microRNA dysregulation in neurodegenerative diseases: A systematic review

Juźwik, Camille A.; Drake, Sienna S.; Zhang, Yang; Paradis-Isler, Nicolas; Sylvester, Alexandra; Amar‐Zifkin, Alexandre; Douglas, Chelsea; Morquette, Barbara; Moore, Craig S.; Fournier, Alyson E.

doi:10.1016/j.pneurobio.2019.101664

Cited by 329 publications

(220 citation statements)

References 142 publications

(193 reference statements)

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“…miRNAs show a variety of important physiological functions in the CNS and perturbations of their expression profiles or those of their target genes have been associated with pathological processes affecting this system, including neurodegeneration [118,119]. The miR-181 family is highly expressed in different regions of the CNS and a functional role for the miR-181 family in more specific neurological processes such as neurotrophin signaling pathway, axon guidance, immunity, and mitochondrial-related pathways is also emerging [12,26,28,35,120].…”

Section: The Mir-181 Family In Neurodegenerative Diseasesmentioning

confidence: 99%

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

Indrieri

Carrella

Carotenuto

et al. 2020

IJMS

117

110

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MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the regulation of gene expression. Evidence accumulating in the past decades indicate that they are capable of simultaneously modulating diverse signaling pathways involved in a variety of pathophysiological processes. In the present review, we provide a comprehensive overview of the function of a highly conserved group of miRNAs, the miR-181 family, both in physiological as well as in pathological conditions. We summarize a large body of studies highlighting a role for this miRNA family in the regulation of key biological processes such as embryonic development, cell proliferation, apoptosis, autophagy, mitochondrial function, and immune response. Importantly, members of this family have been involved in many pathological processes underlying the most common neurodegenerative disorders as well as different solid tumors and hematological malignancies. The relevance of this miRNA family in the pathogenesis of these disorders and their possible influence on the severity of their manifestations will be discussed. A better understanding of the miR-181 family in pathological conditions may open new therapeutic avenues for devasting disorders such as neurodegenerative diseases and cancer.

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Section: The Mir-181 Family In Neurodegenerative Diseasesmentioning

confidence: 99%

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

Indrieri

Carrella

Carotenuto

et al. 2020

IJMS

117

110

View full text Add to dashboard Cite

show abstract

“…MicroRNAs are also emerging targets that have gained increased attention in neurodegenerative disorders, including PD [28]. These small RNAs play relevant roles in regulating cell transcriptome by RNA interference, but they can also contribute to disease pathogenesis if aberrantly expressed [29,30]. In such sense, a dysregulated expression of a specific microRNA can be set up to the physiological level by synthetic oligos for disrupting critical mechanisms of disease pathogenesis [31,32].…”

Section: The Underlying Mechanisms Of Parkinson's Disease (Pd)mentioning

confidence: 99%

The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson’s Disease

Titze‐de‐Almeida

Soto-Sánchez

Fernández

et al. 2020

Cells

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MicroRNAs (miRNAs) are small double-stranded RNAs that exert a fine-tuning sequence-specific regulation of cell transcriptome. While one unique miRNA regulates hundreds of mRNAs, each mRNA molecule is commonly regulated by various miRNAs that bind to complementary sequences at 3’-untranslated regions for triggering the mechanism of RNA interference. Unfortunately, dysregulated miRNAs play critical roles in many disorders, including Parkinson’s disease (PD), the second most prevalent neurodegenerative disease in the world. Treatment of this slowly, progressive, and yet incurable pathology challenges neurologists. In addition to L-DOPA that restores dopaminergic transmission and ameliorate motor signs (i.e., bradykinesia, rigidity, tremors), patients commonly receive medication for mood disorders and autonomic dysfunctions. However, the effectiveness of L-DOPA declines over time, and the L-DOPA-induced dyskinesias commonly appear and become highly disabling. The discovery of more effective therapies capable of slowing disease progression –a neuroprotective agent–remains a critical need in PD. The present review focus on miRNAs as promising drug targets for PD, examining their role in underlying mechanisms of the disease, the strategies for controlling aberrant expressions, and, finally, the current technologies for translating these small molecules from bench to clinics.

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“…Although most ncRNAs cannot be translated into protein, many function in the regulation of important biological processes by modulating transcription and post-translational modifications [reviewed in [1]]. Among the subtypes of ncRNAs, microRNAs are known to influence many aspects of metazoan biology primarily by mediating mRNA stability and preventing translation [reviewed in [2]]. NATs also interfere with stability of the corresponding sense transcript and affect protein translation and function.…”

Section: Introductionmentioning

confidence: 99%

Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases

2020

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Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific expression patterns. Moreover, ncRNAs have been found to intricately and dynamically regulate various signaling pathways in neurodegeneration. As such, some antisense transcripts and microRNAs are known to directly affect neurodegeneration in disease contexts. The functions of ncRNAs in pathogenesis are unique for each disorder, as are the pertinent networks of ncRNA/miRNA/ mRNA that mediate these functions. Thus, further understanding of ncRNA biogenesis and effects might aid the discovery of diagnostic biomarkers or development of effective therapeutics for neurodegenerative disorders. Here, we review the ncRNAs that have so far been identified in major neurodegenerative disease etiology and the mechanisms that link ncRNAs with disease-specific phenotypes, such as HTT aggregation in HD, α-synuclein in PD, and Aβ plaques and hyperphosphorylated Tau in AD. We also summarize the known lncRNA/miRNA/mRNA networks that participate in neurodegenerative diseases, and we discuss ncRNA-related treatments shown to delay disease onset and prolong lifespan in rodent models.

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microRNA dysregulation in neurodegenerative diseases: A systematic review

Cited by 329 publications

References 142 publications

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson’s Disease

Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases

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