MicroRNA-9 facilitates hypoxia-induced injury and apoptosis in H9c2 cells via targeting CDK8

Dou, Pengcheng; Tan, Guangshuang; Zhai, Fan; Xiao, Jiatong; Shi, Chaoran; Lin, Zhengjun

doi:10.1007/s12038-020-00126-2

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…Wu et al demonstrated that miR-613 attenuates cell apoptosis by targeting Programmed cell death 10 (PDCD10) in cardiomyocytes undergoing ischemia/reperfusion [62]. Hypoxia treatment also augments miR-9 expression levels, and miR-9 enhances cell apoptosis via repressing CDK8; in fact, knockdown of CDK8 reverses the inhibitory effects of miR-9 downregulation and increases cell apoptosis [63].…”

Section: 整体完成率没有问题，但是做稿子速度慢了一点，有时候周末要加班。正如范丽影自己说的，自己是个问题宝宝，爱问问题的宝...mentioning

confidence: 99%

Functional Role of microRNAs in Regulating Cardiomyocyte Death

Kansakar

Varzideh

Mone

et al. 2022

Cells

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microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numerous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.

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Section: 整体完成率没有问题，但是做稿子速度慢了一点，有时候周末要加班。正如范丽影自己说的，自己是个问题宝宝，爱问问题的宝...mentioning

confidence: 99%

Functional Role of microRNAs in Regulating Cardiomyocyte Death

Kansakar

Varzideh

Mone

et al. 2022

Cells

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“…Сверхэкспрес-сия CDK8 выявлена также при раке молочной железы и раке яичников [39], при колоректальном раке [34]. Недавние исследования показали, что транскрипция CDK8 может быть подавлена специфичными микроРНК (miR-9), что в свою очередь подавляет пролиферацию клеток и усиливает их апоптоз [27]. Роль CDK19 в патогенезе онкологических заболеваниях изучена хуже.…”

Section: транскрипционная регуляция клеток иммунной системы с участие...unclassified

Decidual natural killer cells and trophoblast cells: cellular, humoral and molecular mechanisms of interaction

et al. 2022

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Natural killer cells (NK cells) represent a group of lymphocytes of innate immunity. In addition to NK cells of peripheral blood, tissue-resident populations are described. NK cells of the decidual envelope (decidual NK cells) represent one of the local NK cell populations. Decidual NK cells differ in phenotype and function from peripheral blood NK cells. These cells have, mainly, regulatory functions. At the same time they retain the ability to perform cytotoxic effects. In the uterus, NK cells are located closely to the cells of fetal origin, i.e., trophoblast cells, which differentiate from the outer layer of the invading blastocyst. The purpose of the review article was to analyze the literature data on the studies of the molecular interactions between NK cells and trophoblast cells, as well as potential means of regulating these interactions. The review presents currently available data on receptor-mediated effects (due to adhesion molecules and cytotoxic receptors) and distant interactions (involving cytokines, chemokines and growth factors secreted by the both cell types) between NK population and trophoblast cells. The receptors regulating contacts of NK cells and trophoblast cells with extracellular matrix are also considered. The review provides information on activation of signaling pathways in NK cells and trophoblast cells resulting from their interaction with each other and components of the extracellular matrix. Currently, the molecular mechanisms regulating the NK cell functions and their interaction with trophoblast cells have not been studied sufficiently. The authors attempted to consider molecular regulation of the functional activity of NK cells mediated by the molecular complex of RNA polymerase II. We also describe participation of cyclin-dependent CDK8/19 kinases which comprise a part of the mediator complex which provides functioning of immune cells. The data on the participation of CDK8/19 in regulation of intracellular signaling pathways, as well as influence of CDK8/19 on the NK cell functions, are considered. Summarizing the data presented in the literature, one may emphasize that there is an extensive mutual influence of NK cells and trophoblast cells in decidual lining of uterus during pregnancy, thus leading to a changes in phenotype and functions of these cells. Experimental studies are required on the contribution of molecular mechanisms involved in transcription and translation processes to the biology of NK cells, and their role in maintaining interactions between NK cells and trophoblast cells, including the pathways involving CDK8/19.

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