MicroRNA-9 and microRNA-126 expression levels in patients with essential hypertension: potential markers of target-organ damage

Kontaraki, Joanna; Marketou, Maria; Zacharis, E.; Parthenakis, Fragiskos I.; Vardas, Panos

doi:10.1016/j.jash.2014.03.324

Cited by 102 publications

(68 citation statements)

References 45 publications

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“…[18] Whilst associations for 24-hour mean blood pressure and mean DBP were not provided for miR-9 or miR-126, both correlated positively with mean pulse pressure. [19] Finally, miR-9 (but not miR-126) also correlated positively with left ventricular mass index. [19] Elsewhere, Ceolotto et al [20] correlations remained significant after correction for 24-hour systolic or diastolic blood pressure.…”

Section: Circulating Micrornas and Existing Mechanisms Of Blood Pressmentioning

confidence: 93%

“…[19] Finally, miR-9 (but not miR-126) also correlated positively with left ventricular mass index. [19] Elsewhere, Ceolotto et al [20] correlations remained significant after correction for 24-hour systolic or diastolic blood pressure. [23] Whilst further validation is clearly required, these findings suggest that microRNAs (or panels of microRNAs) herald great potential to identify target-organ damage in hypertension, independent of blood pressure.…”

Section: Circulating Micrornas and Existing Mechanisms Of Blood Pressmentioning

confidence: 93%

“…[18,19] Amongst hypertensive individuals, miR-21, miR-143, and miR-145 negatively correlated with 24-hour ambulatory mean blood pressure, mean DBP and mean pulse pressure; miR-133 positively correlated with each of these measures. [18] Whilst associations for 24-hour mean blood pressure and mean DBP were not provided for miR-9 or miR-126, both correlated positively with mean pulse pressure.…”

Section: Circulating Micrornas and Existing Mechanisms Of Blood Pressmentioning

confidence: 99%

“…This analysis implicated miR-181a in pathways associated with mitochondrial respiratory function, immunity and inflammation. [16] In a similar approach, the Vardas laboratory focussed on microRNAs linked to vascular smooth muscle modulation, [18] hypertrophy and endothelial dysfunction [19] in animal and tissue models.…”

Section: Circulating Micrornas and Existing Mechanisms Of Blood Pressmentioning

confidence: 99%

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Circulating microRNAs and hypertension—from new insights into blood pressure regulation to biomarkers of cardiovascular risk

Romaine

Charchar

Samani

et al. 2016

Current Opinion in Pharmacology

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Section: Circulating Micrornas and Existing Mechanisms Of Blood Pressmentioning

confidence: 93%

Section: Circulating Micrornas and Existing Mechanisms Of Blood Pressmentioning

confidence: 93%

Section: Circulating Micrornas and Existing Mechanisms Of Blood Pressmentioning

confidence: 99%

Section: Circulating Micrornas and Existing Mechanisms Of Blood Pressmentioning

confidence: 99%

See 2 more Smart Citations

Circulating microRNAs and hypertension—from new insights into blood pressure regulation to biomarkers of cardiovascular risk

Romaine

Charchar

Samani

et al. 2016

Current Opinion in Pharmacology

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“…MicroRNAs are an abundant class of small (ϳ22 nt) endogenous noncoding RNAs that direct posttranscriptional regulation of gene expression. There is ample evidence that dysregulation of microRNAs is associated with the pathogenesis of human diseases, including cardiovascular diseases as markers and therapeutic targets (26) specifically in hypertensive patients (26,29), and shows great promise in application to understanding SHR hypertension (5, 44, 57). Disease-associated microRNAs represent a new class of targets for the development of microRNA-based therapeutic modalities, which may yield patient benefits unobtainable by other therapeutic approaches (7,16,36).…”

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confidence: 99%

MicroRNA network changes in the brain stem underlie the development of hypertension

