MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases

Dai, Rujuan; Ahmed, S. Ansar

doi:10.1016/j.trsl.2011.01.007

Cited by 394 publications

(332 citation statements)

References 181 publications

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“…In some inflammatory disorders, studies have suggested that prominent up-regulation of miRNAs, such as miR21, is specifically involved in modulating TLR associated NFκB signaling networks activated by the pathological microenvironment (Kalla et al, 2015). Conceivably, miR146a is differentially expressed in various autoimmune diseases including rheumatoid arthritis and multiple sclerosis and its regulation may influence the development or prevention of autoimmunity (Dai and Ahmed, 2011). As exosomes naturally transfer RNA molecules between cells, this property may be useful in gene therapy, in which a vector is used to deliver therapeutic nucleic acids to the patient's target cells.…”

Section: Perspectives and Final Remarksmentioning

confidence: 99%

Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation

Hao

et al. 2016

Sci. China Life Sci.

127

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Clinical and experimental studies have highlighted the significance of inflammation in coordinating wound repair and regeneration. However, it remains challenging to control the inflammatory response and tolerance at systemic levels without causing toxicity to injured tissues. Mesenchymal stem cells (MSCs) possess potent immunomodulatory properties and facilitate tissue repair by releasing exosomes, which generate a suitable microenvironment for inflammatory resolution. Exosomes contain several effective bioactive molecules and act as a cell-cell communication vehicle to influence cellular activities in recipient cells. During this process, the horizontal transfer of exosomal microRNAs (miRNAs) to acceptor cells, where they regulate target gene expression, is of particular interest for understanding the basic biology of inflammation ablation, tissue homeostasis, and development of therapeutic approaches. In this review, we describe a signature of three specific miRNAs (miR-21, miR-146a, and miR-181) present in human umbilical cord MSC-derived exosomes (MSC-EXO) identified microarray chip analysis and focus on the inflammatory regulatory functions of these immune-related miRNAs. We also discuss the potential mechanisms contributing to the resolution of wound inflammation and tissue healing.

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Section: Perspectives and Final Remarksmentioning

confidence: 99%

Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation

Hao

et al. 2016

Sci. China Life Sci.

127

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“…Therefore, not surprisingly, abnormalities in the expression and functioning of miRNAs have been identified as part of the pathogenesis of autoimmune diseases including SLE [Dai and Ahmed, 2011;Shen et al 2012] . Dai and colleagues first reported the identification of six miRNAs whose expression was altered in the peripheral blood mononuclear cells (PBMCs) prepared from patients with SLE, but not patients with idiopathic thrombocytopenic purpura [Dai et al 2007].…”

Section: Epigenetics-related Biomarkersmentioning

confidence: 99%

Biomarkers in systemic lupus erythematosus: challenges and prospects for the future

Liu

Kao

Manzi

et al. 2013

Therapeutic Advances in Musculoskeletal

106

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Abstract:The search for lupus biomarkers to diagnose, monitor, stratify, and predict individual response to therapy is currently more intense than ever before. This effort is essential for several reasons. First, epidemic overdiagnosis and underdiagnosis of lupus, even by certified rheumatologists, leads to errors in therapy with concomitant side effects which may be more serious than the disease itself. Second, identification of lupus flares remains as much an art as it is a science. Third, the capacity to stratify patients so as to predict those who will develop specific patterns of organ involvement is not currently possible but would potentially lead to preventive therapeutic strategies. Fourth, only one new drug for the treatment of lupus has been approved by the US Food and Drug Administration in over 50 years. A major obstacle in this pipeline is the dearth of biomarkers available to prove a patient has responded to an experimental therapeutic intervention. This review will summarize the challenges faced in the discovery and validation of lupus biomarkers, the most promising lupus biomarkers identified to date, and the promise of future directions.

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“…miRNA is estimated to control 30-90% of human genes (4). miRNA has been suggested to either suppress messenger RNA (mRNA) translation or reduce mRNA stability by binding particular regions of mRNA (5).…”

Section: Introductionmentioning

confidence: 99%

Volatile anesthetic sevoflurane ameliorates endotoxin-induced acute lung injury via microRNA modulation in rats

et al. 2015

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Abstract. Volatile anesthetics have a lung protective effect in acute lung injury (ALI). Our previous study showed sevoflurane affects the expression of microRNA (miRNA) that control various physiological systems by regulating messenger RNA (mRNA) expression. However, the association between the anti-inflammatory effect of sevoflurane and miRNAs modulation remains unknown. The aim of the present study was to investigate the effect of sevoflurane and the expression of miRNAs in an endotoxin-induced ALI model in rats. Wistar rats were randomly assigned to three groups [lipopolysaccharide (LPS), LPS-sevoflurane and control; n=8/group]. All the rats were mechanically ventilated and intravenously-administered LPS (saline as control). Two hours post-injury, general anaesthesia was performed for 4 h with 2% sevoflurane (LPS-sevoflurane). The LPS and the control groups did not receive anaesthesia. The severity of ALI was evaluated by partial pressure of oxygen/fraction of inspired oxygen and the mRNA expression of inflammatory cytokine. The miRNA expression in lung tissue was analyzed by a reverse transcription-quantitative polymerase chain reaction. LPS caused ALI, evidenced by the impairment of pulmonary function and increased mRNA levels of tumor necrosis factor-α, interleukin-6 and nuclear factor-κB. Sevoflurane improved pulmonary function and inhibited the increased mRNAs. Of the 219 miRNAs detected, 15 and nine miRNAs were significantly changed in the LPS and LPS-sevoflurane group, respectively. In the LPS-sevoflurane group, the expression of several miRNAs that regulate inflammation was significantly changed compared to the LPS group. In conclusion, the present data showed that sevoflurane influences the expression of the miRNAs that regulate inflammation. This result suggests that the changes in miRNA expression are involved in the lung protective mechanisms of volatile anesthetics. IntroductionAcute lung injury (ALI) is a major complication in critically ill patients (1). Therefore, it is important to preserve lung function and prevent further exacerbation for those patients whose lungs are already vulnerable prior to surgery. The volatile anesthetic sevoflurane is known to have organ protective effects in several pathological conditions. For example, Voigtsberger et al (2) have recently shown that sevoflurane ameliorates gas exchange and attenuates lung damage in a model of lipopolysaccharide (LPS)-induced ALI.MicroRNA (miRNA) is a newly discovered and non-coding RNA that regulates genome expression at the post-transcriptional level (3). miRNA is estimated to control 30-90% of human genes (4). miRNA has been suggested to either suppress messenger RNA (mRNA) translation or reduce mRNA stability by binding particular regions of mRNA (5). Recent published data have also revealed that the expression and function of miRNA are associated with a broad range of diseases.In our previous study, it was found that sevoflurane affects the expression of miRNAs in normal rat lung (6). However, such effects of anesthetic ALI ...

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MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases

Cited by 394 publications

References 181 publications

Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation

Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation

Biomarkers in systemic lupus erythematosus: challenges and prospects for the future

Volatile anesthetic sevoflurane ameliorates endotoxin-induced acute lung injury via microRNA modulation in rats

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