MicroRNA Dysregulation in Parkinson’s Disease: A Narrative Review

Nies, Yong Hui; Najib, Nor Haliza Mohamad; Lim, Wei Ling; Kamaruzzaman, Mohd Amir; Yahaya, Mohamad Fairuz; Teoh, Seong Lin

doi:10.3389/fnins.2021.660379

Cited by 67 publications

(51 citation statements)

References 144 publications

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“…miR-494 bind PARK7 3 UTR reducing its expression. Very interestingly this miRNA is highly upregulated both in plasma and saliva of PD patients [75].…”

Section: Mirnas Involved In the Pathogenesis Of Pdmentioning

confidence: 99%

“…It has been shown that there are miRNAs involved in the regulation of SNCA expression and accumulation. Among them, miR-7a and miR-153 are able to post-transcriptionally regulate the expression of SNCA: miR-7a inhibits its translation, whereas miR-153 degrades its mRNA [75]. In particular, depletion of miR-7a is related with SNCA accumulation and neuron loss in vivo [76].…”

Section: Mirnas Involved In the Pathogenesis Of Pdmentioning

confidence: 99%

“…It has been demonstrated that miR-103a-3p downregulates the PRNK expression binding its 3 UTR. In addition, PRNK is a target of other miRNAs, such as miR-181a and miR-218, in particular the latter is reduced in PD patients [75]. On the other side, miR-27a/b can suppress the expression of PTEN Induced Kinase 1 (PINK1), a gene involved in the respiratory chain and ATP production.…”

Section: Mirnas Involved In the Pathogenesis Of Pdmentioning

confidence: 99%

“…On the other side, miR-27a/b can suppress the expression of PTEN Induced Kinase 1 (PINK1), a gene involved in the respiratory chain and ATP production. Its mutation is linked with the early onset of PD [75].…”

Section: Mirnas Involved In the Pathogenesis Of Pdmentioning

confidence: 99%

“…It has been reported that some miRNAs are involved in the survival of DA neurons and their deregulation can contribute to the development of PD [75]. As the loss of DA neurons is responsible for the development of PD symptoms in patients, non-coding RNAs may be consider as a target to prevent the neuronal loss [110].…”

Section: Mirnas and Lncrnas Involved In The Survival Of Da Neurons And Da Cell Linesmentioning

confidence: 99%

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Chemical and Biological Molecules Involved in Differentiation, Maturation, and Survival of Dopaminergic Neurons in Health and Parkinson’s Disease: Physiological Aspects and Clinical Implications

et al. 2021

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Parkinson’s disease (PD) is one of the most common neurodegenerative disease characterized by a specific and progressive loss of dopaminergic (DA) neurons and dopamine, causing motor dysfunctions and impaired movements. Unfortunately, available therapies can partially treat the motor symptoms, but they have no effect on non-motor features. In addition, the therapeutic effect reduces gradually, and the prolonged use of drugs leads to a significative increase in the number of adverse events. For these reasons, an alternative approach that allows the replacement or the improved survival of DA neurons is very appealing for the treatment of PD patients and recently the first human clinical trials for DA neurons replacement have been set up. Here, we review the role of chemical and biological molecules that are involved in the development, survival and differentiation of DA neurons. In particular, we review the chemical small molecules used to differentiate different type of stem cells into DA neurons with high efficiency; the role of microRNAs and long non-coding RNAs both in DA neurons development/survival as far as in the pathogenesis of PD; and, finally, we dissect the potential role of exosomes carrying biological molecules as treatment of PD.

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“…miR-494 bind PARK7 3 UTR reducing its expression. Very interestingly this miRNA is highly upregulated both in plasma and saliva of PD patients [75].…”

Section: Mirnas Involved In the Pathogenesis Of Pdmentioning

confidence: 99%

Section: Mirnas Involved In the Pathogenesis Of Pdmentioning

confidence: 99%

Section: Mirnas Involved In the Pathogenesis Of Pdmentioning

confidence: 99%

Section: Mirnas Involved In the Pathogenesis Of Pdmentioning

confidence: 99%

Section: Mirnas and Lncrnas Involved In The Survival Of Da Neurons And Da Cell Linesmentioning

confidence: 99%

See 3 more Smart Citations

Chemical and Biological Molecules Involved in Differentiation, Maturation, and Survival of Dopaminergic Neurons in Health and Parkinson’s Disease: Physiological Aspects and Clinical Implications

et al. 2021

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Glycolipids in Parkinson's disease: beyond neuronal function

Spanos

Deleidi

2023

FEBS Open Bio

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Glycolipid balance is key to normal body function, and its alteration can lead to a variety of diseases involving multiple organs and tissues. Glycolipid disturbances are also involved in Parkinson's disease (PD) pathogenesis and aging. Increasing evidence suggests that glycolipids affect cellular functions beyond the brain, including the peripheral immune system, intestinal barrier, and immunity. Hence, the interplay between aging, genetic predisposition, and environmental exposures could initiate systemic and local glycolipid changes that lead to inflammatory reactions and neuronal dysfunction. In this review, we discuss recent advances in the link between glycolipid metabolism and immune function and how these metabolic changes can exacerbate immunological contributions to neurodegenerative diseases, with a focus on PD. Further understanding of the cellular and molecular mechanisms that control glycolipid pathways and their impact on both peripheral tissues and the brain will help unravel how glycolipids shape immune and nervous system communication and the development of novel drugs to prevent PD and promote healthy aging.

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