DeCicco

Zhu

Brureau

et al. 2015

Physiological Genomics

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sion is a major chronic disease whose molecular mechanisms remain poorly understood. We compared neuroanatomical patterns of microRNAs in the brain stem of the spontaneous hypertensive rat (SHR) to the Wistar Kyoto rat (WKY, control). We quantified 419 wellannotated microRNAs in the nucleus of the solitary tract (NTS) and rostral ventrolateral medulla (RVLM), from SHR and WKY rats, during three main stages of hypertension development. Changes in microRNA expression were stage-and region-dependent, with a majority of SHR vs. WKY differential expression occurring at the hypertension onset stage in NTS versus at the prehypertension stage in RVLM. Our analysis identified 24 microRNAs showing time-dependent differential expression in SHR compared with WKY in at least one brain region. We predicted potential gene regulatory targets corresponding to catecholaminergic processes, neuroinflammation, and neuromodulation using the miRWALK and RNA22 databases, and we tested those bioinformatics predictions using high-throughput quantitative PCR to evaluate correlations of differential expression between the microRNAs and their predicted gene targets. We found a novel regulatory network motif consisting of microRNAs likely downregulating a negative regulator of prohypertensive processes such as angiotensin II signaling and leukotriene-based inflammation. Our results provide new evidence on the dynamics of microRNA expression in the development of hypertension and predictions of microRNA-mediated regulatory networks playing a region-dependent role in potentially altering brain-stem cardiovascular control circuit function leading to the development of hypertension.hypertension; microRNA; neuroinflammation; angiotensin II; brain stem HYPERTENSION IS A MAJOR CHRONIC disease worldwide, affecting about 50 million adults in the United States alone. It is a multiorgan disease and a major cause of heart failure, coronary heart disease, atrial fibrillation, stroke, and end-stage renal disease, and it has an enormous economic impact. About 90 -95% of cases are "essential" with no known medical cause (11). Moreover, only about a third of hypertensive patients have their blood pressure fully controlled (11). A significant and increasing population (ϳ25%) of hypertensive patients is drug resistant. There remains an unmet need for antihypertensive therapy.In the context of the recent discovery of novel lines of therapeutic interventions involving approaches to modulate microRNA we decided to elucidate changes in microRNA levels during the development of spontaneous hypertensive rat (SHR) hypertension. The recent explosion in microRNA research has produced new computational and experimental approaches for studying microRNA functions in cell culture and in vivo, which we take advantage of here. MicroRNAs are an abundant class of small (ϳ22 nt) endogenous noncoding RNAs that direct posttranscriptional regulation of gene expression. There is ample evidence that dysregulation of microRNAs is associated with the pathogenesis of human diseases, in...

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Expression levels of circulating microRNAs‐126, ‐155, and ‐145 in Mexican women exposed to polycyclic aromatic hydrocarbons through biomass fuel use

Ruíz-Vera

Ochoa-Martínez

Pruneda-Álvarez

et al. 2019

Environ and Mol Mutagen

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Human exposure to polycyclic aromatic hydrocarbons (PAHs) has been considered a risk determinant for the development of cardiovascular diseases (CVD). Therefore, the aim of this study was to assess expression levels of vascular‐related miRNAs, miR‐126, miR‐155, and miR‐145, in plasma from women (aged 19–81 years) exposed (n = 100) and non‐exposed (n = 20) to PAHs via biomass combustion smoke.1‐hydroxypyrene (1‐OHP) was determined in urine as a biomarker of exposure to PAHs using high‐resolution liquid chromatography. Plasma expression levels of proposed miRNAs were determined by quantitative real‐time PCR. Additionally, traditional risk factors (age, blood pressure, serum lipid profile, blood glucose, and among others) associated with CVD were evaluated. Urinary 1‐OHP concentrations and plasma expression levels of miR‐126 and miR‐155 were significantly higher (P < 0.05) in women using wood as a fuel source in their homes (indoor) compared to women from the reference group (non‐exposed to biomass smoke). Besides, multivariate linear regression analyses revealed that miR‐126[β = 0.61; 95% confidence interval (0.32–0.90)] and miR‐155 [β = 0.45; 95% confidence interval (0.13–0.84)] expression levels were significantly associated with urinary 1‐OHP concentrations after being adjusted by traditional risk factors (P < 0.05). In contrast, no significant relationship was found between miR‐145 and urinary 1‐OHP levels. Furthermore, miRNAs assessed in this investigation are associated with CVD events. Consequently, actions to reduce exposure to PAHs in the evaluated population are warranted. Environ. Mol. Mutagen. 60:546–558, 2019. © 2019 Wiley Periodicals, Inc.

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MicroRNA-9 and microRNA-126 expression levels in patients with essential hypertension: potential markers of target-organ damage

Cited by 102 publications

References 45 publications

Circulating microRNAs and hypertension—from new insights into blood pressure regulation to biomarkers of cardiovascular risk

Circulating microRNAs and hypertension—from new insights into blood pressure regulation to biomarkers of cardiovascular risk

MicroRNA network changes in the brain stem underlie the development of hypertension

Expression levels of circulating microRNAs‐126, ‐155, and ‐145 in Mexican women exposed to polycyclic aromatic hydrocarbons through biomass fuel use

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