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), and analyzed CORO2A expression and gene regulation networks in breast cancer. Expression was analyzed using GEO and TCGA database and further validated in breast cancer samples collected in our clinic. The prognostic value of CORO2A was explored by using the Kaplan-Meier survival analysis and Cox proportional hazards regression analysis. LinkedOmics was used to identify coexpressed genes associated with CORO2A. After analyzing the intersection of coexpressed genes correlated with CORO2A and differentially expressed genes after CORO2A silencing, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of the intersecting genes were conducted by using FunRich software. Transwell assays were performed in breast cancer cells to determine the effect of CORO2A on cell migration. MTS, colony formation, and cell cycle distribution assays were performed in breast cancer cells to determine the effect of CORO2A on cell proliferation. Gene enrichment analysis was employed to explore the target networks of transcription factors and miRNAs. We found that CORO2A was upregulated and that the elevated expression of CORO2A was associated with poor overall survival (OS) and relapse-free survival (RFS) in TNBC patients. Further bioinformatics analysis of public sequencing data and our own RNA-Seq data revealed that CORO2A was probably involved in the epithelial-to-mesenchymal transition process and might have a significant effect on the migration of breast cancer cells, which might be mediated via pathways involving several miRNAs and MYC transcription factors. Functionally, the knockdown of CORO2A inhibited cell migration, decreased viability, and colony formation and induced cell cycle arrest in the G0/G1 phase in breast cancer cells. These results demonstrate that bioinformatics-based analysis efficiently reveals information about CORO2A expression and its potential regulatory networks in breast cancer, laying a foundation for further mechanistic Deng et al. Roles of CORO2A in Breast Cancer research on the role of CORO2A in carcinogenesis. Moreover, CORO2A promotes the migration and proliferation of breast cancer cells and may have an important function in breast cancer progression. CORO2A is a potential prognostic predictor for TNBC patients. Targeting CORO2A may provide promising therapy strategies for breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of CORO2A on Cell Migration and Proliferation and Its Potential Regulatory Network in Breast Cancer

et al. 2020

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“…Toyama et al found that miR-210 was highly expressed in Japanese TNBC patients, as a relatively independent factor to predict the OS for TNBC patients [183]. Yao et al explored the expression of miR-493 in breast cancer samples using tissue microarrays (TMAs), and showed that patients with high expression of miR-493 had better disease-free survival [42,184]. Son et al showed that miR-374a-5p was upregulated in TNBC patients.…”

Section: Prognostic Implications Of Mirnas In Tnbcmentioning

confidence: 99%

MicroRNAs Involved in Carcinogenesis, Prognosis, Therapeutic Resistance, and Applications in Human Triple-Negative Breast Cancer

Ding

Xiong

et al. 2019

Cells

125

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Triple-negative breast cancer (TNBC) is the most aggressive, prevalent, and distinct subtype of breast cancer characterized by high recurrence rates and poor clinical prognosis, devoid of both predictive markers and potential therapeutic targets. MicroRNAs (miRNA/miR) are a family of small, endogenous, non-coding, single-stranded regulatory RNAs that bind to the 3′-untranslated region (3′-UTR) complementary sequences and downregulate the translation of target mRNAs as post-transcriptional regulators. Dysregulation miRNAs are involved in broad spectrum cellular processes of TNBC, exerting their function as oncogenes or tumor suppressors depending on their cellular target involved in tumor initiation, promotion, malignant conversion, and metastasis. In this review, we emphasize on masses of miRNAs that act as oncogenes or tumor suppressors involved in epithelial–mesenchymal transition (EMT), maintenance of stemness, tumor invasion and metastasis, cell proliferation, and apoptosis. We also discuss miRNAs as the targets or as the regulators of dysregulation epigenetic modulation in the carcinogenesis process of TNBC. Furthermore, we show that miRNAs used as potential classification, prognostic, chemotherapy and radiotherapy resistance markers in TNBC. Finally, we present the perspective on miRNA therapeutics with mimics or antagonists, and focus on the challenges of miRNA therapy. This study offers an insight into the role of miRNA in pathology progression of TNBC.

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“…Despite these achievements, there is still much thought provoking mechanism urgent to explore between miRNAs and tumors. miR-493-3p, which has been extensively studied in multiple cancers, such as breast cancer [18], liver cancer [19], osteosarcoma [20], pancreatic cancer [21], melanoma [22]. Most studies showed that the lower expression of miR-493-3p acted as a cancer suppressor and associated with poor prognosis [23,24].…”

Section: Introductionmentioning

confidence: 99%

Identification of the Expression Signature and Potential Mechanisms of miR-493-3p in NSCLC using Bioinformatics Strategy: A Comprehensive Study from TCGA and GEO Datasets

zou

Zou

Luo

et al. 2020

Preprint

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Abstract Background Recent evidence highlights that miR-493-3p serve as crucial regulators of tumorigenesis. Nevertheless, the expression and clinical roles of miR-493-3p has been rarely reported in non-small cell lung cancer (NSCLC). Thus, this study was aim to investigate the expression status and potential mechanism of miR-493-3p in NSCLC progression. Methods We initially examined the expression of miR-493-3p in NSCLC through The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) microarrays. The overlap of the conjecture miR-493-3p target genes and down-regulated genes in NSCLC from TCGA were identified as the possible miR-493-3p target genes. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses and protein-protein interaction (PPI) network were constructed to explore the biological function and hub genes of miR-493-3p targets. The expression pattern and prognosis value of key hub genes were examined by Genotype-Tissue Expression (GTEx) database, The Human Protein Atlas and Kaplan- Meier Plotter database. Results miR-493-3p was significantly increased in NSCLC tissues and connected with tumor stage in TCGA and GEO database. A total of 46 genes were identified as miR-493-3p targets, and those involved in various key pathways by GO and KEGG analysis. Furthermore, PH domain and leucine-rich repeat protein phosphatase 2 (PHLPP2) was indicated of miR-493-3p key targets, which low-expressed in NSCLC and predicted better overall survival. Conclusions Our study emphasized that up-regulated miR-493-3p may target PHLLP2 and predicate worse prognosis of NSCLC patients.

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MicroRNA‐493 is a prognostic factor in triple‐negative breast cancer

Cited by 28 publications

References 43 publications

Effects of CORO2A on Cell Migration and Proliferation and Its Potential Regulatory Network in Breast Cancer

Effects of CORO2A on Cell Migration and Proliferation and Its Potential Regulatory Network in Breast Cancer

MicroRNAs Involved in Carcinogenesis, Prognosis, Therapeutic Resistance, and Applications in Human Triple-Negative Breast Cancer

Identification of the Expression Signature and Potential Mechanisms of miR-493-3p in NSCLC using Bioinformatics Strategy: A Comprehensive Study from TCGA and GEO Datasets

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