MicroRNA-494-3p Promotes Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Targeting Sox7

He, Huiping; Liao, Xuan; Yang, Qingmei; Liu, Yuan; Peng, Yan; Zhong, Hao‐Jie; Yang, Jun; Zhang, Huiqing; Zhong, Yu; Zuo, Yufang; Guan, Chengnong; Xu, Zhonghua

doi:10.1177/1533033818809993

Cited by 36 publications

(29 citation statements)

References 47 publications

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“…MiRNAs play a significant role in different biological stages of NPC, such as cell viability, migration, invasion, epithelial‐mesenchymal transition, and apoptosis . For example, synthetic miR‐494‐3p mimics enhanced NPC cell proliferation, migration, and invasion via suppressing Sox7 expression . Although many studies have demonstrated the important influence of miR‐103/TIMP‐3 in human cancer pathogenesis, the interaction of miR‐103 and TIMP‐3 in NPC has not been examined.…”

Section: Discussionmentioning

confidence: 99%

“…25,26 For example, synthetic miR-494-3p mimics enhanced NPC cell proliferation, migration, and invasion via suppressing Sox7 expression. 27 Although many studies have demonstrated the important influence of miR-103/TIMP-3 in human cancer pathogenesis, 22 the interaction of miR-103 and TIMP-3 in NPC has not been examined. The higher miR-103 expression was observed in human NPC tissues and cells, and patients with low miR-103 expression had a clearly longer 5-year survival time, which was largely consistent with previous findings of the miR-103 effect.…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA‐103 promotes nasopharyngeal carcinoma through targeting TIMP‐3 and the Wnt/β‐catenin pathway

Zhao

Wang

2019

The Laryngoscope

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Objectives/Hypothesis To verify how microRNA‐103 (miR‐103) is involved in nasopharyngeal carcinoma (NPC) development. Study Design Research on the relationship between miR‐103 and NPC. Methods Tissue inhibitor of metalloproteinases‐3 (TIMP‐3) was identified as the theoretical target gene of miR‐103, and its regulatory mechanism in NPC was explored by quantitative reverse transcription polymerase chain reaction, Western blot, MTT, transwell, and luciferase reporter assays. Results MiR‐103 was upregulated whereas TIMP‐3 was markedly decreased in NPC tissue samples. Ectopic expression of miR‐103 promoted NPC cell viability, migration, and invasion. In vitro assay showed that TIMP‐3 recovered miR‐103–mediated promotion of NPC cell viability, migration, and invasion. The expression of Wnt/β‐catenin pathway markers (β‐catenin and cyclin D1) were enhanced after miR‐103 overexpression. Conclusions MiR‐103 might play a key role in NPC carcinogenesis by targeting TIMP‐3 and affecting the Wnt/β‐catenin pathway. Level of Evidence NA Laryngoscope, 130:E75–E82, 2020

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

MicroRNA‐103 promotes nasopharyngeal carcinoma through targeting TIMP‐3 and the Wnt/β‐catenin pathway

Zhao

Wang

2019

The Laryngoscope

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“…It is highly malignant and is accompanied by local invasion and metastasis at an early stage. 1 A unique feature of NPC is its strikingly unusual ethnic and geographic distribution, as the incidence is significantly different in the USA in the white (0.8/ 100,000 persons per year) and Asian communities (7.6-10.7/100.000 persons per year). [2][3][4][5][6] It has been reported that the survival rates of early stage NPC patients reached 75-90%; however, they are less than 50% at the stage of metastasis.…”

Section: Introductionmentioning

confidence: 99%

<p>Identification of Apolipoprotein E as a Potential Diagnostic Biomarker of Nasopharyngeal Carcinoma</p>

Xue

Huang

et al. 2020

CMAR

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Purpose: Apo-E, a secreted protein, is closely related to the migration and invasion of tumor cells. In this study, we aimed to analyze the expression of Apo-E in nasopharyngeal carcinoma (NPC) patients and cell lines, as well as its effects on NPC cell behavior. Patients and Methods: Our study included 35 patients with NPC from Zhongnan Hospital. Expression levels of Apo-E in patients with NPC were examined by quantitative reverse transcription-polymerase chain reaction, Western blot, and immunohistochemical (IHC) staining. Receiver operating characteristic (ROC) curves were analyzed using the SPSS 22 software to estimate the sensitivity and specificity of the Apo-E protein in diagnosing NPC. Additionally, the level of Apo-E in NPC cell lines (NP69, 6-10B, and 5-8F) was investigated by Western blotting and IHC. Results: Levels of Apo-E were higher in NPC patients than in controls. Moreover, ROC analysis revealed that increased Apo-E in the serum of NPC patients may act as a potential biomarker for NPC diagnosis (Area under the curve 0.917). Furthermore, similar results were also identified in NPC cancer cell lines. RNA interference technology was used to overexpress the endogenous Apo-E in the NPC cell line 6-10B. Wound healing and transwell assays indicated that the overexpression of Apo-E increased the number of cell colonies and migration ability, respectively. Conclusion: In this study, we found that Apo-E was elevated in NPC patients and may act as a potential biomarker for NPC diagnosis. In addition, Apo-E was upregulated in NPC cell lines and promoted cell growth, migration, and invasion.

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“…Despite the progress achieved in many therapeutic strategies, the underlying mechanism of NPC still remains largely unknown and the prognosis of cancer patients is also relatively poor [6,7].…”

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confidence: 99%

SOCS2 affects the proliferation, migration, and invasion of nasopharyngeal carcinoma cells via regulating EphA1

Dai

Zhang

2020

neo

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Although the incidence of nasopharyngeal carcinoma (NPC) is relatively low, the mortality is very high and the patients have a poor prognosis. Thus, it is urgent to find a novel biomarker and a new therapeutic strategy. Suppressor of cytokine signaling-2 (SOCS2) was reported to be associated with various malignancies. However, the exact role of SOCS2 in NPC still remains largely unsure.In the present study, we showed that the expression of SOCS2 was significantly upregulated in NPC patients and cells. And the high expression of SOCS2 predicted a worse outcome in NPC patients.Moreover, the in vivo experiments indicated that knockout of SOCS2 inhibits the proliferation, migration and invasion of NPC cells. Besides, we found a positive relationship between SOCS2 and EphA1 in NPC tissues. The rescue experiments indicated that SOCS2 affected the malignancy of NPC cells by regulating the expression of EphA1. Altogether, our data uncovered the ontogenetic role of SOCS2 dysregulation during the tumorigenesis of NPC. SOCS2 might serve as a biomarker during the diagnosis and treatment of NPC. And targeting SOCS2 might provide a novel treatment strategy for NPC patients.

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MicroRNA-494-3p Promotes Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Targeting Sox7

Cited by 36 publications

References 47 publications

MicroRNA‐103 promotes nasopharyngeal carcinoma through targeting TIMP‐3 and the Wnt/β‐catenin pathway

MicroRNA‐103 promotes nasopharyngeal carcinoma through targeting TIMP‐3 and the Wnt/β‐catenin pathway

<p>Identification of Apolipoprotein E as a Potential Diagnostic Biomarker of Nasopharyngeal Carcinoma</p>

SOCS2 affects the proliferation, migration, and invasion of nasopharyngeal carcinoma cells via regulating EphA1

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