microRNA-671-5p reduces tumorigenicity of ovarian cancer via suppressing HDAC5 and HIF-1α expression

Peng, Dongxian; Wu, Tingting; Wang, Junxia; Huang, Jie; Zheng, Ling; Wang, Pingping; Li, Junpeng; Wu, Lin; Luo, Min

doi:10.1016/j.cbi.2021.109780

Cited by 11 publications

(5 citation statements)

References 37 publications

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“…For instance, in pancreatic cancer models, down-regulation of miR-671 has been associated with enhancement of tumor growth ( Shen et al, 2021 ). Similar results have been obtained in xenograft models of ovarian cancer ( Peng et al, 2022 ). On the other hand, studies in animal models of colorectal cancer have reported opposite results ( Yang et al, 2022b ).…”

Section: Cell Line Studiessupporting

confidence: 86%

A review on the role of miR-671 in human disorders

Ghafouri‐Fard

Askari

Hussen

et al. 2022

Front. Mol. Biosci.

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miR-671 is encoded by a gene on 7q36.1 and contributes to the pathogenesis of a variety of disorders, including diverse types of cancers, atherosclerosis, ischemic stroke, liver fibrosis, osteoarthritis, Parkinson’s disease, rheumatoid arthritis, acute myocardial infarction and Crohn’s disease. In the context of cancer, different studies have revealed opposite roles for this miRNA. In brief, it has been shown to be down-regulated in pancreatic ductal carcinoma, ovarian cancer, gastric cancer, osteosarcoma, esophageal squamous cell carcinoma and myelodysplastic syndromes. Yet, miR-671 has been up-regulated in glioma, colorectal cancer, prostate cancer and hepatocellular carcinoma. Studies in breast, lung and renal cell carcinoma have reported inconsistent results. The current review aims at summarization of the role of miR-671 in these disorders focusing on its target mRNA in each context and dysregulated signaling pathways. We also provide a summary of the role of this miRNA as a prognostic factor in malignancies.

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Section: Cell Line Studiessupporting

confidence: 86%

A review on the role of miR-671 in human disorders

Ghafouri‐Fard

Askari

Hussen

et al. 2022

Front. Mol. Biosci.

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“…Interestingly, the presence of nuclear HDAC-5 immunohistochemical positivity was associated with the presence of lymph nodes metastasis. Similarly, Peng et al observed that the suppression of miR-671-5p or promotion of HDAC5 expression encouraged ovarian carcinoma tumor growth in animal models [27].…”

Section: Discussionmentioning

confidence: 92%

Clinical Significance of the Immunohistochemical Expression of Histone Deacetylases (HDACs)-2, -4 and -5 in Ovarian Adenocarcinomas

Levidou,

Arsenakis,

Bolovis

et al. 2024

Preprint

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Background: Histone deacetylases (HDACs) are implicated in carcinogenesis, and HDAC inhibitors (HDACis) are explored as a therapeutic tool in several tumors. The aim of this study was to evaluate the clinical significance of HDAC -2, -4, and -5 expression in epithelial ovarian carcinoma (EOC). Methods: HDAC-2, -4, and -5 immunohistochemical expression was examined in 92 EOC tissue specimens and was correlated with clinicopathological characteristics. Results: HDAC-2 was the most frequently (94.4%) expressed isoform, being marginally higher in serous tumors compared with other types (p=0,08). HDAC-5 was the less frequently expressed (28.1%), being positively associated with HDAC-4. HDAC-4 positivity was associated with lower FIGO-stage (p=0,045) and T-category (p=0.,043) and the absence of lymph node (p=0,05) or distant metastasis (p=0,09) in serous carcinomas. HDAC-2 positivity was correlated with absence of lymph node metastasis in serous tumors (p=0,045). On the contrary, HDAC-5 nuclear positivity was correlated with lymph node metastasis in the entire cohort (p=0,048). HDAC-4 positivity was marginally associated with favorable prognosis in serous carcinomas in univariate survival analysis (p=0,086), a correlation which was not significant in multivariate analysis. Conclusion: These findings suggest a differential expression of HDAC-2, -4 and -5, providing evidence for a potential role in the pathobiology of EOC.

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“…In non-serous ovarian cancer, HDAC 9 can induce β-catenin translocation to the cytoplasm and decrease the expression of its down stream gene through regulating the acetylation of β-catenin [72]. In addition, up-regulated HDAC5 can promote cell proliferation, migration and invasion by interacting with hy poxia-inducible factor-1α (HIF-1α) and elevating the protein level of HIF-1α [102]. (Figure 1).…”

Section: The Underlying Mechanism Of Histone Deacetylases In Regulati...mentioning

confidence: 99%

The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis

Xu,

Yan,

Wang

et al. 2023

IJMS

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Ovarian cancer is the most lethal gynecologic malignancy, and metastasis is the major cause of death in patients with ovarian cancer, which is regulated by the coordinated interplay of genetic and epigenetic mechanisms. Histone deacetylases (HDACs) are enzymes that can catalyze the deacetylation of histone and some non-histone proteins and that are involved in the regulation of a variety of biological processes via the regulation of gene transcription and the functions of non-histone proteins such as transcription factors and enzymes. Aberrant expressions of HDACs are common in ovarian cancer. Many studies have found that HDACs are involved in regulating a variety of events associated with ovarian cancer metastasis, including cell migration, invasion, and the epithelial–mesenchymal transformation. Herein, we provide a brief overview of ovarian cancer metastasis and the dysregulated expression of HDACs in ovarian cancer. In addition, we discuss the roles of HDACs in the regulation of ovarian cancer metastasis. Finally, we discuss the development of compounds that target HDACs and highlight their importance in the future of ovarian cancer therapy.

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microRNA-671-5p reduces tumorigenicity of ovarian cancer via suppressing HDAC5 and HIF-1α expression

Cited by 11 publications

References 37 publications

A review on the role of miR-671 in human disorders

A review on the role of miR-671 in human disorders

Clinical Significance of the Immunohistochemical Expression of Histone Deacetylases (HDACs)-2, -4 and -5 in Ovarian Adenocarcinomas

The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis

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