MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK signaling

Dou, Zhimin; Lu, Fei; Hu, Jun; Wang, Haiping; Li, Bin; Li, Xun

doi:10.1515/hsz-2022-0156

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…MiR-6838-5p was down-regulated in a variety of cancer types, including breast cancer [ 20 ], stomach cancer [ 21 ] and Osteosarcoma [ 22 ], as demonstrated in the prior work. It has been discovered that miR-6838-5p inhibits the self-renewal and metastasis of human HCC stem cells via deactivating ERK signaling and downregulating CBX4 expression [ 23 ]. In line with other studies, we discovered miR-6838-5p repressed the expression of PTPN4 and reduced HCC growth, migration and invasion.…”

Section: Discussionmentioning

confidence: 99%

LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4

Zhao,

Zhu,

Xiao

et al. 2024

Aging

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Background: Long noncoding RNAs (LncRNAs) have been demonstrated to have significant roles in the carcinogenesis of hepatocellular carcinoma (HCC). In this work, we sought to determine LncRNA SH3BP5-AS1’s function and mechanism in the emergence of HCC. Results: First, we discovered that the advanced tumor stage was strongly correlated with high levels of LncRNA SH3BP5-AS1 expression in HCC. MiR-6838-5p expression was down-regulated and inversely correlated with SH3BP5-AS1 expression. Additionally, overexpression of SH3BP5-AS1 boosted cell invasion, migration, and proliferation. The oncogenic effects of the inhibitor of miR-6838-5p were eliminated when PTPN4 was suppressed, following the identification of PTPN4 as a direct target of miR-6838-5p. In addition, SH3BP5-AS1 promoted cellular glycolysis via miR-6838-5p sponging and PTPN4 activation. Lastly, by directly interacting to the promoter of SH3BP5-AS1, HIF-1α could control the transcription of the gene. Conclusions: Our research suggests that SH3BP5-AS1 controls miR-6838-5p/PTPN4 in order to act as a new carcinogenic LncRNA during the growth of HCC cells. Methods: The expression levels of SH3BP5-AS1, miR-6838-5p and PTPN4 were detected by qRT-PCR and Western blot. The effects of LncRNA SH3BP5-AS1/miR-6838-5p/PTPN4 on the proliferation, metastasis and glycolysis of HCC cells were clarified by experimental cellular functionality assays, cell derived xenograft and Glycolysis assay.

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Section: Discussionmentioning

confidence: 99%

LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4

Zhao,

Zhu,

Xiao

et al. 2024

Aging

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“…The lncRNA RNA associated with metastasis-11 (RAMS11) promotes the growth and metastasis of PCa cells by binding CBX4 and activating the expression of topoisomerase IIα (TOP2α) (162). miR-129-5p (163) and miR-515-5p (164) in BC, miR-507 in GC (165), miR-6838-5p in HCC (166) and miR-497-5p in CCA (167) target CBX4 to regulate the biological characteristics of human cancers. BMP2 increases miR-181b levels to directly target and inhibit CBX4 expression in adamantinomatous craniopharyngioma (ACP), resulting in reduced regulation of CBX4-dependent HDAC3 nuclear translocation, RUNX2 activation/osteoblast differentiation and calcium deposition in ACP (168).…”

Section: Cbxs Regulate Biological Tumor Processes Through Epigenetic ...mentioning

confidence: 99%

Chromobox proteins in cancer: Multifaceted functions and strategies for modulation (Review)

et al. 2023

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Chromobox (CBX) proteins are important epigenetic regulatory proteins and are widely involved in biological processes, such as embryonic development, the maintenance of stem cell characteristics and the regulation of cell proliferation and apoptosis. Disorder and dysfunction of CBXs in cancer usually lead to the blockade or ectoptic activation of developmental pathways, promoting the occurrence, development and progression of cancer. In the present review, the characteristics and functions of CBXs were first introduced. Subsequently, the expression of CBXs in cancers and the relationship between CBXs and clinical characteristics (mainly cancer grade, stage, metastasis and relapse) and prognosis were discussed. Finally, it was described how CBXs regulate cell proliferation and self-renewal, apoptosis and the acquisition of malignant phenotypes, such as invasion, migration and chemoresistance, through mechanisms involving epigenetic modification, nuclear translocation, noncoding RNA interactions, transcriptional regulation, posttranslational modifications, protein-protein interactions, signal transduction and metabolic reprogramming. The study also focused on cancer therapies targeting CBXs. The present review provides new insight and a comprehensive basis for follow-up research on CBXs and cancer. Contents1. Introduction 2. Constituent members of CBXs 3. Characteristics and functions of PcG family CBXs 4. Characteristics and functions of HP1 family CBXs 5. Expression of CBXs in cancers and the relationship between CBXs and clinical characteristics and prognosis 6. CBXs regulate biological tumor processes through epigenetic modification, nuclear translocation, ncRNA interactions, transcriptional regulation, PTMs, proteinprotein interactions, signal transduction and metabolic reprogramming 7. Cancer therapies targeting CBXs 8. Conclusion and prospects

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“…Si et al [ 61 ] found that miR-219 regulates the expansion of LCSCs through the E-cadherin pathway. Dou et al [ 62 ] showed that miR-6838-5p inhibited self-renewal and metastasis of LCSCs by down-regulating CBX4 expression and inhibiting ERK signaling. In addition, miR-589-5p inhibited MAP3K8 in HCC and inhibited CD90 CSCs[ 63 ].…”

Section: Roles Of Cscs In Lcmentioning

confidence: 99%

Roles of cancer stem cells in gastrointestinal cancers

Xuan¹,

Hua²,

Xiang³

et al. 2023

World J Stem Cells

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Cancer stem cells (CSCs) are the main cause of tumor growth, invasion, metastasis and recurrence. Recently, CSCs have been extensively studied to identify CSC-specific surface markers as well as signaling pathways that play key roles in CSCs self-renewal. The involvement of CSCs in the pathogenesis of gastrointestinal (GI) cancers also highlights these cells as a priority target for therapy. The diagnosis, prognosis and treatment of GI cancer have always been a focus of attention. Therefore, the potential application of CSCs in GI cancers is receiving increasing attention. This review summarizes the role of CSCs in GI cancers, focusing on esophageal cancer, gastric cancer, liver cancer, colorectal cancer, and pancreatic cancer. In addition, we propose CSCs as potential targets and therapeutic strategies for the effective treatment of GI cancers, which may provide better guidance for clinical treatment of GI cancers.

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MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK signaling

Cited by 6 publications

References 32 publications

LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4

LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4

Chromobox proteins in cancer: Multifaceted functions and strategies for modulation (Review)

Roles of cancer stem cells in gastrointestinal cancers

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