microRNA-874 suppresses tumor proliferation and metastasis in hepatocellular carcinoma by targeting the DOR/EGFR/ERK pathway

Zhang, Yi; Wei, Yangchao; Li, Xuan; Liang, Xingsi; Wang, Liming; Song, Jun; Zhang, Xiuzhong; Zhang, Chong; Niu, Junfeng; Zhang, Pengbo; Ren, Zeqiang; Tang, Bo

doi:10.1038/s41419-017-0131-3

Cited by 53 publications

(42 citation statements)

References 24 publications

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“…In this research, we analysed miR-874 expression in both RB tissues and cell lines. The data of RT-qPCR analysis indicated that miR-874 (23,24). miR-874 expression is also downregulated in osteosarcoma tissues and cell lines (25,26).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑874 prohibits the proliferation and invasion of retinoblastoma cells by directly targeting metadherin

2018

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MicroRNAs (miRNAs/miRs) serve important roles in regulating gene expression by directly binding to the 3'‑untranslated regions of target genes. Multiple miRNAs are dysregulated in retinoblastoma (RB) and their dysregulation is closely related to RB malignancy. Therefore, exploring the detailed roles of miRNAs in RB is valuable to facilitate the development of effective therapeutic targets for patients with this disease. miRNA‑874‑3p (miR‑874) has been recently reported to be downregulated in several types of human cancer and serves an essential role in cancer progression. However, the expression pattern and detailed roles of miR‑874 in RB, as well as the underlying molecular mechanisms in RB, have not been clearly elucidated. Therefore, this study detected miR‑874 expression in RB tissues and cell lines. The biological roles of miR‑874 in RB were determined and the underlying mechanisms of its actions in RB cells were also examined. This study revealed that miR‑874 expression was aberrantly underexpressed in RB tissues and cell lines. However, returning miR‑874 expression restricted the proliferative and invasive abilities of RB cells. In terms of the underlying mechanism, metadherin (MTDH) was validated as a direct target gene of miR‑874 in RB cells. MTDH inhibition could imitate the inhibitory roles of miR‑874 overexpression in RB cells. Furthermore, forced MTDH expression partially reversed the suppressive effects of miR‑874 on RB cells. In conclusion, this study revealed that miR‑874 may inhibit RB progression by directly targeting MTDH. Restoration of miR‑874 expression may be a novel strategy for preventing the rapid growth and metastasis of RB cells.

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Section: Discussionmentioning

confidence: 99%

MicroRNA‑874 prohibits the proliferation and invasion of retinoblastoma cells by directly targeting metadherin

2018

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“…17 miR-874 represses HCC progression via modulating the δ opioid receptor (DOR). 18 Currently, we reported LINC00152 was overexpressed in HCC cells whereas miR-215 was inhibited. CDK13 was speculated as the putative target of miR-215.…”

Section: Introductionmentioning

confidence: 98%

“…Additionally, miR‐138 can inhibit HCC via modulating SP1 . miR‐874 represses HCC progression via modulating the δ opioid receptor (DOR) …”

Section: Introductionmentioning

confidence: 99%

Insight into the molecular mechanism of LINC00152/miR‐215/CDK13 axis in hepatocellular carcinoma progression

Wang

Zhang

et al. 2019

J of Cellular Biochemistry

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. Nevertheless, its underlying molecular mechanisms are largely unknown. LINC00152 are recently investigated in several cancer types. In our current investigation, we observed LINC00152 was obviously upregulated in HCC cells. LINC00152 was significantly downregulated by infecting LV‐shLINC00152 in HepG2 and SNU449 cells. Loss of LINC00152 remarkably repressed HCC cell proliferation, cell colony formation, induced cell apoptosis, and restrained cell migration/invasion. Growing evidence has reported long noncoding RNAs can sponge microRNAs to modulate cancer process. Here, we indicated miR‐215 was greatly decreased in HCC and LINC00152 regulated HCC development via sponging miR‐215. For another, the binding association between LINC00152 and miR‐215 was proved by a series of functional assays. CDK13 was predicted as the target of miR‐215. Upregulation of miR‐215 greatly depressed CDK13 in HCC cells. Subsequently, the in vivo results demonstrated that silence of LINC00152 restrained HCC development via modulating miR‐215 to up‐regulate CDK13. Therefore, it was revealed that LINC00152 contributed to the progression of HCC by the modulation of miR‐215 and CDK13.

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“…miRNAs are noncoding endogenous RNA molecules with a length of 18~25 nucleotides, which are partially or completely complementary to the 3 ′ or 5 ′ untranslated region (UTR) of target genes [1,2]. miRNAs play a vital role in a wide range of biological processes including cell proliferation, differentiation, and apoptosis [3][4][5][6][7]. In addition, increasing evidences have been revealed demonstrating that the occurrences of many diseases including cancers are closely associated with abnormal expression of specific miRNAs [8], e.g., prostate cancer-associated miR-21 and miR-141 [9], breast cancer-associated miR-155-3p [10], and liver fibrosis-associated miR-378 [11].…”

Section: Introductionmentioning

confidence: 99%

DNA Dumbbell and Chameleon Silver Nanoclusters for miRNA Logic Operations

Jiang

2020

Research

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Multiplex miRNA analysis is a fundamental issue for exploring a complex biological system and early diagnosis of miRNA-related diseases. Herein, we have developed a series of novel logic gates for miRNA analysis coupling DNA nanostructures and chameleon silver nanoclusters (AgNCs). DNA dumbbell structures are firstly designed with two independent nucleation sequences for AgNCs at the 5′ and 3′ ends, respectively. By introducing different miRNA inputs, separations of two AgNCs are controlled and the fluorescence property of AgNCs changes. By studying the ratiometric fluorescence responses, sensitive and selective analysis of multiple miRNAs can be achieved. The present work provides powerful tools for miRNA diagnostics and may also guide future DNA nanostructure-based logic gates.

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microRNA-874 suppresses tumor proliferation and metastasis in hepatocellular carcinoma by targeting the DOR/EGFR/ERK pathway

Cited by 53 publications

References 24 publications

MicroRNA‑874 prohibits the proliferation and invasion of retinoblastoma cells by directly targeting metadherin

MicroRNA‑874 prohibits the proliferation and invasion of retinoblastoma cells by directly targeting metadherin

Insight into the molecular mechanism of LINC00152/miR‐215/CDK13 axis in hepatocellular carcinoma progression

DNA Dumbbell and Chameleon Silver Nanoclusters for miRNA Logic Operations

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