MicroRNA‐590 Promotes Cervical Cancer Cell Growth and Invasion by Targeting CHL1

Chu, Yanxia; Ouyang, Yunwei; Wang, Fei; Zheng, Ai; Bai, Liping; Han, Ling; Chen, Yali; Wang, Hui

doi:10.1002/jcb.24726

Cited by 79 publications

(68 citation statements)

References 21 publications

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“…It has been reported that miR-590-5p is up-regulated in human cervical cancer. Cell growth, cell cycle and invasion are induced by the over-expression of miR-590-5p in HeLa and C33A cell lines (Chu et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus E6 and E7 oncoproteins affect the expression of cancer-related microRNAs: additional evidence in HPV-induced tumorigenesis

Chiantore

Mangino

Iuliano

et al. 2016

J Cancer Res Clin Oncol

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Section: Discussionmentioning

confidence: 99%

Human papillomavirus E6 and E7 oncoproteins affect the expression of cancer-related microRNAs: additional evidence in HPV-induced tumorigenesis

Chiantore

Mangino

Iuliano

et al. 2016

J Cancer Res Clin Oncol

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“…Increased expression of miR-590 has been found in hepatocellular carcinoma [16] and cervical cancer [17]. However, the relationship between miR-590 and T-ALL has never been reported before.…”

Section: Discussionmentioning

confidence: 99%

miR-590 promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia by inhibiting RB1

Miao

Zhang

et al. 2016

Oncotarget

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MicroRNAs play important roles in the pathogenesis of cancers by inhibiting gene expression at posttranscriptional level. Here, we identified that miR-590 and its predicted target gene RB1 are differentially expressed in T-cell acute lymphoblastic leukaemia (T-ALL). The correlation between miR-590 and RB1 was further confirmed in 395 T-ALL patients. In T-ALL cell lines, miR-590 promoted the cell proliferation by increasing G1/S transition. Moreover, migration and invasion assay showed that miR-590 promotes the migration and invasion of T-ALL cells by increasing E-cadherin and inhibiting MMP-9. Luciferase assays confirmed that miR-590 directly binds to the 3′untranslated region of RB1, and western blotting showed that miR-590 suppresses the expression of RB1 at the protein levels. This study indicated that miR-590 inhibits RB1 and promotes proliferation and invasion of T-ALL cells. Thus, miR-590 may represent a potential therapeutic target for T-ALL intervention.

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“…The invasion ability was investigated by transwell assay29. 200 μL HeLa cells (2 × 10 5 /mL in serum free RPMI-1640) transfected with nano-lipoplexes (PLP/PAAV 2 , FLP/PAAV 2 , PLP/PEDF and FLP/PEDF) were placed on the top chamber of each transwell (8 μm pore size, Corning, America) coated with 50 μL diluted Matrigel (volume ratio to RPMI-1640 serum-free was 1:3).…”

Section: Methodsmentioning

confidence: 99%

Promising Nanocarriers for PEDF Gene Targeting Delivery to Cervical Cancer Cells Mediated by the Over-expressing FRα

Yang

Liu

et al. 2016

Sci Rep

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Cervical cancer presents extremely low PEDF expression which is associated with tumor progression and poor prognosis. In this study, folate receptor α (FRα)-targeted nano-liposomes (FLP) were designed to enhance the anti-tumor effect by targeting delivery of exogenous PEDF gene to cervical cancer cells. The targeting molecule F-PEG-Chol was firstly synthesized by a novel simpler method. FLP encapsulating PEDF gene (FLP/PEDF) with a typical lipid-membrane structure were prepared by a film dispersion method. The transfection experiment found FLP could effectively transfect human cervical cancer cells (HeLa cells). FLP/PEDF significantly inhibited the growth of HeLa cells and human umbilical vein endothelial cells (HUVEC cells) and suppressed adhension, invasion and migration of HeLa cells in vitro. In the abdominal metastatic tumor model of cervical cancer, FLP/PEDF administered by intraperitoneal injection exhibited a superior anti-tumor effect probably due to the up-regulated PEDF. FLP/PEDF could not only sharply reduce the microvessel density but also dramatically inhibit proliferation and markedly induce apoptosis of tumor cells in vivo. Moreover, the preliminary safety investigation revealed that FLP/PEDF had no obvious toxicity. These results clearly showed that FLP were desired carriers for PEDF gene and FLP/PEDF might represent a potential novel strategy for gene therapy of cervical cancer.

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MicroRNA‐590 Promotes Cervical Cancer Cell Growth and Invasion by Targeting CHL1

Cited by 79 publications

References 21 publications

Human papillomavirus E6 and E7 oncoproteins affect the expression of cancer-related microRNAs: additional evidence in HPV-induced tumorigenesis

Human papillomavirus E6 and E7 oncoproteins affect the expression of cancer-related microRNAs: additional evidence in HPV-induced tumorigenesis

miR-590 promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia by inhibiting RB1

Promising Nanocarriers for PEDF Gene Targeting Delivery to Cervical Cancer Cells Mediated by the Over-expressing FRα

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