2019
DOI: 10.1002/jcb.28499
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MicroRNA and exosome: Key players in rheumatoid arthritis

Abstract: Rheumatoid arthritis (RA) is known as one of important autoimmune disorders which can lead to joint pain and damage throughout body. Given that internal (ie, genetic and epigenetic alterations) and external factors (ie, lifestyle changes, age, hormones, smoking, stress, and obesity) involved in RA pathogenesis.

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Cited by 36 publications
(30 citation statements)
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“…Fortunately, extraction of exosomes from serum and using the mixed approach (i.e. the combination of high-throughput experimental procedures coupled with computational methods) to decipher and validate new miRNAs are quite promising [40,41].…”
Section: Micrornas In Rheumatoid Arthritis: What Is the Latest With Rmentioning
confidence: 99%
“…Fortunately, extraction of exosomes from serum and using the mixed approach (i.e. the combination of high-throughput experimental procedures coupled with computational methods) to decipher and validate new miRNAs are quite promising [40,41].…”
Section: Micrornas In Rheumatoid Arthritis: What Is the Latest With Rmentioning
confidence: 99%
“…MicroRNAs (miRNAs) fine-tune the gene expression by enhancing the mRNA degradation or translational repression at the post-transcriptional level [10,11]. Recent evidence has reported the aberrant expression of miRNAs in RA, with involvement in T-cell mediation and promising potential as biomarkers of diagnosis, or intervention efficacy [12,13].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, urinary exosomes can be used as biomarkers for diagnosis of urinary tract infection . Moreover, Zakeri et al reported that exosomes are significant messengers in rheumatoid arthritis . The diagnostic functions of exosomes in the fields of pregnancy, infections, tumor, stem cells, heart, and brain have already been summarized in previous reviews ( Figure ) .…”
Section: Exosomesmentioning
confidence: 95%
“…[16] Moreover, Zakeri et al reported that exosomes are significant messengers in rheumatoid arthritis. [10] The diagnostic functions of exosomes in the fields of pregnancy, infections, tumor, stem cells, heart, and brain have already been summarized in previous reviews (Figure 3). [64] For example, tumor-derived exosomes play a role in the progression, survival, metastasis, and drug resistance of tumors.…”
Section: Contents and Functions Of Exosomesmentioning
confidence: 99%
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