MicroRNA-802 promotes the progression of osteosarcoma through targeting p27 and activating PI3K/AKT pathway

Gao, Lifeng; Jia, Shuaijun; Zhang, Q M; Xia, Yifang; Li, C J; Li, Y H

doi:10.1007/s12094-021-02683-w

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…Skp2 was a target for cancer treatment and was implicated in controlling CDKN1B expression [ 38 ]. Furthermore, several studies have demonstrated that osteosarcomas’ overexpression of miR-802 impedes the PI3K/AKT pathway by targeting CDKN1B [ 39 ]. These findings might provide a potential role for human cancers in future research directions.…”

Section: Discussionmentioning

confidence: 99%

A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers

et al. 2023

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Background Human health and life are threatened by cancer with high morbidity and mortality worldwide. In many experiments, CDKN1B level is associated with cancer risk, Nevertheless, no pan-cancer analysis has been conducted on CDKN1B in human cancers. Methods With the help of bioinformatics, a pan-cancer analysis was conducted on the expression levels of CDKN1B in cancer tissues and adjacent tissues from the TCGA, CPTAC and GEO databases. The CDKN1B expression levels in tumor patients was further validated using immunohistochemistry (IHC) and quantitative real-time PCR. Results In the study, we first investigated the cancer-related roles of CDKN1B’s in 40 tumors with malignancy. The CDKN1B gene encodes the p27Kip1 protein, which can block the production cyclin-dependent kinase (CDK), which is obviously related to the function and survival of cancer cells and alters the prognosis of cancer patients. Furthermore, CDKN1B function requires both protein processing and RNA metabolism. Additionally, the elevated expression of the CDKN1B gene and protein was validated in several cancer tissues from the patients. Conclusions These results showed that the levels of CDKN1B were considerably different in a number of cancer tissues, offering a potential future target for cancer therapy.

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Section: Discussionmentioning

confidence: 99%

A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers

et al. 2023

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“…As a downstream molecule of PI3K/AKT pathway, P27 is regulated by PI3K/AKT pathway, and the abnormal change of p27 significantly affects cell proliferation and cell cycle, making it a target to be considered in cancer therapy (246,247). Several studies have that microRNAs can affect the function of PI3K/ AKT pathway by influencing P27 and thus, for example, miR-199a-5p (Figure 7A) (221), miR-802 (225) and miR-25 (234) can act on P27 to affect its expression by the mechanism of miR-199a-5p, miR-802 and miR-25 can directly P27 the 3-UTR binding of mRNA and mediate a decrease in P27 protein levels, thus stimulating OS cell cycle progression. MiR-106b-5p was found by Chuan He et al to cause a significant increase in the percentage of G0/G1 phase cells and a decrease in S and G2/M phase cells The number decreased, suggesting that miR-106b-5p blocks cell cycle progression by blocking osteosarcoma cells in G0/G1 phase.…”

Section: Oncogenic Factors Acting On Pi3k/akt Pathwaymentioning

confidence: 99%

Functional role of MicroRNA/PI3K/AKT axis in osteosarcoma

Yang

Liu

et al. 2023

Front. Oncol.

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Osteosarcoma (OS) is a primary malignant bone tumor that occurs in children and adolescents, and the PI3K/AKT pathway is overactivated in most OS patients. MicroRNAs (miRNAs) are highly conserved endogenous non-protein-coding RNAs that can regulate gene expression by repressing mRNA translation or degrading mRNA. MiRNAs are enriched in the PI3K/AKT pathway, and aberrant PI3K/AKT pathway activation is involved in the development of osteosarcoma. There is increasing evidence that miRNAs can regulate the biological functions of cells by regulating the PI3K/AKT pathway. MiRNA/PI3K/AKT axis can regulate the expression of osteosarcoma-related genes and then regulate cancer progression. MiRNA expression associated with PI3K/AKT pathway is also clearly associated with many clinical features. In addition, PI3K/AKT pathway-associated miRNAs are potential biomarkers for osteosarcoma diagnosis, treatment and prognostic assessment. This article reviews recent research advances on the role and clinical application of PI3K/AKT pathway and miRNA/PI3K/AKT axis in the development of osteosarcoma.

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Interaction of ncRNAs and the PI3K/AKT/mTOR pathway: Implications for osteosarcoma

Shao,

Feng,

Huang

et al. 2024

Open Life Sciences

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Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, and is characterized by high heterogeneity, high malignancy, easy metastasis, and poor prognosis. Recurrence, metastasis, and multidrug resistance are the main problems that limit the therapeutic effect and prognosis of OS. PI3K/AKT/mTOR signaling pathway is often abnormally activated in OS tissues and cells, which promotes the rapid development, metastasis, and drug sensitivity of OS. Emerging evidence has revealed new insights into tumorigenesis through the interaction between the PI3K/AKT/mTOR pathway and non-coding RNAs (ncRNAs). Therefore, we reviewed the interactions between the PI3K/AKT/mTOR pathway and ncRNAs and their implication in OS. These interactions have the potential to serve as cancer biomarkers and therapeutic targets in clinical applications.

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MicroRNA-802 promotes the progression of osteosarcoma through targeting p27 and activating PI3K/AKT pathway

Cited by 4 publications

References 25 publications

A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers

A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers

Functional role of MicroRNA/PI3K/AKT axis in osteosarcoma

Interaction of ncRNAs and the PI3K/AKT/mTOR pathway: Implications for osteosarcoma

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