MicroRNA-7a2 suppression causes hypogonadotropism and uncovers signaling pathways in gonadotropes

Crowley, William F.; Balasubramanian, R.

doi:10.1172/jci92846

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…MiR132/212 regulates Fshb mRNA expression and secretion via SIRT1 deacetylation in gonadotropes ( 71 ). MiR-7a2 or miR-200b and miR-429 participate in maintenance of gonadotropin gene expression ( 72 , 73 ). Further, miR125b contributes to desensitization of sustained GnRH stimulation by targeting components of the G αq/11 pathway ( 74 ).…”

Section: Resolution Of Gnrh-stimulated Mapk Signalingmentioning

confidence: 99%

Reactive Oxygen Species Link Gonadotropin-Releasing Hormone Receptor Signaling Cascades in the Gonadotrope

Terasaka

Adakama

et al. 2017

Front. Endocrinol.

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Biological rhythms lie at the center of regulatory schemes that control many aspects of living systems. At the cellular level, meaningful responses to external stimuli depend on propagation and quenching of a signal to maintain vigilance for subsequent stimulation or changes that serve to shape and modulate the response. The hypothalamus–pituitary–gonad endocrine axis that controls reproductive development and function relies on control through rhythmic stimulation. Central to this axis is the pulsatile stimulation of the gonadotropes by hypothalamic neurons through episodic release of the neuropeptide gonadotropin-releasing hormone. Alterations in pulsatile stimulation of the gonadotropes result in differential synthesis and secretion of the gonadotropins LH and FSH and changes in the expression of their respective hormone subunit genes. The requirement to amplify signals arising from activation of the gonadotropin-releasing hormone (GnRH) receptor and to rapidly quench the resultant signal to preserve an adaptive response suggests the need for rapid activation and feedback control operating at the level of intracellular signaling. Emerging data suggest that reactive oxygen species (ROS) can fulfill this role in the GnRH receptor signaling through activation of MAP kinase signaling cascades, control of negative feedback, and participation in the secretory process. Results obtained in gonadotrope cell lines or other cell models indicate that ROS can participate in each of these regulatory cascades. We discuss the potential advantage of reactive oxygen signaling for modulating the gonadotrope response to GnRH stimulation and the potential mechanisms for this action. These observations suggest further targets of study for regulation in the gonadotrope.

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Section: Resolution Of Gnrh-stimulated Mapk Signalingmentioning

confidence: 99%

Reactive Oxygen Species Link Gonadotropin-Releasing Hormone Receptor Signaling Cascades in the Gonadotrope

Terasaka

Adakama

et al. 2017

Front. Endocrinol.

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“…87 Altogether, these findings give rise to the intriguing possibility that prostaglandin signalling, which itself results from a dialogue between astrocytes and GnRH neurons, and miRNAs together play a role in the pathophysiology of certain cases of idiopathic hypogonadotropic hypogonadism in humans. 88 Interestingly, the activation of erbB receptors, which naturally occurs in the hypothalamus around the time of puberty, 12 has also been shown to induce changes in the morphology of hypothalamic astrocytes in vitro, 30 suggesting that erbB signalling may also play a role in the glial coverage of GnRH neurons in vivo (see reference [32]).…”

Section: Astrocyte-to-gnrh Neuron Signalling Pathwaysmentioning

confidence: 99%

“…Interestingly, the miRNAs that are upregulated in GnRH neurons at mini‐puberty include miR‐7a, 8 which has recently been shown to modulate the prostaglandin signalling pathway, 87 and whose genetic invalidation results in hypogonadotropic hypogonadism 87 . Altogether, these findings give rise to the intriguing possibility that prostaglandin signalling, which itself results from a dialogue between astrocytes and GnRH neurons, and miRNAs together play a role in the pathophysiology of certain cases of idiopathic hypogonadotropic hypogonadism in humans 88 …”

Section: Glia In the Gnrh Neuroendocrine Systemmentioning

confidence: 99%

The polygamous GnRH neuron: Astrocytic and tanycytic communication with a neuroendocrine neuronal population

Prévot

Sharif

2022

J Neuroendocrinology

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In 1973, only two years after the publication of the peptide structure of GnRH, 1,2 a neuroendocrinologist from Lille, Julien Barry, provided the first neuroanatomical description of GnRH neurons in the mammalian brain thanks to the development of immunofluorescent techniques to detect GnRH in tissue sections. 3,4 Indeed, the cell bodies of neuroendocrine GnRH neurons are diffusely distributed in the forebrain and are particularly enriched in the preoptic region in rodents, whereas in primates, including humans, they are also present in the tuberal region of the hypothalamus. 5 Unlike other hypothalamic neurons driving bodily functions, GnRH neurons are not born in

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“…представляет собой особенно важную задачу. Идентификация miR-200/429 и miR-155 в качестве ключевых игроков в управлении экспрессии ГнРГ в начале полового созревания, а также открытие важности miR-7a, экспрессия которого также увеличивается в нейронах ГнРГ во время половой зрелости в зависимости от функции гонадотропной оси, имеет значение для здоровья человека [21,26,39]. С этой точки зрения необходимы новые исследования, чтобы утвердить эти miRNAs как диагностические и терапевтические мишени для тяжелого врожденного или функционального дефицита ГнРГ в гипоталамусе.…”

Section: заключениеunclassified

Micro RNAS as New Players in Control of Hypothalamic Functions

Beylerli

Gareev

Beilerli

2019

Kreativnaâ hirurgiâ i onkologiâ

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Micro RNAs (miRNAs) are short non-coding RNAs (ncRNAs) of ~22 nucleotides in length involved in the post-transcriptional regulation of gene expression. They were discovered over 15 years ago and their functions are becoming clearer. They play an important role in all biological processes. MiRNAs are important modulators of the expression of eukaryotic genes. Focusing on transcripts encoding proteins they impact on the cellular transcriptome thus helping to determine the destiny of a cell. More and more data emerge to indicate an important functional role of miRNAs in the brain development. Since their discovery many miRNAs have been described as key factors in the development and function of the central nervous system. Some play a significant role in the genesis and differentiation of nerve cells (neurons and glial cells). Notably, it has recently been established that miRNAs play a vital role in the mechanisms underpinning the infantile increase of the gonadotropin-releasing hormone (GnRH) production by neurons in the hypothalamus. This phenomenon is necessary for the onset of puberty in mammals. In this review offers our attempt to describe miRNAs as new players in the control of hypothalamic functions, namely the onset of puberty.

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MicroRNA-7a2 suppression causes hypogonadotropism and uncovers signaling pathways in gonadotropes

Cited by 8 publications

References 9 publications

Reactive Oxygen Species Link Gonadotropin-Releasing Hormone Receptor Signaling Cascades in the Gonadotrope

Reactive Oxygen Species Link Gonadotropin-Releasing Hormone Receptor Signaling Cascades in the Gonadotrope

The polygamous GnRH neuron: Astrocytic and tanycytic communication with a neuroendocrine neuronal population

Micro RNAS as New Players in Control of Hypothalamic Functions

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